Question 1

Acute blood loss can cause bone marrow hyperplasia.What factor will determine the ultimate effect of this pathologic state?

Accepted Answer

A) Ineffective hematopoiesis 
B) Severity of the blood loss 
C) Severity and duration of the blood loss 
D) Bone marrow activity 
A) Ineffective hematopoiesis 
B) Severity of the blood loss 
C) Severity and duration of the blood loss 
D) Bone marrow activity C

Question 2

List four causes of a hyperplastic marrow.

Accepted Answer

1.Acute blood loss causes transient erythrocytosis.
2.Increased proliferation of monoclonal or polyclonal populations of hematopoietic cells, such as leukemia
3.Ineffective hematopoiesis.Example: Vitamin B₁₂ deficiency.
4.Abnormal stimulation or abnormal response to stimulation of stem cells/progenitors from internal or external stimulants.

Question 3

A characteristic which defines a tissue as primary vs.secondary lymphoid tissue is:

Accepted Answer

A) Presence of activated cells in primary and resting cells in secondary lymphoid tissue. 
B) Quantity of cells in each. 
C) T cells in primary and B cells in secondary tissue. 
D) Ability of the lymphoid cells to respond to antigens. 
A) Presence of activated cells in primary and resting cells in secondary lymphoid tissue. 
B) Quantity of cells in each. 
C) T cells in primary and B cells in secondary tissue. 
D) Ability of the lymphoid cells to respond to antigens. D

Question 4

Track the path of maturation of the T lymphocyte.

Accepted Answer

Precursor T cells leave the bone marrow

Question 5

Where in the body does maturation of T lymphocytes take place?

Accepted Answer

A) Lymph node 
B) Bone marrow 
C) Spleen 
D) Thymus 
A) Lymph node 
B) Bone marrow 
C) Spleen 
D) Thymus

Question 6

At what point during fetal development does the bone marrow become the primary organ of hematopoiesis?

Accepted Answer

A) 3 months' gestation 
B) 14 days' gestation 
C) Birth 
D) 6 months' gestation 
A) 3 months' gestation 
B) 14 days' gestation 
C) Birth 
D) 6 months' gestation

Question 7

Normal proliferation of hematopoietic cells in adulthood takes place at what location?

Accepted Answer

A) Peripheral blood 
B) Bone marrow 
C) Stroma 
D) Liver 
A) Peripheral blood 
B) Bone marrow 
C) Stroma 
D) Liver

Question 8

Which of the following sets of organs has the capability of extramedullary hematopoiesis?

Accepted Answer

A) Thymus and lymph nodes 
B) Thymus and bone marrow 
C) Liver and spleen 
D) Liver and bone marrow 
A) Thymus and lymph nodes 
B) Thymus and bone marrow 
C) Liver and spleen 
D) Liver and bone marrow

Question 9

The primary sites lymphoid tissue includes:

Accepted Answer

A) Bone marrow, spleen, and liver. 
B) Bone marrow, thymus, and liver. 
C) Thymus, spleen, and lymph nodes. 
D) Thymus, bone marrow, and lymph nodes. 
A) Bone marrow, spleen, and liver. 
B) Bone marrow, thymus, and liver. 
C) Thymus, spleen, and lymph nodes. 
D) Thymus, bone marrow, and lymph nodes.

Question 10

Peyer's patches are an example of:

Accepted Answer

A) Primary lymphoid tissue. 
B) Secondary lymphoid tissue. 
C) Splenic tissue. 
D) Medullary tissue. 
A) Primary lymphoid tissue. 
B) Secondary lymphoid tissue. 
C) Splenic tissue. 
D) Medullary tissue.

Question 11

Explain how the bone marrow receives nutrients to survive.

Accepted Answer

The bone marrow receives nutrients prima

Question 12

The first sign of erythroid development in an embryo occurs in:

Accepted Answer

A) Yolk sac. 
B) AGM. 
C) Liver. 
D) Lymph node. 
A) Yolk sac. 
B) AGM. 
C) Liver. 
D) Lymph node.

Question 13

List and explain the function of the cells in the bone marrow stroma.

Accepted Answer

The bone marrow stroma provides a suppor

Question 14

The primary site of hematopoiesis in an adult is:

Accepted Answer

A) Bone marrow. 
B) Spleen. 
C) Liver. 
D) Lymph node. 
A) Bone marrow. 
B) Spleen. 
C) Liver. 
D) Lymph node.

Question 15

The spleenic architecture includes the largest collection in the body of which two cells?

Accepted Answer

A) Erythrocytes and platelets 
B) Lymphocytes and platelets 
C) Erythrocytes and lymphocytes 
D) Lymphocytes and macrophages 
A) Erythrocytes and platelets 
B) Lymphocytes and platelets 
C) Erythrocytes and lymphocytes 
D) Lymphocytes and macrophages

Question 16

Which of the following could cause lymphadenopathy?

Accepted Answer

A) Inflammation 
B) Infection 
C) Tumor 
D) All of the above 
A) Inflammation 
B) Infection 
C) Tumor 
D) All of the above

Question 17

A hyperplastic marrow can occur with which of the following?

Accepted Answer

A) Leukemia 
B) Post-chemotherapy 
C) Anemia 
D) Oxygen Therapy 
A) Leukemia 
B) Post-chemotherapy 
C) Anemia 
D) Oxygen Therapy

Question 18

What could be the cause of an enlarged lymph node?

Accepted Answer

A) Bone marrow tumor 
B) Infection 
C) Allergic reaction 
D) Sluggish blood flow 
A) Bone marrow tumor 
B) Infection 
C) Allergic reaction 
D) Sluggish blood flow

Question 19

Hematopoiesis in the bone marrow is chiefly controlled by which of the following?

Accepted Answer

A) The amount of fat present 
B) Stromal components 
C) Vasculature 
D) Number of osteoblasts present 
A) The amount of fat present 
B) Stromal components 
C) Vasculature 
D) Number of osteoblasts present

Question 20

Splenomegaly as a result of bone marrow failure is indicative of:

Accepted Answer

A) Liver disease. 
B) An accelerated immune response. 
C) Extramedullary hematopoiesis. 
D) Nuclear asynchrony. 
A) Liver disease. 
B) An accelerated immune response. 
C) Extramedullary hematopoiesis. 
D) Nuclear asynchrony.

Exam 4: Structure and Function of Hematopoietic Organs

Acute blood loss can cause bone marrow hyperplasia.What factor will determine the ultimate effect of this pathologic state?

List four causes of a hyperplastic marrow.

A characteristic which defines a tissue as primary vs.secondary lymphoid tissue is:

Track the path of maturation of the T lymphocyte.

Where in the body does maturation of T lymphocytes take place?

At what point during fetal development does the bone marrow become the primary organ of hematopoiesis?

Normal proliferation of hematopoietic cells in adulthood takes place at what location?

Which of the following sets of organs has the capability of extramedullary hematopoiesis?

The primary sites lymphoid tissue includes:

Peyer's patches are an example of:

Explain how the bone marrow receives nutrients to survive.

The first sign of erythroid development in an embryo occurs in:

List and explain the function of the cells in the bone marrow stroma.

The primary site of hematopoiesis in an adult is:

The spleenic architecture includes the largest collection in the body of which two cells?

Which of the following could cause lymphadenopathy?

A hyperplastic marrow can occur with which of the following?

What could be the cause of an enlarged lymph node?

Hematopoiesis in the bone marrow is chiefly controlled by which of the following?

Splenomegaly as a result of bone marrow failure is indicative of:

Introduction

Cellular Homeostasis

Hematopoiesis

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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