Question 1

Which of the following are role(s) of high molecular weight kininogen?

Accepted Answer

A) Accelerates the rate of surface-dependent activation of F-XII 
B) Nonenzymatic cofactor in contact factor activation 
C) Source of bradykinin 
D) All of the above 
A) Accelerates the rate of surface-dependent activation of F-XII 
B) Nonenzymatic cofactor in contact factor activation 
C) Source of bradykinin 
D) All of the above D

Question 2

What are the roles of thrombin in coagulation?

Accepted Answer

-Platelet aggregation
-Factor activation F-V, -VIII, -XI)
-Anticoagulant activity viaPC, PS and thrombomodulin)
- Fibrin formation fibrinogen cleavage)
-Fibrin stabilization F-XIII activation)
-Fibrinolysis TAFI activation)
-Tissue repair

Question 3

Which of the following is the smallest degradation product of fibrin?

Accepted Answer

A) Fragment X 
B) Fragment Y 
C) D-dimer 
D) E fragment 
A) Fragment X 
B) Fragment Y 
C) D-dimer 
D) E fragment D

Question 4

Why is vitamin K necessary for some coagulation proteins to become functional?

Accepted Answer

A) Vitamin K activates coagulation zymogens. 
B) Vitamin K binds coagulation factors to a phospholipid surface. 
C) Vitamin K combines with VWF in the circulation. 
D) Vitamin K is required for gamma-carboxylation of glutamic acid residues. 
A) Vitamin K activates coagulation zymogens. 
B) Vitamin K binds coagulation factors to a phospholipid surface. 
C) Vitamin K combines with VWF in the circulation. 
D) Vitamin K is required for gamma-carboxylation of glutamic acid residues.

Question 5

Activation of the contact activation factors of the intrinsic pathway does not require which of the following components?

Accepted Answer

A) Vitamin K 
B) Calcium 
C) A serine protease 
D) Kinins 
A) Vitamin K 
B) Calcium 
C) A serine protease 
D) Kinins

Question 6

Compare and contrast systemic and physiologic fibrinolysis.

Accepted Answer

Physiologic fibrinolysis: highly fibrin-

Question 7

Hemostasis is dependent upon which of the following?

Accepted Answer

A) The interaction between coagulation and fibrinolysis inhibitors 
B) The interaction between platelets, coagulation proteins, and blood vessels 
C) The rate of platelet destruction 
D) the rate of endothelial cell turnover 
E) All of the above 
A) The interaction between coagulation and fibrinolysis inhibitors 
B) The interaction between platelets, coagulation proteins, and blood vessels 
C) The rate of platelet destruction 
D) the rate of endothelial cell turnover 
E) All of the above

Question 8

How does systemic fibrinolysis differ from physiologic fibrinolysis?

Accepted Answer

A) Systemic produces rapid fibrinolysis, whereas physiologic produces adequate fibrinolysis. 
B) Systemic results from improper plasminogen activation, whereas physiologic results from proper plasminogen activation. 
C) Physiologic is naturally occurring, whereas systemic results from an external trigger. 
D) Physiologic is localized to the fibrin clot, whereas systemic results in circulating plasmin. 
A) Systemic produces rapid fibrinolysis, whereas physiologic produces adequate fibrinolysis. 
B) Systemic results from improper plasminogen activation, whereas physiologic results from proper plasminogen activation. 
C) Physiologic is naturally occurring, whereas systemic results from an external trigger. 
D) Physiologic is localized to the fibrin clot, whereas systemic results in circulating plasmin.

Question 9

What reflex test should be done on a patient with an abnormal APTT who is suspected of having hemophillia?

Accepted Answer

A) Platelet function assay 
B) Factor assay 
C) Quantitative fibrinogen assay 
D) Assay for D-dimer 
A) Platelet function assay 
B) Factor assay 
C) Quantitative fibrinogen assay 
D) Assay for D-dimer

Question 10

Which of the following degrades factors V and VIII?

Accepted Answer

A) TFPI 
B) SERPINs 
C) Proteins C and S 
D) APS 
A) TFPI 
B) SERPINs 
C) Proteins C and S 
D) APS

Question 11

What is the role of vitamin K in hemostasis?

Accepted Answer

A) To promote contact factor activation 
B) To facilitate calcium binding to essential factors 
C) To initiate extrinsic pathway activation 
D) To cross-link the fibrin monomers 
A) To promote contact factor activation 
B) To facilitate calcium binding to essential factors 
C) To initiate extrinsic pathway activation 
D) To cross-link the fibrin monomers

Question 12

Which domain of the blood coagulation protein is responsible for its unique identity?

Accepted Answer

A) Signal peptide domain 
B) Catalytic domain 
C) Epidermal growth factor domain 
D) Noncatalytic domain 
A) Signal peptide domain 
B) Catalytic domain 
C) Epidermal growth factor domain 
D) Noncatalytic domain

Question 13

Platelet activation and subsequent formation of the platelet plug are involved in:

Accepted Answer

A) Primary hemostasis. 
B) Secondary hemostasis. 
C) Fibrinolysis. 
D) Inhibitory system. 
A) Primary hemostasis. 
B) Secondary hemostasis. 
C) Fibrinolysis. 
D) Inhibitory system.

Question 14

On which chromosome does the factor VIII locus reside?

Accepted Answer

A) 3 
B) 4 
C) 11 
D) X 
A) 3 
B) 4 
C) 11 
D) X

Question 15

TAFI is defined as a:

Accepted Answer

A) Procoagulant. 
B) Anticoagulant. 
C) Pro-fibrinolytic. 
D) Anti-fibrinolytic. 
A) Procoagulant. 
B) Anticoagulant. 
C) Pro-fibrinolytic. 
D) Anti-fibrinolytic.

Question 16

What is the key component in secondary hemostasis that binds the platelets into a solid plug?

Accepted Answer

A) Fibrin 
B) Tissue factor 
C) Plasminogen 
D) Thrombin 
A) Fibrin 
B) Tissue factor 
C) Plasminogen 
D) Thrombin

Question 17

Which of the following coagulation factors are found in the extrinsic pathway?

Accepted Answer

A) HK and F-XII 
B) F-XI and F-IX 
C) F-VII and TF 
D) F-X 
A) HK and F-XII 
B) F-XI and F-IX 
C) F-VII and TF 
D) F-X

Question 18

The prothrombin group includes of which of the following?

Accepted Answer

A) Factor V 
B) Factor VII 
C) Factor XII 
D) Factor VIII 
A) Factor V 
B) Factor VII 
C) Factor XII 
D) Factor VIII

Question 19

During activation of coagulation, all of the following bind to the phospholipid membrane surface forming a complex except:

Accepted Answer

A) Procoagulant zymogen (substrate). 
B) Coagulation inhibitors . 
C) Procoagulant cofactors. 
D) Activated serine protease. 
A) Procoagulant zymogen (substrate). 
B) Coagulation inhibitors . 
C) Procoagulant cofactors. 
D) Activated serine protease.

Question 20

The substance directly responsible for the physical breakdown of the thrombus is:

Accepted Answer

A) Plasmin. 
B) Plasminogen. 
C) Tissue plasminogen activator. 
D) F. 
E) ibrin. 
A) Plasmin. 
B) Plasminogen. 
C) Tissue plasminogen activator. 
D) F. 
E) ibrin.

Exam 29: Secondary Hemostasis and Fibrinolysis

Which of the following are role(s) of high molecular weight kininogen?

What are the roles of thrombin in coagulation?

Which of the following is the smallest degradation product of fibrin?

Why is vitamin K necessary for some coagulation proteins to become functional?

Activation of the contact activation factors of the intrinsic pathway does not require which of the following components?

Compare and contrast systemic and physiologic fibrinolysis.

Hemostasis is dependent upon which of the following?

How does systemic fibrinolysis differ from physiologic fibrinolysis?

What reflex test should be done on a patient with an abnormal APTT who is suspected of having hemophillia?

Which of the following degrades factors V and VIII?

What is the role of vitamin K in hemostasis?

Which domain of the blood coagulation protein is responsible for its unique identity?

Platelet activation and subsequent formation of the platelet plug are involved in:

On which chromosome does the factor VIII locus reside?

TAFI is defined as a:

What is the key component in secondary hemostasis that binds the platelets into a solid plug?

Which of the following coagulation factors are found in the extrinsic pathway?

The prothrombin group includes of which of the following?

During activation of coagulation, all of the following bind to the phospholipid membrane surface forming a complex except:

The substance directly responsible for the physical breakdown of the thrombus is:

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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