A routine CBC is ordered on a patient.Results are as follows: -WBC count = 22.0 x 109/L -PLT count = 957 x 109/L -RBC count = 5.00 x 1012/L -PB smear = moderate platelet clumping and giant platelets noted These results are characteristic of which disorder?

A) CIMF B) ET C) PV D) CML A) CIMF B) ET C) PV D) CML

Exam 21: Myeloproliferative Disorders

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A known CML patient's blood is received in the lab for a routine CBC.The technologist counts 55% blasts in his smear.What is the most likely reason for this occurrence? The patient is in:

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Question 1

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Which of the following tests would help differentiate ET from other causes of thrombocytosis?

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Question 2

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CML is characterized by which of the following?

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Question 3

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The characteristic poikilocyte often seen in the peripheral blood of patients with CIMF that is indicative of extramedullary hematopoiesis is:

(Multiple Choice)

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Question 4

The myeloproliferative disorder best described by increased leukocytes, immature granulocytes, and decreased LAP with the Philadelphia chromosome present is which of the following?

(Multiple Choice)

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Question 5

Explain how a variant of CML is identified utilizing laboratory values.

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Question 6

What cell appears to be the primary site for the defect in MPD?

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Question 7

A 45-year-old patient visits his physician for a routine examination to address his hypertension.The patient has prominent splenomegaly and rosy cheeks.He is also a smoker.Lab values are: -EPO: elevated; -WBC count: 18.4 x 10⁹/L4; -RBC count: 6.84 x 10¹²/L; -PLT count: 705 x10⁹/L. Based on these findings, what would you expect to find in the bone marrow?

(Multiple Choice)

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Question 8

A routine CBC is ordered on a patient.Results are as follows: -WBC count = 22.0 x 10⁹/L -PLT count = 957 x 10⁹/L -RBC count = 5.00 x 10¹²/L -PB smear = moderate platelet clumping and giant platelets noted These results are characteristic of which disorder?

(Multiple Choice)

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Question 9

Which of the following test results is most consistent with a diagnosis of CIMF?

(Multiple Choice)

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Question 10

Increased sensitivity to which cytokine(s) is thought to be partially responsible for the increased megakaryocyte proliferation of ET?

(Multiple Choice)

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Question 11

Which of the following would be the best way to differentiate a myeloproliferative disorder from a myelodysplastic disorder?

(Multiple Choice)

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Question 12

What is the first step in identifying a variant of CML?

(Multiple Choice)

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Question 13

What is the role of PDGF in CIMF?

(Multiple Choice)

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Question 14

A patient's CBC revealed the following: marked leukocytosis with an increased number of immature granulocytes.A few promyelocytes and blasts were seen.There were also an increased number of eosinophils and basophils with rare immature forms.The hemoglobin and hematocrit were normal but platelets were slightly decreased.Which is disorder is associated with these findings?

(Multiple Choice)

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Question 15

What is the significance of detecting only the G6PD A isoenzyme in a G6PD heterozygote patient with a myeloproliferative disorder?

(Multiple Choice)

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Question 16

Which is a characteristic of ET that would help distinguish it from reactive thrombocytosis?

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Question 17

Which is found in >90% of cases of PV and promotes EPO receptor activation?

(Multiple Choice)

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Question 18

Which myeloproliferative disorder typically produces a dramatic increase in all cell lines?

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Question 19

Which age range is nearest to the peak incidence of CML?

(Multiple Choice)

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Question 20

Showing 1 - 20 of 41

Exam 21: Myeloproliferative Disorders

A known CML patient's blood is received in the lab for a routine CBC.The technologist counts 55% blasts in his smear.What is the most likely reason for this occurrence? The patient is in:

Which of the following tests would help differentiate ET from other causes of thrombocytosis?

CML is characterized by which of the following?

The characteristic poikilocyte often seen in the peripheral blood of patients with CIMF that is indicative of extramedullary hematopoiesis is:

The myeloproliferative disorder best described by increased leukocytes, immature granulocytes, and decreased LAP with the Philadelphia chromosome present is which of the following?

Explain how a variant of CML is identified utilizing laboratory values.

What cell appears to be the primary site for the defect in MPD?

A routine CBC is ordered on a patient.Results are as follows: -WBC count = 22.0 x 109/L -PLT count = 957 x 109/L -RBC count = 5.00 x 1012/L -PB smear = moderate platelet clumping and giant platelets noted These results are characteristic of which disorder?

Which of the following test results is most consistent with a diagnosis of CIMF?

Increased sensitivity to which cytokine(s) is thought to be partially responsible for the increased megakaryocyte proliferation of ET?

Which of the following would be the best way to differentiate a myeloproliferative disorder from a myelodysplastic disorder?

What is the first step in identifying a variant of CML?

What is the role of PDGF in CIMF?

What is the significance of detecting only the G6PD A isoenzyme in a G6PD heterozygote patient with a myeloproliferative disorder?

Which is a characteristic of ET that would help distinguish it from reactive thrombocytosis?

Which is found in >90% of cases of PV and promotes EPO receptor activation?

Which myeloproliferative disorder typically produces a dramatic increase in all cell lines?

Which age range is nearest to the peak incidence of CML?

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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A routine CBC is ordered on a patient.Results are as follows: -WBC count = 22.0 x 10⁹/L -PLT count = 957 x 10⁹/L -RBC count = 5.00 x 10¹²/L -PB smear = moderate platelet clumping and giant platelets noted These results are characteristic of which disorder?