Question 1

What is the percent transferrin saturation and UIBC in a patient with a serum iron of 85 ug/dL and a TIBC of 280 ug/dL?

Accepted Answer

A) 45%; 280 ug/dL 
B) 30%; 195 ug/dL 
C) 55%; 195 ug/dL 
D) 32%; 280 ug/dL 
A) 45%; 280 ug/dL 
B) 30%; 195 ug/dL 
C) 55%; 195 ug/dL 
D) 32%; 280 ug/dL

Question 2

Accumulation of heterogeneous aggregates of iron is called:

Accepted Answer

A) Hemosiderosis. 
B) Sideroblastosis. 
C) Ferritinemia. 
D) Transferrinuria. 
A) Hemosiderosis. 
B) Sideroblastosis. 
C) Ferritinemia. 
D) Transferrinuria.

Question 3

Which of the following is NOT characteristic of iron deficiency anemia?

Accepted Answer

A) Decreased ZPP 
B) Decreased serum iron 
C) Increased TIBC 
D) Decreased serum ferritin 
A) Decreased ZPP 
B) Decreased serum iron 
C) Increased TIBC 
D) Decreased serum ferritin

Question 4

Erythropoietic porphyrias are associated with:

Accepted Answer

A) Abnormal iron metabolism. 
B) Abnormal enzymes in the heme biosynthetic pathway. 
C) Abnormal globin synthesis. 
D) DMT1 mutations. 
A) Abnormal iron metabolism. 
B) Abnormal enzymes in the heme biosynthetic pathway. 
C) Abnormal globin synthesis. 
D) DMT1 mutations.

Question 5

What is the typical PB picture in a patient with stage 1 IDA?

Accepted Answer

A) Normocytic normochromic 
B) Microcytic hypochromic 
C) Macrocytic normochromic 
D) Normocytic hypochromic 
A) Normocytic normochromic 
B) Microcytic hypochromic 
C) Macrocytic normochromic 
D) Normocytic hypochromic

Question 6

A bone marrow aspirate is performed on a patient with sideroblastic anemia.The smear is stained with Prussian blue iron stain.What would be the expected findings in this patient? Iron stores:

Accepted Answer

A) Will be decreased as compared with the normal control. 
B) Will be the same as those in the normal control. 
C) Will be increased as compared with the normal control. 
D) Cannot be determined based on the diagnosis alone. 
A) Will be decreased as compared with the normal control. 
B) Will be the same as those in the normal control. 
C) Will be increased as compared with the normal control. 
D) Cannot be determined based on the diagnosis alone.

Question 7

What enzyme is responsible for reducing ferric iron to the ferrous state at the enterocyte brush border?

Accepted Answer

A) Apoferritin 
B) DcytB 
C) Ferritin 
D) Transferrin 
A) Apoferritin 
B) DcytB 
C) Ferritin 
D) Transferrin

Question 8

Iron overload exists when ferritin levels are higher than:

Accepted Answer

A) 100 ng/mL. 
B) 200 ng/mL. 
C) 50 ng/mL. 
D) 24 ng/mL. 
A) 100 ng/mL. 
B) 200 ng/mL. 
C) 50 ng/mL. 
D) 24 ng/mL.

Question 9

An unknown sample reveals a low serum iron, high TIBC, low ferritin, low hemoglobin and a microcytic hypochromic picture in the peripheral blood.Which stage of IDA is this?

Accepted Answer

A) Stage 1 IDA 
B) Stage 2 IDA 
C) Stage 3 IDA 
D) It cannot be determined based on the information given. 
A) Stage 1 IDA 
B) Stage 2 IDA 
C) Stage 3 IDA 
D) It cannot be determined based on the information given.

Question 10

Alcoholics have an increased incidence of sideroblastic anemia due to which of the following?

Accepted Answer

A) Impaired utilization of globin chains 
B) Abnormal stem cells 
C) Abnormal activity of enzymes of heme synthesis 
D) Impaired transport of iron into erythroid precursors 
A) Impaired utilization of globin chains 
B) Abnormal stem cells 
C) Abnormal activity of enzymes of heme synthesis 
D) Impaired transport of iron into erythroid precursors

Question 11

Name the molecule that is responsible for oxidizing ferrous iron to ferric iron to be combined with transferrin.

Accepted Answer

A) DCytB 
B) DMT1 
C) Ferroportin 
D) Hephaestin 
A) DCytB 
B) DMT1 
C) Ferroportin 
D) Hephaestin

Question 12

Which of the following acts as the chief regulator of iron absorption in the intestines?

Accepted Answer

A) HFE 
B) Hepcidin 
C) Duodenal cytochrome-B reductase 
D) Ferroportin 
A) HFE 
B) Hepcidin 
C) Duodenal cytochrome-B reductase 
D) Ferroportin

Question 13

Regulation of iron entering the body occurs mainly through which mechanism?

Accepted Answer

A) Transfer of iron in the enterocyte into the blood 
B) Absorption of dietary iron into the enterocyte 
C) Excretion of excess iron from the intestine into the urine 
D) Chelation of dietary iron in the intestine 
A) Transfer of iron in the enterocyte into the blood 
B) Absorption of dietary iron into the enterocyte 
C) Excretion of excess iron from the intestine into the urine 
D) Chelation of dietary iron in the intestine

Question 14

Hypochromic, microcytic anemia is found in this stage of iron deficiency:

Accepted Answer

A) 1. 
B) 2. 
C) 3. 
A) 1. 
B) 2. 
C) 3.

Question 15

The most common form of hereditary hemochromatosis is due to which gene mutation?

Accepted Answer

A) HFE 
B) hepcidin gene 
C) Ferroportin gene 
D) HJV 
A) HFE 
B) hepcidin gene 
C) Ferroportin gene 
D) HJV

Question 16

The patient was found to have normal serum iron studies.What other reflex test(s) should be done?

Accepted Answer

A) Blood lead level 
B) Porphyrin studies 
C) Reticulocte count 
D) Osmotic fragility 
A) Blood lead level 
B) Porphyrin studies 
C) Reticulocte count 
D) Osmotic fragility

Exam 9: Anemias of Disordered Iron Metabolism and Heme Synthesis

What is the percent transferrin saturation and UIBC in a patient with a serum iron of 85 ug/dL and a TIBC of 280 ug/dL?

Accumulation of heterogeneous aggregates of iron is called:

Which of the following is NOT characteristic of iron deficiency anemia?

Erythropoietic porphyrias are associated with:

What is the typical PB picture in a patient with stage 1 IDA?

A bone marrow aspirate is performed on a patient with sideroblastic anemia.The smear is stained with Prussian blue iron stain.What would be the expected findings in this patient? Iron stores:

What enzyme is responsible for reducing ferric iron to the ferrous state at the enterocyte brush border?

Iron overload exists when ferritin levels are higher than:

An unknown sample reveals a low serum iron, high TIBC, low ferritin, low hemoglobin and a microcytic hypochromic picture in the peripheral blood.Which stage of IDA is this?

Alcoholics have an increased incidence of sideroblastic anemia due to which of the following?

Name the molecule that is responsible for oxidizing ferrous iron to ferric iron to be combined with transferrin.

Which of the following acts as the chief regulator of iron absorption in the intestines?

Regulation of iron entering the body occurs mainly through which mechanism?

Hypochromic, microcytic anemia is found in this stage of iron deficiency:

The most common form of hereditary hemochromatosis is due to which gene mutation?

The patient was found to have normal serum iron studies.What other reflex test(s) should be done?

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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