Question 1

What cell lineage is characterized by the presence of CD14 on its surface?

Accepted Answer

A) Neutrophilic 
B) Eosinophilic 
C) Monocytic 
D) Lymphocytic 
A) Neutrophilic 
B) Eosinophilic 
C) Monocytic 
D) Lymphocytic C

Question 2

The lymphoid progenitor that gives rise to T, B, and NK lymphocytes is recognized as which of the following?

Accepted Answer

A) CFU_GM 
B) CLP 
C) CMP 
D) CFU-T 
A) CFU_GM 
B) CLP 
C) CMP 
D) CFU-T B

Question 3

Phagocytosis consumes a large amount of energy provided by what processes?

Accepted Answer

A) Diapedesis 
B) Erythrophagocytosis 
C) Innate immune response 
D) Aerobic and/or anaerobic glycolysis 
A) Diapedesis 
B) Erythrophagocytosis 
C) Innate immune response 
D) Aerobic and/or anaerobic glycolysis D

Question 4

Differentiate between absolute and relative concentrations of specific types of leukocytes and give an example of a condition that typically produces abnormal absolute or relative concentrations.

Accepted Answer

The relative concentration is the percen

Question 5

All of the following precursors are found in the mitotic pool except:

Accepted Answer

A) Promyelocyte. 
B) Myeloblast. 
C) Metamyelocyte. 
D) Myelocyte. 
A) Promyelocyte. 
B) Myeloblast. 
C) Metamyelocyte. 
D) Myelocyte.

Question 6

T, B, and NK lymphocytes can be differentiated by:

Accepted Answer

A) Morphology. 
B) Flow cytometry. 
C) Cytochemistry. 
D) Cytogenetic karyotype. 
A) Morphology. 
B) Flow cytometry. 
C) Cytochemistry. 
D) Cytogenetic karyotype.

Question 7

All of the following are included in the kill mechanism of neutrophils except:

Accepted Answer

A) Chemoattraction of neutrophils to infectious agent. 
B) Diapedesis of neutrophils from blood into tissues. 
C) The formation of the phagolysosome by the neutrophil. 
D) The presentation of infectious agent to monocyte for phagocytosis. 
A) Chemoattraction of neutrophils to infectious agent. 
B) Diapedesis of neutrophils from blood into tissues. 
C) The formation of the phagolysosome by the neutrophil. 
D) The presentation of infectious agent to monocyte for phagocytosis.

Question 8

A 15-year-old boy sees his physician because of a prolonged fever and swollen lymph glands.His PB smear shows 20% atypical lymphocytes with a 16 × 109LWBC count.What can you conclude from this?

Accepted Answer

A) The boy has a genetic lymphocytosis. 
B) The boy has leukemia. 
C) The boy is healthy. 
D) The boy has clinical features of infectious mononucleosis. 
A) The boy has a genetic lymphocytosis. 
B) The boy has leukemia. 
C) The boy is healthy. 
D) The boy has clinical features of infectious mononucleosis.

Question 9

A blood sample from a 40-year-old white female has a WBC count of 10.2 x 109/L and a lymphocyte percentage of 47%.What can be concluded from this?

Accepted Answer

A) The patient has both a relative and an absolute lymphocytosis. 
B) The patient has only a relative lymphocytosis. 
C) The patient has only an absolute lymphocytosis. 
D) The relative and absolute counts are normal. 
A) The patient has both a relative and an absolute lymphocytosis. 
B) The patient has only a relative lymphocytosis. 
C) The patient has only an absolute lymphocytosis. 
D) The relative and absolute counts are normal.

Question 10

List and explain the four phases of neutrophil kill function.

Accepted Answer

Phase I: Antigen causes release of chemo

Question 11

The process by which neutrophils migrate through the VEC into the tissues is known as:

Accepted Answer

A) Chemotaxis. 
B) Opsonization. 
C) Diapedesis. 
D) Phagocytosis. 
A) Chemotaxis. 
B) Opsonization. 
C) Diapedesis. 
D) Phagocytosis.

Question 12

What are three defining characteristics that would help the laboratory professional differentiate between a blast and an activated lymphocyte?

Accepted Answer

Blasts: high N:C ratio; large cell; open

Question 13

What cell has CD8 on its surface?

Accepted Answer

A) T helper cell 
B) B cell 
C) Macrophage 
D) Cytotoxic T cell 
A) T helper cell 
B) B cell 
C) Macrophage 
D) Cytotoxic T cell

Question 14

The basophil is the least plentiful cell found in the peripheral blood.What can it indicate when it is increased in the blood?

Accepted Answer

A) Infection 
B) Malignancy 
C) Inflammation 
D) Allergic reaction 
A) Infection 
B) Malignancy 
C) Inflammation 
D) Allergic reaction

Question 15

Which of the following terms is used to describe an absolute increase in the number of lymphocytes?

Accepted Answer

A) Neutropenia 
B) Eosinophilia 
C) Leukocytosis 
D) Lymphocytosis 
A) Neutropenia 
B) Eosinophilia 
C) Leukocytosis 
D) Lymphocytosis

Question 16

The commitment of a lymphocyte precursor cell to a T-lymphocyte can be defined based on:

Accepted Answer

A) Rearrangement of the gene loci for the TCR. 
B) Rearrangement of the immunoglobulin gene. 
C) Presence of CD 19 and CD 10 by flow cytometry. 
D) Presence of TdT. 
A) Rearrangement of the gene loci for the TCR. 
B) Rearrangement of the immunoglobulin gene. 
C) Presence of CD 19 and CD 10 by flow cytometry. 
D) Presence of TdT.

Question 17

An instrument printout shows a WBC count of 4.5 x 109/L with 75% neutrophils.What is the absolute neutrophil count?

Accepted Answer

A) 1.9 x 109/L 
B) 3.8 x 109/L 
C) 3.4 x 109/L 
D) 4.5 x 109/L 
A) 1.9 x 109/L 
B) 3.8 x 109/L 
C) 3.4 x 109/L 
D) 4.5 x 109/L

Question 18

What stage of neutrophil maturation is described by the following: 20 μm in size, round nucleus with lacey chromatin and several nucleoli, deep blue cytoplasm with large bluish-purple granules.

Accepted Answer

A) Promyelocyte 
B) Metamyelocyte 
C) Band neutrophil 
D) Myelocyte 
A) Promyelocyte 
B) Metamyelocyte 
C) Band neutrophil 
D) Myelocyte

Question 19

Leukocyte surface markers identify cell lineage, and are helpful in differentiating neoplastic hematologic disorders.What is one method used to identify these surface markers?

Accepted Answer

A) Chamber counts 
B) Leukocyte differential 
C) Cytogenetic methods 
D) Flow cytometry 
A) Chamber counts 
B) Leukocyte differential 
C) Cytogenetic methods 
D) Flow cytometry

Question 20

Which of the following is found on early T cell precursors?

Accepted Answer

A) CD2 
B) CD4 
C) CD8 
D) CD34 
A) CD2 
B) CD4 
C) CD8 
D) CD34

Exam 7: The Leukocyte

What cell lineage is characterized by the presence of CD14 on its surface?

The lymphoid progenitor that gives rise to T, B, and NK lymphocytes is recognized as which of the following?

Phagocytosis consumes a large amount of energy provided by what processes?

Differentiate between absolute and relative concentrations of specific types of leukocytes and give an example of a condition that typically produces abnormal absolute or relative concentrations.

All of the following precursors are found in the mitotic pool except:

T, B, and NK lymphocytes can be differentiated by:

All of the following are included in the kill mechanism of neutrophils except:

A 15-year-old boy sees his physician because of a prolonged fever and swollen lymph glands.His PB smear shows 20% atypical lymphocytes with a 16 × 109LWBC count.What can you conclude from this?

A blood sample from a 40-year-old white female has a WBC count of 10.2 x 109/L and a lymphocyte percentage of 47%.What can be concluded from this?

List and explain the four phases of neutrophil kill function.

The process by which neutrophils migrate through the VEC into the tissues is known as:

What are three defining characteristics that would help the laboratory professional differentiate between a blast and an activated lymphocyte?

What cell has CD8 on its surface?

The basophil is the least plentiful cell found in the peripheral blood.What can it indicate when it is increased in the blood?

Which of the following terms is used to describe an absolute increase in the number of lymphocytes?

The commitment of a lymphocyte precursor cell to a T-lymphocyte can be defined based on:

An instrument printout shows a WBC count of 4.5 x 109/L with 75% neutrophils.What is the absolute neutrophil count?

What stage of neutrophil maturation is described by the following: 20 μm in size, round nucleus with lacey chromatin and several nucleoli, deep blue cytoplasm with large bluish-purple granules.

Leukocyte surface markers identify cell lineage, and are helpful in differentiating neoplastic hematologic disorders.What is one method used to identify these surface markers?

Which of the following is found on early T cell precursors?

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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