Question 1

Which of the following best describes the effect of aspirin on platelets, and for how long does the effect last?

Accepted Answer

A) ADP receptor blockade; 5 days 
B) Thrombocytosis; 7 days 
C) Inactivation of cyclooxygenase; 7 days 
D) Thrombocytopenia; 7 days 
A) ADP receptor blockade; 5 days 
B) Thrombocytosis; 7 days 
C) Inactivation of cyclooxygenase; 7 days 
D) Thrombocytopenia; 7 days C

Question 2

What would be the expected laboratory results in a patient with thrombocytopenia?

Accepted Answer

A) Platelet counts 9/L 
B) Bleeding time normal 
C) PT and APTT abnormally prolonged 
D) Fibrinogen decreased 
A) Platelet counts 9/L 
B) Bleeding time normal 
C) PT and APTT abnormally prolonged 
D) Fibrinogen decreased A

Question 3

Predict the typical expected results of clot-based PT in a patient with a platelet defect.

Accepted Answer

A) Prolonged 
B) Normal 
C) Shortened 
D) Cannot be determined 
A) Prolonged 
B) Normal 
C) Shortened 
D) Cannot be determined B

Question 4

Which of the following characteristics differentiate chronic ITP from acute ITP?

Accepted Answer

A) Platelet counts are less than 20 x 109/L in chronic ITP. 
B) Chronic ITP has a 3:1 gender predilection in females. 
C) Duration in chronic ITP is 2-6 weeks. 
D) Lymphocytosis is common in chronic ITP. 
A) Platelet counts are less than 20 x 109/L in chronic ITP. 
B) Chronic ITP has a 3:1 gender predilection in females. 
C) Duration in chronic ITP is 2-6 weeks. 
D) Lymphocytosis is common in chronic ITP.

Question 5

When petechiae and ecchymoses are found in a higher-than-normal number with less-than-usual trauma, the condition is called which of the following?

Accepted Answer

A) Hematoma 
B) Purpura 
C) Easy bruisability 
D) Excess bleeding 
A) Hematoma 
B) Purpura 
C) Easy bruisability 
D) Excess bleeding

Question 6

Minimum screening tests that should be considered in the evaluation of abnormal bleeding is/are which of the following?

Accepted Answer

A) Thrombin time 
B) Fibrinogen level 
C) Factor studies 
D) Platelet count, PT, APTT 
A) Thrombin time 
B) Fibrinogen level 
C) Factor studies 
D) Platelet count, PT, APTT

Question 7

An instrument report has a platelet count of 850 x 109/L.This would be interpreted as:

Accepted Answer

A) A normal platelet count. 
B) Thrombocytosis. 
C) Thrombocytopenia. 
D) It cannot be defined. 
A) A normal platelet count. 
B) Thrombocytosis. 
C) Thrombocytopenia. 
D) It cannot be defined.

Question 8

A patient has a splitting headache prior to his blood draw.He takes two aspirin, and his blood is drawn.Platelet aggregation studies are performed, and one comes back abnormal.Based on this information, which agonist will show an abnormal aggregation pattern?

Accepted Answer

A) Arachidonic acid 
B) Epinephrine 
C) Collagen 
D) All of the above 
A) Arachidonic acid 
B) Epinephrine 
C) Collagen 
D) All of the above

Question 9

A patient is known to be a chronic alcoholic.His blood is drawn, and his platelet count is 72 x 109/L.What is the most likely reason for this occurrence?

Accepted Answer

A) Immune-mediated thrombocytopenia 
B) Acquired hypoplasia due to alcohol consumption 
C) Dilutional thrombocytopenia due to liver dysfunction 
D) Increased destruction of platelets 
A) Immune-mediated thrombocytopenia 
B) Acquired hypoplasia due to alcohol consumption 
C) Dilutional thrombocytopenia due to liver dysfunction 
D) Increased destruction of platelets

Question 10

A 35-year-old female is hospitalized for knee replacement surgery.Preoperative blood tests reveal a platelet count of 64 x 109/L.The surgery is postponed, and the platelet count is repeated two days later.It is 48 x 109/L.All other labs appear normal.Based on this information, from what is the patient most likely suffering?

Accepted Answer

A) Acute ITP 
B) Chronic ITP 
C) TTP 
D) HUS 
A) Acute ITP 
B) Chronic ITP 
C) TTP 
D) HUS

Question 11

All of the following are conditions associated with reactive thrombocytosis except:

Accepted Answer

A) Acute hemorrhage. 
B) Post splenectomy. 
C) Chronic idiopathic myelofibrosis. 
D) Iron deficiency anemia. 
A) Acute hemorrhage. 
B) Post splenectomy. 
C) Chronic idiopathic myelofibrosis. 
D) Iron deficiency anemia.

Question 12

What laboratory tests are used to assess disorders of primary hemostasis? Secondary hemostasis?

Accepted Answer

-Primary Hemostasis: bleeding

Question 13

A patient is exhibiting multiple pinpoint hemorrhages on his upper torso.This would be described as:

Accepted Answer

A) Hematomas. 
B) Ecchymoses. 
C) Purpura. 
D) Petechiae. 
A) Hematomas. 
B) Ecchymoses. 
C) Purpura. 
D) Petechiae.

Question 14

A peripheral blood smear of a patient reveals many giant platelets.Platelet function tests all show normal aggregation with the exception of ristocetin.From what is the patient most likely suffering?

Accepted Answer

A) Glanzmann's thrombasthenia 
B) Bernard-Soulier syndrome 
C) Storage pool disease 
D) Wiskott-Aldrich syndrome 
A) Glanzmann's thrombasthenia 
B) Bernard-Soulier syndrome 
C) Storage pool disease 
D) Wiskott-Aldrich syndrome

Question 15

What is a common etiology of ITP in children?

Accepted Answer

A) Tooth extraction 
B) Easy bruising syndrome 
C) Vasculitis 
D) Chickenpox 
A) Tooth extraction 
B) Easy bruising syndrome 
C) Vasculitis 
D) Chickenpox

Question 16

Which of the following contributes to the pathogenesis of Bernard-Soulier syndrome?

Accepted Answer

A) Abnormal glycoprotein Ib/IX complex 
B) Abnormal glycoprotein IIb/IIIa 
C) High platelet count 
D) Low fibrinogen levels 
A) Abnormal glycoprotein Ib/IX complex 
B) Abnormal glycoprotein IIb/IIIa 
C) High platelet count 
D) Low fibrinogen levels

Question 17

How do hematologic disorders contribute to the pathogenesis of thrombocytopenia?

Accepted Answer

Malignancies contribute to ins

Question 18

Which of the following physical symptoms are associated with scurvy?

Accepted Answer

A) Hemangiomas 
B) Ecchymoses 
C) Bleeding into joints and muscles 
D) Purpura fulminans 
A) Hemangiomas 
B) Ecchymoses 
C) Bleeding into joints and muscles 
D) Purpura fulminans

Question 19

Describe the following, and indicate where they are typically seen (disorders of primary hemostasis or secondary hemostasis).
A)Petechiae
B)Purpura
C)Ecchymoses
D)Hematomas

Accepted Answer

Petechiae: purple pinpoint hemorrhages b

Question 20

Increased risk of bleeding into the central nervous system occurs with a platelet count of:

Accepted Answer

A) 800 x 109/L. 
B) 200 x 109/L. 
C) 150 x 109/L. 
D) 30 x 109/L. 
A) 800 x 109/L. 
B) 200 x 109/L. 
C) 150 x 109/L. 
D) 30 x 109/L.

Exam 30: Disorders of Primary Hemostasis

Which of the following best describes the effect of aspirin on platelets, and for how long does the effect last?

What would be the expected laboratory results in a patient with thrombocytopenia?

Predict the typical expected results of clot-based PT in a patient with a platelet defect.

Which of the following characteristics differentiate chronic ITP from acute ITP?

When petechiae and ecchymoses are found in a higher-than-normal number with less-than-usual trauma, the condition is called which of the following?

Minimum screening tests that should be considered in the evaluation of abnormal bleeding is/are which of the following?

An instrument report has a platelet count of 850 x 109/L.This would be interpreted as:

A patient has a splitting headache prior to his blood draw.He takes two aspirin, and his blood is drawn.Platelet aggregation studies are performed, and one comes back abnormal.Based on this information, which agonist will show an abnormal aggregation pattern?

A patient is known to be a chronic alcoholic.His blood is drawn, and his platelet count is 72 x 109/L.What is the most likely reason for this occurrence?

All of the following are conditions associated with reactive thrombocytosis except:

What laboratory tests are used to assess disorders of primary hemostasis? Secondary hemostasis?

A patient is exhibiting multiple pinpoint hemorrhages on his upper torso.This would be described as:

A peripheral blood smear of a patient reveals many giant platelets.Platelet function tests all show normal aggregation with the exception of ristocetin.From what is the patient most likely suffering?

What is a common etiology of ITP in children?

Which of the following contributes to the pathogenesis of Bernard-Soulier syndrome?

How do hematologic disorders contribute to the pathogenesis of thrombocytopenia?

Which of the following physical symptoms are associated with scurvy?

Describe the following, and indicate where they are typically seen (disorders of primary hemostasis or secondary hemostasis). A)Petechiae B)Purpura C)Ecchymoses D)Hematomas

Increased risk of bleeding into the central nervous system occurs with a platelet count of:

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

Filters

A patient is known to be a chronic alcoholic.His blood is drawn, and his platelet count is 72 x 10⁹/L.What is the most likely reason for this occurrence?