Question 1

Which of the following is an expected finding regarding the morphology of an activated lymphocyte that is different from a normal lymphocyte?

Accepted Answer

A) Oval nucleus 
B) Prominent nucleoli 
C) Abundant cytoplasm 
D) Clumped chromatin 
A) Oval nucleus 
B) Prominent nucleoli 
C) Abundant cytoplasm 
D) Clumped chromatin C

Question 2

Compare and contrast X-linked SCID and autosomal SCID.

Accepted Answer

Classic X-linked SCID accounts for 45% of all cases.It is characterized by an absence of T lymphocytes and a hypoplastic thymus.
Autosomal SCID is caused by an ADA adenosine deaminase) deficiency.It inhibits normal B and T cell development.

Question 3

Lymphocytosis is found about 1 week after symptoms appear in infectious mononucleosis and lymphocytes remain elevated for 2-8 weeks.What morphologic characteristics are present in the blood smear?

Accepted Answer

A) Leukemic lymphoblasts 
B) Reactive lymphocytes with mild thrombocytopenia 
C) Decreased lymphocytes 
D) Homogeneous lymphocyte population 
A) Leukemic lymphoblasts 
B) Reactive lymphocytes with mild thrombocytopenia 
C) Decreased lymphocytes 
D) Homogeneous lymphocyte population B

Question 4

Correlate each disorder with the following: 
1.population (s) most affected by it; 
2.whether it produces a lymphocytosis or lymphocytopenia; 
3.morphology associated with each.
4.pathophysiology of the infection.
A)Infectious mononucleosis
B)Whooping cough
C)Toxoplasmosis
D)CMV infection

Accepted Answer

Infectious mononucleosis
1.Children, tee

Question 5

All of the following are expected findings of AIDS except:

Accepted Answer

A) Lymphocytopenia. 
B) Leukocytopenia. 
C) Anemia. 
D) Thrombocytosis. 
A) Lymphocytopenia. 
B) Leukocytopenia. 
C) Anemia. 
D) Thrombocytosis.

Question 6

What are the most common laboratory findings in CMV infection in the newborn?

Accepted Answer

A) Thrombocytopenia and hemolytic anemia 
B) Leukocytosis 
C) Positive heterophile agglutinin test. 
D) Viral DNA assay is negative. 
A) Thrombocytopenia and hemolytic anemia 
B) Leukocytosis 
C) Positive heterophile agglutinin test. 
D) Viral DNA assay is negative.

Question 7

Diagnosis of an active toxoplasmosis infection is established by what comparison?

Accepted Answer

A) Molecular tests 
B) Heterophile antibody test 
C) Biopsy of lymph nodes from various sites 
D) Rising titer and seroconversion of antibodies to Toxoplasma gondi 
A) Molecular tests 
B) Heterophile antibody test 
C) Biopsy of lymph nodes from various sites 
D) Rising titer and seroconversion of antibodies to Toxoplasma gondi

Question 8

Which of the following infectious agents can be transmitted from mother to a growing fetus and can result in physically and mentally impaired development?

Accepted Answer

A) Bordetella pertussis 
B) Toxoplasma gondii 
C) Coxsackievirus A 
D) Clostridium botulinum 
A) Bordetella pertussis 
B) Toxoplasma gondii 
C) Coxsackievirus A 
D) Clostridium botulinum

Question 9

Bordetella pertussis is characterized by rapid peripheral lymphocytosis and decreased cellularity of the lymph nodes.What can explain this phenomenom?

Accepted Answer

A) Loss of homing of B cells to lymphoid tissues 
B) Loss of homing of T cells to lymphoid tissue 
C) Abnormal homing of lymphocytes to the bone marrow 
D) Increase of L-selectin expression by T cells 
A) Loss of homing of B cells to lymphoid tissues 
B) Loss of homing of T cells to lymphoid tissue 
C) Abnormal homing of lymphocytes to the bone marrow 
D) Increase of L-selectin expression by T cells

Question 10

Correlate antibody titers with the stage of infection.What antibody titer excludes current infection?

Accepted Answer

Current infection: EBV-CA IgG: >1:60; EB

Question 11

An unknown patient blood sample has the following results: WBC count = 5 x 109/L with 70% lymphocytes.What term describes this condition? Name a disease in which this is seen.

Accepted Answer

The patient has an absolute ly

Question 12

A 5-year-old patient is suspected of having infectious mononucleosis.The patient's blood smear reveals 55% reactive lymphocytes along with a WBC count of 15 x 109/L.The heterophile antibody test is negative.IgG and IgM antibodies to EBV both come back positive.What is the best explanation for these results?

Accepted Answer

A) 50% of children under the age of 10 do not have a positive heterophile test when infected with EBV. 
B) The patient does not have EBV but rather acute lymphoid leukemia. 
C) The serologic tests are false positive for IgG and IgM antibodies to EBV. 
D) The heterophile test is never positive in children under 10 years of age. 
A) 50% of children under the age of 10 do not have a positive heterophile test when infected with EBV. 
B) The patient does not have EBV but rather acute lymphoid leukemia. 
C) The serologic tests are false positive for IgG and IgM antibodies to EBV. 
D) The heterophile test is never positive in children under 10 years of age.

Question 13

What clinical condition is included in the case definition for HIV infection by the Centers for Disease Control and Prevention?

Accepted Answer

A) Bordetella pertussis 
B) Infectious mononucleosis 
C) Kaposi's sarcoma 
D) Plasmacytosis 
A) Bordetella pertussis 
B) Infectious mononucleosis 
C) Kaposi's sarcoma 
D) Plasmacytosis

Question 14

Which of the following is used as a screening test for infectious mononucleosis?

Accepted Answer

A) Heterophile antibody test 
B) EBV IgG and IgM tests 
C) HBsAg 
D) ANA IFA 
A) Heterophile antibody test 
B) EBV IgG and IgM tests 
C) HBsAg 
D) ANA IFA

Question 15

A 19-year-old male visits his physician because of a persistent cough and progressive fatigue over the last month.Physical examination reveals prominent lymphadenopathy.Laboratory analysis reveals a WBC count of 20x 109/L with 23% reactive lymphocytes.Patient serum is positive for both IgG and IgM antibodies against EBV.Based on this information, what is the patient most likely suffering from?

Accepted Answer

A) Hodgkin lymphoma 
B) Reactive leukocytosis 
C) Infectious mononucleosis 
D) Malaria 
A) Hodgkin lymphoma 
B) Reactive leukocytosis 
C) Infectious mononucleosis 
D) Malaria

Question 16

What is the agent responsible for infectious mononucleosis?

Accepted Answer

A) Toxoplasmosis 
B) CMV 
C) EBV 
D) Bordetella pertussis 
A) Toxoplasmosis 
B) CMV 
C) EBV 
D) Bordetella pertussis

Question 17

Which of the following disorders is associated with a lymphocytosis?

Accepted Answer

A) X-linked immunodeficiency syndrome 
B) AIDS 
C) Whooping cough 
D) SCID 
A) X-linked immunodeficiency syndrome 
B) AIDS 
C) Whooping cough 
D) SCID

Question 18

Bordetella pertussis and chronic lymphocytic leukemia both have increased small lymphocytes with condensed nuclear chromatin on the blood smear.What laboratory test could distinguish whooping cough from CLL?

Accepted Answer

A) Heterophile testing 
B) Biopsy of lymph nodes 
C) Molecular testing 
D) Culture and serological antibody testing 
A) Heterophile testing 
B) Biopsy of lymph nodes 
C) Molecular testing 
D) Culture and serological antibody testing

Question 19

What characteristics are associated with reactive lymphocytes?

Accepted Answer

A) Can contain vacuoles, and chromatin pattern is very fine. 
B) Can contain vacuoles, deep blue abundant cytoplasm.. 
C) Nucleus has a fine Chromatin pattern and the N:C ratio is increased. 
D) High N:C ratio with small amount of deep blue cytoplasm 
A) Can contain vacuoles, and chromatin pattern is very fine. 
B) Can contain vacuoles, deep blue abundant cytoplasm.. 
C) Nucleus has a fine Chromatin pattern and the N:C ratio is increased. 
D) High N:C ratio with small amount of deep blue cytoplasm

Question 20

Name five hematologic findings associated with HIV infections other than lymphocytopenia.

Accepted Answer

Anemia, thrombocytop

Exam 19: Nonmalignant Lymphocyte Disorders

Which of the following is an expected finding regarding the morphology of an activated lymphocyte that is different from a normal lymphocyte?

Compare and contrast X-linked SCID and autosomal SCID.

Lymphocytosis is found about 1 week after symptoms appear in infectious mononucleosis and lymphocytes remain elevated for 2-8 weeks.What morphologic characteristics are present in the blood smear?

Correlate each disorder with the following: 1.population (s) most affected by it; 2.whether it produces a lymphocytosis or lymphocytopenia; 3.morphology associated with each. 4.pathophysiology of the infection. A)Infectious mononucleosis B)Whooping cough C)Toxoplasmosis D)CMV infection

All of the following are expected findings of AIDS except:

What are the most common laboratory findings in CMV infection in the newborn?

Diagnosis of an active toxoplasmosis infection is established by what comparison?

Which of the following infectious agents can be transmitted from mother to a growing fetus and can result in physically and mentally impaired development?

Bordetella pertussis is characterized by rapid peripheral lymphocytosis and decreased cellularity of the lymph nodes.What can explain this phenomenom?

Correlate antibody titers with the stage of infection.What antibody titer excludes current infection?

An unknown patient blood sample has the following results: WBC count = 5 x 109/L with 70% lymphocytes.What term describes this condition? Name a disease in which this is seen.

What clinical condition is included in the case definition for HIV infection by the Centers for Disease Control and Prevention?

Which of the following is used as a screening test for infectious mononucleosis?

What is the agent responsible for infectious mononucleosis?

Which of the following disorders is associated with a lymphocytosis?

Bordetella pertussis and chronic lymphocytic leukemia both have increased small lymphocytes with condensed nuclear chromatin on the blood smear.What laboratory test could distinguish whooping cough from CLL?

What characteristics are associated with reactive lymphocytes?

Name five hematologic findings associated with HIV infections other than lymphocytopenia.

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

Filters

An unknown patient blood sample has the following results: WBC count = 5 x 10⁹/L with 70% lymphocytes.What term describes this condition? Name a disease in which this is seen.