Question 1

Which substance, stored in the dense bodies, is responsible for platelet activation, and is also involved in activation of the coagulation cascade?

Accepted Answer

A) PDGF 
B) ADP 
C) Calcium 
D) Thrombospondin 
A) PDGF 
B) ADP 
C) Calcium 
D) Thrombospondin C

Question 2

On average, how long does a platelet live in the peripheral circulation?

Accepted Answer

A) 6 hours 
B) 120 days 
C) 5 days 
D) 10 days 
A) 6 hours 
B) 120 days 
C) 5 days 
D) 10 days D

Question 3

The circulatory system's ability to maintain the blood as a fluid within the blood vessels and to prevent excessive blood loss upon injury is defined as which of the following?

Accepted Answer

A) Clot retraction 
B) Hemostasis 
C) Coagulation 
D) Thrombosis 
A) Clot retraction 
B) Hemostasis 
C) Coagulation 
D) Thrombosis B

Question 4

Describe megakaryocyte development, and the role of endomitosis and thrombopoietin in this process.

Accepted Answer

Platelets develop from megakaryocytes.Me

Question 5

Sequential activation of serine proteases that induce formation of insoluble blood proteins occurs in which phase of coagulation?

Accepted Answer

A) Formation of primary platelet plug 
B) Formation of secondary hemostatic plug 
C) Fibrinolysis of existing hemostatic plugs 
D) Inhibition of primary and secondary hemostatic plug formation 
A) Formation of primary platelet plug 
B) Formation of secondary hemostatic plug 
C) Fibrinolysis of existing hemostatic plugs 
D) Inhibition of primary and secondary hemostatic plug formation

Question 6

Nuclear replication without cytoplasmic division is defined as:

Accepted Answer

A) Asynchrony. 
B) Dysmyelopoiesis. 
C) Hematopoiesis. 
D) Endomitosis. 
A) Asynchrony. 
B) Dysmyelopoiesis. 
C) Hematopoiesis. 
D) Endomitosis.

Question 7

What is the typical concentration of platelets in the blood?

Accepted Answer

A) 200-600 x 108/L 
B) 150-440 x 108/L 
C) 150-440 x 109/L 
D) 250-500 x 109/L 
A) 200-600 x 108/L 
B) 150-440 x 108/L 
C) 150-440 x 109/L 
D) 250-500 x 109/L

Question 8

Which of the following is responsible for the platelet surface negative charge, and is found on the surface membrane of the interior channels?

Accepted Answer

A) Dense tubular system 
B) Open canalicular system 
C) Submembranous cytoskeleton 
D) Glycocalyx 
A) Dense tubular system 
B) Open canalicular system 
C) Submembranous cytoskeleton 
D) Glycocalyx

Question 9

Formation of a blood clot on the interior surface of an intact (unsevered) vessel is referred to as:

Accepted Answer

A) Blood coagulation. 
B) Hemostasis. 
C) Thrombosis. 
D) Fibrinolysis. 
A) Blood coagulation. 
B) Hemostasis. 
C) Thrombosis. 
D) Fibrinolysis.

Question 10

The strength of a selected agonist is defined by which of the following?

Accepted Answer

A) Location from where they are derived 
B) Their ability to induce the full range of platelet functions 
C) Their ability to interact with thromboxane A2 
D) The speed by which the platelets become activated 
A) Location from where they are derived 
B) Their ability to induce the full range of platelet functions 
C) Their ability to interact with thromboxane A2 
D) The speed by which the platelets become activated

Question 11

Secondary hemostasis involves which of the following events to further hemostasis?

Accepted Answer

A) Generation of fibrin 
B) Blood remains a liquid 
C) Fibrinolysis occurs 
D) Inhibition of platelet release reaction 
A) Generation of fibrin 
B) Blood remains a liquid 
C) Fibrinolysis occurs 
D) Inhibition of platelet release reaction

Question 12

The structures of different blood vessels are similar, but the functions are distinct.Which blood vessels serve as the major site of regulation of vascular permeability?

Accepted Answer

A) Arterioles 
B) Venules 
C) Capillaries 
D) Lumen 
A) Arterioles 
B) Venules 
C) Capillaries 
D) Lumen

Question 13

How does the vascular system contribute to hemostasis?

Accepted Answer

The vascular system contributes to hemos

Question 14

Which of the following represents a normal platelet number and morphology?

Accepted Answer

A) A platelet that is 10 µM in size, with a blood concentration of 200 x 109/L 
B) A platelet that is 80 µM in size, with a blood concentration of 8 x 109/L 
C) A platelet that is 2.5 µM in size, with a blood concentration of 250 x 109/L 
D) A platelet that is 5 µM in size, with a blood concentration of 600 x 109/L 
A) A platelet that is 10 µM in size, with a blood concentration of 200 x 109/L 
B) A platelet that is 80 µM in size, with a blood concentration of 8 x 109/L 
C) A platelet that is 2.5 µM in size, with a blood concentration of 250 x 109/L 
D) A platelet that is 5 µM in size, with a blood concentration of 600 x 109/L

Question 15

Which platelet ultrastructural zone has the functions of secretion, storage, and lipid metabolism?

Accepted Answer

A) Peripheral zone 
B) Structural zone 
C) Organelle zone 
D) Membrane systems 
A) Peripheral zone 
B) Structural zone 
C) Organelle zone 
D) Membrane systems

Question 16

Platelets are derived from which of the following?

Accepted Answer

A) Monoblasts 
B) Pronormoblasts 
C) Lymphoblasts 
D) Megakaryocytes 
A) Monoblasts 
B) Pronormoblasts 
C) Lymphoblasts 
D) Megakaryocytes

Question 17

Correlate blood vessel histology to vessel type and function in hemostasis.

Accepted Answer

Tunica adventitia: thick outer layer of

Question 18

Which of the following substances is found in all three layers of the blood vessel?

Accepted Answer

A) Fibroblasts 
B) Collagen 
C) Laminins 
D) Glycoproteins 
A) Fibroblasts 
B) Collagen 
C) Laminins 
D) Glycoproteins

Question 19

The formation of thromboxane A2 in the activated platelet:

Accepted Answer

A) Is needed for platelets to adhere to collagen. 
B) Assists in the secretion of granule contents. 
C) Requires the enzyme cyclo-oxygenase. 
D) Requires von Willebrand factor. 
A) Is needed for platelets to adhere to collagen. 
B) Assists in the secretion of granule contents. 
C) Requires the enzyme cyclo-oxygenase. 
D) Requires von Willebrand factor.

Question 20

All of the following are considered major players in coagulation except:

Accepted Answer

A) Platelets. 
B) Procoagulant inhibitors. 
C) Heparan. 
D) Serine proteases. 
A) Platelets. 
B) Procoagulant inhibitors. 
C) Heparan. 
D) Serine proteases.

Exam 28: Primary Hemostasis

Which substance, stored in the dense bodies, is responsible for platelet activation, and is also involved in activation of the coagulation cascade?

On average, how long does a platelet live in the peripheral circulation?

The circulatory system's ability to maintain the blood as a fluid within the blood vessels and to prevent excessive blood loss upon injury is defined as which of the following?

Describe megakaryocyte development, and the role of endomitosis and thrombopoietin in this process.

Sequential activation of serine proteases that induce formation of insoluble blood proteins occurs in which phase of coagulation?

Nuclear replication without cytoplasmic division is defined as:

What is the typical concentration of platelets in the blood?

Which of the following is responsible for the platelet surface negative charge, and is found on the surface membrane of the interior channels?

Formation of a blood clot on the interior surface of an intact (unsevered) vessel is referred to as:

The strength of a selected agonist is defined by which of the following?

Secondary hemostasis involves which of the following events to further hemostasis?

The structures of different blood vessels are similar, but the functions are distinct.Which blood vessels serve as the major site of regulation of vascular permeability?

How does the vascular system contribute to hemostasis?

Which of the following represents a normal platelet number and morphology?

Which platelet ultrastructural zone has the functions of secretion, storage, and lipid metabolism?

Platelets are derived from which of the following?

Correlate blood vessel histology to vessel type and function in hemostasis.

Which of the following substances is found in all three layers of the blood vessel?

The formation of thromboxane A2 in the activated platelet:

All of the following are considered major players in coagulation except:

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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