Question 1

Polychromatophilic red blood cells are commonly called what cell type?

Accepted Answer

A) Normoblast 
B) Prorubricyte 
C) Reticulocyte 
D) Metarubricyte 
A) Normoblast 
B) Prorubricyte 
C) Reticulocyte 
D) Metarubricyte C

Question 2

All of the following proteins interact with spectrin in the RBC membrane except:

Accepted Answer

A) Glycophorin A. 
B) Ankyrin. 
C) Protein 4.1. 
D) Actin. 
A) Glycophorin A. 
B) Ankyrin. 
C) Protein 4.1. 
D) Actin. A

Question 3

This part of the RBC membrane is essential for transporting proteins and anions across the membrane:

Accepted Answer

A) Lipids. 
B) Integral proteins. 
C) Peripheral proteins. 
D) Skeletal proteins. 
A) Lipids. 
B) Integral proteins. 
C) Peripheral proteins. 
D) Skeletal proteins. B

Question 4

In a nonanemic adult, what is the normal range for peripheral blood reticulocytes?

Accepted Answer

A) 0.5-1.0% 
B) 0.1-1.0% 
C) 2-4% 
D) 0.5-2.5% 
A) 0.5-1.0% 
B) 0.1-1.0% 
C) 2-4% 
D) 0.5-2.5%

Question 5

Which metabolic pathway protects hemoglobin from oxidation via NADH?

Accepted Answer

A) Rapoport-Luebering shunt 
B) Embden Meyerhof pathway 
C) Hexose monophosphate shunt 
D) Methemoglobin reductase pathway 
A) Rapoport-Luebering shunt 
B) Embden Meyerhof pathway 
C) Hexose monophosphate shunt 
D) Methemoglobin reductase pathway

Question 6

What effect would a deficiency in G6PD have on RBC survival?

Accepted Answer

A) It would increase the survival of the RBCs. 
B) It would decrease the survival of the RBCs. 
C) It would have no effect on the survival of the RBCs. 
D) It cannot be determined. 
A) It would increase the survival of the RBCs. 
B) It would decrease the survival of the RBCs. 
C) It would have no effect on the survival of the RBCs. 
D) It cannot be determined.

Question 7

Which of the following will have the highest concentration of erythropoietin?

Accepted Answer

A) A child 
B) A patient who has just donated a kidney 
C) An anemic patient 
D) A pregnant mother 
A) A child 
B) A patient who has just donated a kidney 
C) An anemic patient 
D) A pregnant mother

Question 8

The average RBC is what size?

Accepted Answer

A) 20-25 µm 
B) 2-3 µm 
C) 12-15 µm 
D) 7-8 µm 
A) 20-25 µm 
B) 2-3 µm 
C) 12-15 µm 
D) 7-8 µm

Question 9

What contributes to the RBC cell membrane integrity?

Accepted Answer

A) Skeletal proteins 
B) Glycolytic pathway 
C) 2,3 DPG 
D) Methemoglobin reductase 
A) Skeletal proteins 
B) Glycolytic pathway 
C) 2,3 DPG 
D) Methemoglobin reductase

Question 10

The heme moiety produced during intravascular hemolysis is excreted by the body as:

Accepted Answer

A) Biliverdin. 
B) Urobilinogen. 
C) Ferrochelatase. 
D) Iron. 
A) Biliverdin. 
B) Urobilinogen. 
C) Ferrochelatase. 
D) Iron.

Question 11

Explain how hemoglobin is catabolized by the body in both extravascular and intravascular hemolysis.

Accepted Answer

Extravascular: Hemoglobin dissociates in

Question 12

The production of 2, 3-BPG occurs in which erythrocytic metabolic pathway?

Accepted Answer

A) Embden-Meyerhof pathway 
B) Hexose monophosphate shunt 
C)  Rapoport-Luebering shunt 
D) All of the above 
A) Embden-Meyerhof pathway 
B) Hexose monophosphate shunt 
C)  Rapoport-Luebering shunt 
D) All of the above

Question 13

A blood sample has an elevated bilirubin, low haptoglobin, and low hemopexin.What is the most likely reason for this occurrence?

Accepted Answer

A) Increased extravascular hemolysis 
B) Hypersplenism 
C) Ineffective Erythropoiesis 
D) Increased intravascular hemolysis 
A) Increased extravascular hemolysis 
B) Hypersplenism 
C) Ineffective Erythropoiesis 
D) Increased intravascular hemolysis

Question 14

Red blood cell production begins with what cell?

Accepted Answer

A) Progenitor 
B) Hematopoietic stem cell 
C) CFU 
D) BFU 
A) Progenitor 
B) Hematopoietic stem cell 
C) CFU 
D) BFU

Question 15

Predict the results of erythropoietin in a patient with hypoxia.

Accepted Answer

A) It will be increased. 
B) It will be normal. 
C) It will be decreased. 
D) It cannot be determined. 
A) It will be increased. 
B) It will be normal. 
C) It will be decreased. 
D) It cannot be determined.

Question 16

What element or property contributes to the normal shape of the RBC?

Accepted Answer

A) Sodium 
B) Flexible coiled spectrin tetramers 
C) Calcium 
D) Magnesium 
A) Sodium 
B) Flexible coiled spectrin tetramers 
C) Calcium 
D) Magnesium

Question 17

The deformability of the RBC membrane is attributed to which of the following?

Accepted Answer

A) Peripheral proteins 
B) Integral proteins 
C) Sodium potassium pump 
D) Glycophorins 
A) Peripheral proteins 
B) Integral proteins 
C) Sodium potassium pump 
D) Glycophorins

Question 18

The abnormal increased influx of sodium and water in stomatocytes is due to a defect in:

Accepted Answer

A) Peripheral proteins. 
B) Integral proteins. 
C) Actin. 
D) Spectrin. 
A) Peripheral proteins. 
B) Integral proteins. 
C) Actin. 
D) Spectrin.

Question 19

A reticulocyte count is 6%.This result is:

Accepted Answer

A) Normal. 
B) Increased. 
C) Decreased. 
D) Erroneous. 
A) Normal. 
B) Increased. 
C) Decreased. 
D) Erroneous.

Question 20

The life span of a normal erythrocyte is about:

Accepted Answer

A) 9-11 days. 
B) 5-7 days. 
C) 120 days. 
D) 6 hours. 
A) 9-11 days. 
B) 5-7 days. 
C) 120 days. 
D) 6 hours.

Exam 5: The Erythrocyte

Polychromatophilic red blood cells are commonly called what cell type?

All of the following proteins interact with spectrin in the RBC membrane except:

This part of the RBC membrane is essential for transporting proteins and anions across the membrane:

In a nonanemic adult, what is the normal range for peripheral blood reticulocytes?

Which metabolic pathway protects hemoglobin from oxidation via NADH?

What effect would a deficiency in G6PD have on RBC survival?

Which of the following will have the highest concentration of erythropoietin?

The average RBC is what size?

What contributes to the RBC cell membrane integrity?

The heme moiety produced during intravascular hemolysis is excreted by the body as:

Explain how hemoglobin is catabolized by the body in both extravascular and intravascular hemolysis.

The production of 2, 3-BPG occurs in which erythrocytic metabolic pathway?

A blood sample has an elevated bilirubin, low haptoglobin, and low hemopexin.What is the most likely reason for this occurrence?

Red blood cell production begins with what cell?

Predict the results of erythropoietin in a patient with hypoxia.

What element or property contributes to the normal shape of the RBC?

The deformability of the RBC membrane is attributed to which of the following?

The abnormal increased influx of sodium and water in stomatocytes is due to a defect in:

A reticulocyte count is 6%.This result is:

The life span of a normal erythrocyte is about:

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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