Question 1

The primary storage depot for iron is in what organ?

Accepted Answer

A) Bone marrow 
B) Duodenum 
C) Stomach 
D) Liver 
A) Bone marrow 
B) Duodenum 
C) Stomach 
D) Liver D

Question 2

Differentiate primary and secondary hemochromatosis?

Accepted Answer

Primary hemochromatosis is the hereditary form of hemochromatosis that results from mutations in the HFE and other genes.The secondary form of hemochromatosis is due to a disease process, drugs, or toxins.

Question 3

Explain the difference in the chemical composition of hemosiderin and ferritin.

Accepted Answer

Hemosiderin is an amalgam of iron, proteins, lipids, and carbohydrates.Ferritin is composed of polypeptides arranged in a spherical shell.Iron atoms are stored in the shell.

Question 4

The hereditary form of sideroblastic anemia is most commonly due to:

Accepted Answer

A) Decreased hepcidin synthesis. 
B) Mutation of the HFE gene. 
C) Abnormal ALAS. 
D) Increased absorption of iron. 
A) Decreased hepcidin synthesis. 
B) Mutation of the HFE gene. 
C) Abnormal ALAS. 
D) Increased absorption of iron.

Question 5

A storage form of iron is:

Accepted Answer

A) Pappenheimer bodies. 
B) Hemoglobin. 
C) Ferritin. 
D) Transferrin. 
A) Pappenheimer bodies. 
B) Hemoglobin. 
C) Ferritin. 
D) Transferrin.

Question 6

Choose the correct progression of iron-deficiency anemia from the choices below.

Accepted Answer

A) Storage depletion, iron-poor hemoglobin production, transport depletion 
B) Storage depletion, transport depletion, iron-poor hemoglobin production 
C) Iron-poor hemoglobin production, transport depletion, storage depletion 
D) Iron-poor hemoglobin production, storage depletion, transport depletion 
A) Storage depletion, iron-poor hemoglobin production, transport depletion 
B) Storage depletion, transport depletion, iron-poor hemoglobin production 
C) Iron-poor hemoglobin production, transport depletion, storage depletion 
D) Iron-poor hemoglobin production, storage depletion, transport depletion

Question 7

Explain how lead inhibits heme synthesis.

Accepted Answer

Lead passes to the bone marrow where it

Question 8

How is sideroblastic anemia confirmed by laboratory analysis? Explain your answer.

Accepted Answer

Sideroblastic anemia results from distur

Question 9

All of the following disorders will have normal-to-elevated ferritin levels except:

Accepted Answer

A) Iron-deficiency anemia. 
B) Anemia of chronic disease. 
C) Sideroblastic anemia. 
D) Lead poisoning. 
A) Iron-deficiency anemia. 
B) Anemia of chronic disease. 
C) Sideroblastic anemia. 
D) Lead poisoning.

Question 10

What measurements are used in the percent saturation calculation?

Accepted Answer

A) Transferrin and ferritin 
B) Ferritin and bone marrow iron 
C) Serum iron and TIBC 
D) Serum iron and ferritin 
A) Transferrin and ferritin 
B) Ferritin and bone marrow iron 
C) Serum iron and TIBC 
D) Serum iron and ferritin

Question 11

Which laboratory test would be most helpful in differentiating iron-deficiency anemia from anemia of chronic disease?

Accepted Answer

A) Hemoglobin 
B) Serum iron 
C) Percent transferrin saturation 
D) Serum transferrin receptor 
A) Hemoglobin 
B) Serum iron 
C) Percent transferrin saturation 
D) Serum transferrin receptor

Question 12

This laboratory test measures the maximum amount of iron able to be bound to transferrin in the serum.

Accepted Answer

A) Ferritin 
B) Percent transferrin saturation 
C) Serum iron 
D) TIBC 
A) Ferritin 
B) Percent transferrin saturation 
C) Serum iron 
D) TIBC

Question 13

A 4-year-old boy who primarily eats grilled cheese sandwiches and tomato soup can suffer from iron-deficiency anemia due to:

Accepted Answer

A) Increased need. 
B) Inadequate intake. 
C) Impaired utilization. 
D) Increased need and inadequate intake. 
A) Increased need. 
B) Inadequate intake. 
C) Impaired utilization. 
D) Increased need and inadequate intake.

Question 14

Explain the absorption and assimilation of non-heme iron into hemoglobin in the RBC.

Accepted Answer

Non-heme iron is usually in the trivalen

Question 15

What reflex laboratory tests would be helpful to identify the cause of this anemia?

Accepted Answer

A) Serum iron studies 
B) vitamin B₁₂ 
C) Bone marrow aspirate 
D) Cytogenetic studies 
A) Serum iron studies 
B) vitamin B₁₂ 
C) Bone marrow aspirate 
D) Cytogenetic studies

Question 16

What is the most probable diagnosis based on these clinical findings and patient history?

Accepted Answer

A) Lead poisoning 
B) Iron-deficiency anemia 
C) Sideroblastic anemia 
D) Hereditary hemochromatosis 
A) Lead poisoning 
B) Iron-deficiency anemia 
C) Sideroblastic anemia 
D) Hereditary hemochromatosis

Question 17

Anemia of chronic disease is characterized by:

Accepted Answer

A) A block in globin synthesis. 
B) Inadequate intake of iron. 
C) A block in insertion of iron into the porphyrin ring of heme. 
D) A block in iron release from macrophages. 
A) A block in globin synthesis. 
B) Inadequate intake of iron. 
C) A block in insertion of iron into the porphyrin ring of heme. 
D) A block in iron release from macrophages.

Question 18

A defect in the HFE gene would cause which of the following to occur?

Accepted Answer

A) Increased iron absorption in the intestines 
B) Decreased iron absorption in the intestines 
C) Increased erythropoiesis in the bone marrow 
D) Increased transferrin synthesis 
A) Increased iron absorption in the intestines 
B) Decreased iron absorption in the intestines 
C) Increased erythropoiesis in the bone marrow 
D) Increased transferrin synthesis

Question 19

Iron-deficiency anemia can occur by what three mechanisms?

Accepted Answer

A) Impaired iron absorption, blood loss, inadequate iron intake 
B) ALAS deficiency, blood loss, decreased transferrin 
C) Mutation of HFE gene, decreased transferrin, increased hepcidin 
D) Inadequate iron intake, impaired iron absorption, decreased hepcidin 
A) Impaired iron absorption, blood loss, inadequate iron intake 
B) ALAS deficiency, blood loss, decreased transferrin 
C) Mutation of HFE gene, decreased transferrin, increased hepcidin 
D) Inadequate iron intake, impaired iron absorption, decreased hepcidin

Question 20

A term used to describe impaired utilization of iron as seen in ACD is:

Accepted Answer

A) Sideropenic. 
B) Sideroblastic. 
C) Sideroachrestic. 
D) Siderocyte. 
A) Sideropenic. 
B) Sideroblastic. 
C) Sideroachrestic. 
D) Siderocyte.

Exam 9: Anemias of Disordered Iron Metabolism and Heme Synthesis

The primary storage depot for iron is in what organ?

Differentiate primary and secondary hemochromatosis?

Explain the difference in the chemical composition of hemosiderin and ferritin.

The hereditary form of sideroblastic anemia is most commonly due to:

A storage form of iron is:

Choose the correct progression of iron-deficiency anemia from the choices below.

Explain how lead inhibits heme synthesis.

How is sideroblastic anemia confirmed by laboratory analysis? Explain your answer.

All of the following disorders will have normal-to-elevated ferritin levels except:

What measurements are used in the percent saturation calculation?

Which laboratory test would be most helpful in differentiating iron-deficiency anemia from anemia of chronic disease?

This laboratory test measures the maximum amount of iron able to be bound to transferrin in the serum.

A 4-year-old boy who primarily eats grilled cheese sandwiches and tomato soup can suffer from iron-deficiency anemia due to:

Explain the absorption and assimilation of non-heme iron into hemoglobin in the RBC.

What reflex laboratory tests would be helpful to identify the cause of this anemia?

What is the most probable diagnosis based on these clinical findings and patient history?

Anemia of chronic disease is characterized by:

A defect in the HFE gene would cause which of the following to occur?

Iron-deficiency anemia can occur by what three mechanisms?

A term used to describe impaired utilization of iron as seen in ACD is:

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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