Exam 16: Hemolytic Anemia: Immune Anemias

A patient is admitted with chest pain and extreme shortness of breath.Patient history is unremarkable except for ingestion of oral cefoxitin for the past 4 days.A DAT profile is positive with polyspecific AHG, negative with anti-IgG, and positive with anti-C3.The hemoglobin is 8.0 gm/dl.Based on these results, what mechanism of drug-induced hemolysis is present?

A patient with SLE shows evidence of decreased hemoglobin and ongoing hemolysis.The DAT is negative.Which of the following is the most likely explanation for these results?

2-14 days after a transfusion, a patient is cross-matched for another transfusion.Slight hemolysis and a positive DAT are found.What testing should follow?

Cold hemolytic anemia is usually due to:

The most likely cause of immediate hemolytic transfusion reaction is due to antibodies of which system?

Paroxysmal cold hemoglobinuria is associated with viral and bacterial infections in children.With what other disease(s) is it associated?

Compare the three mechanisms of drug-induced immune hemolysis.

Which of the following set of results is consistent with a diagnosis of WAIHA? Polyspecific AHG anti-IgG anti-C3 a. Positive positive negative b. Positive negative negative c. Negative positive positive d. Positive negative positive

A Group O, Rh negative woman with no evidence of antibodies delivers her first child who shows a slightly decreased hemoglobin and the presence of spherocytes on the peripheral blood film.The DAT is positive with polyspecific AHG and anti-IgG.The baby is Group A, Rh negative and is slightly jaundiced with a bilirubin of 2.1 mg/dl.What is the most likely cause of the baby's jaundice?

A patient on α-methyldopa may develop a type of drug-induced immune hemolysis that mimics what condition?

A 44 year old female presents for her routine examination.She complains of tiredness and difficulty in breathing when she exerts herself.Her DAT is positive with polyspecific AHG and anti-IgG.Her hemoglobin is 7.5 gm/dl and her indices suggest a normocytic, normochromic anemia.Her peripheral blood smear shows the presence of spherocytes.What is the most likely diagnosis?

Compare the differences in the activation of complement that lead to intravascular hemolysis or extravascular hemolysis.

A patient's hemoglobin went from a value of 13.0 gm/dl after transfusion to 10.6 gm/dl 3 days after transfusion.What is the most likely type of transfusion reaction?

Which of the following is an example of an anemia that occurs as a result of antibody development to an antigen that the individual lacks?

ABO incompatibility is associated with which type of transfusion reaction?

Paroxysmal cold hemoglobinuria is confirmed by a positive:

Acute hemolytic transfusion reaction is characterized by which of the following?

A sample demonstrates a DAT profile that is positive with polyspecific AHG, negative with anti-IgG, and positive with anti-C3.If the Donath-Landsteiner test was also positive, what should the CLS do?

Explain why the DAT profile in CAD is reactive only with polyspecific AHG and anti-C3 but not with anti-IgG.

Autoantibodies associated with CAD are directed against what antigen system?