Which of the six WHO MDS subgroups contains two or more cytopenias, rare or no blasts, less than 1 x 109 /L monocytes in the peripheral blood and less than 5% blasts and less than 15% ringed sideroblasts in the bone marrow?

A) Refractory anemia (R A) B) Refractory anemia with ringed sideroblasts (RARS) C) Refractory cytopenia with multilineage dysplasia (RCM D) D) Refractory anemia with excess blasts 2 (RAEB 2) A) Refractory anemia (R A) B) Refractory anemia with ringed sideroblasts (RARS) C) Refractory cytopenia with multilineage dysplasia (RCM D) D) Refractory anemia with excess blasts 2 (RAEB 2)

Exam 22: Myelodysplastic Syndromes

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An unknown cell possesses the following characteristics: blast-like characteristics including open chromatin pattern, prominent nucleoli, absence of granules and a high N:C ratio.Based on this information, what is the most probable identity of the cell?

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Question 1

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Which of the following MDS/MPDclassifications includes the immunophenotype CD33, CD13 + MPO +?

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Question 2

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Which of the following represents the granularity pattern of an abnormal in MDS?

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Question 3

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All of the following are included in the SHOMDS/MPD family except:

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Question 4

Explain the IPSS score system for prognosis and treatment of MDS.

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Question 5

Which of the following is considered an MDS/MPD variant in the WHO classification?

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Question 6

The WHO classification system for each subgroup of myelodysplastic syndrome is based on which characteristics?

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Question 7

A patient blood smear shows oval macrocytes, a dimorphic population, and basophilic stippling.There are also 6% blasts in the peripheral blood.What is the presumptive classification based on these findings?

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Question 8

Which WHO classification for MDS is best supported when the peripheral blood shows a general cytopenia, 5-19% blasts with Auer rods, and less than 1 x10⁹ /L monocytes?

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Question 9

A 60-year-old patient visits his general practitioner because of fatigue and unexplained bruising.Physical examination revealed a frail, thin, pale man with widespread bruising.A CBC is ordered, and comes back abnormal.Peripheral blood smear examination revealed abnormal granularity of platelets and leukocytes.Red cells appear dimorphic.Bone marrow analysis is performed, and there were 20% ringed sideroblasts with dysplastic changes in RBC and WBC precursors.No cytogenetic abnormalities were detected.Based on this information, what is a probable diagnosis?

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Question 10

A patient presents with general anemia and rare or no blasts.The bone marrow smear reveals 3% blasts, no Auer rods and 12% ringed sideroblasts.Which MDS classification is the associated with these findings?

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Question 11

Which type of blasts contains fewer than 20 primary granules in the cytoplasm, has a centralized nucleus, and can be found in both AML and MDS?

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Question 12

The 5q-syndrome frequently shows dysplasia in which cell lineage?

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Question 13

Explain how the FAB and WHO classifications of the MDS differ.

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Question 14

Many of the myelodysplastic syndromes share a common cytogenetic abnormality.What is it?

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Question 15

Which of the following IPSS scores has the highest survival rate in MDS?

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Question 16

Which test or tests support the theory that the abnormal cells in MDS are clones derived from an abnormal pluripotent stem cell?

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Question 17

Which of the six WHO MDS subgroups contains two or more cytopenias, rare or no blasts, less than 1 x 10⁹ /L monocytes in the peripheral blood and less than 5% blasts and less than 15% ringed sideroblasts in the bone marrow?

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Question 18

The chromosomal abnormalities present in most cases of MDS are located on which of the following chromosomes?

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Question 19

According to the WHO classification, how many blasts must be present in the bone marrow to classify a patient with acute leukemia?

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Question 20

Showing 1 - 20 of 33

Exam 22: Myelodysplastic Syndromes

An unknown cell possesses the following characteristics: blast-like characteristics including open chromatin pattern, prominent nucleoli, absence of granules and a high N:C ratio.Based on this information, what is the most probable identity of the cell?

Which of the following MDS/MPDclassifications includes the immunophenotype CD33, CD13 + MPO +?

Which of the following represents the granularity pattern of an abnormal in MDS?

All of the following are included in the SHOMDS/MPD family except:

Explain the IPSS score system for prognosis and treatment of MDS.

Which of the following is considered an MDS/MPD variant in the WHO classification?

The WHO classification system for each subgroup of myelodysplastic syndrome is based on which characteristics?

A patient blood smear shows oval macrocytes, a dimorphic population, and basophilic stippling.There are also 6% blasts in the peripheral blood.What is the presumptive classification based on these findings?

Which WHO classification for MDS is best supported when the peripheral blood shows a general cytopenia, 5-19% blasts with Auer rods, and less than 1 x109 /L monocytes?

A patient presents with general anemia and rare or no blasts.The bone marrow smear reveals 3% blasts, no Auer rods and 12% ringed sideroblasts.Which MDS classification is the associated with these findings?

Which type of blasts contains fewer than 20 primary granules in the cytoplasm, has a centralized nucleus, and can be found in both AML and MDS?

The 5q-syndrome frequently shows dysplasia in which cell lineage?

Explain how the FAB and WHO classifications of the MDS differ.

Many of the myelodysplastic syndromes share a common cytogenetic abnormality.What is it?

Which of the following IPSS scores has the highest survival rate in MDS?

Which test or tests support the theory that the abnormal cells in MDS are clones derived from an abnormal pluripotent stem cell?

Which of the six WHO MDS subgroups contains two or more cytopenias, rare or no blasts, less than 1 x 109 /L monocytes in the peripheral blood and less than 5% blasts and less than 15% ringed sideroblasts in the bone marrow?

The chromosomal abnormalities present in most cases of MDS are located on which of the following chromosomes?

According to the WHO classification, how many blasts must be present in the bone marrow to classify a patient with acute leukemia?

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

Filters

Which WHO classification for MDS is best supported when the peripheral blood shows a general cytopenia, 5-19% blasts with Auer rods, and less than 1 x10⁹ /L monocytes?

Which of the six WHO MDS subgroups contains two or more cytopenias, rare or no blasts, less than 1 x 10⁹ /L monocytes in the peripheral blood and less than 5% blasts and less than 15% ringed sideroblasts in the bone marrow?