Question 1

What factor does the extrinsic pathway require that the intrinsic and common do not?

Accepted Answer

A) Vitamin K 
B) Zymogens 
C) Tissue factor 
D) tPA 
A) Vitamin K 
B) Zymogens 
C) Tissue factor 
D) tPA

Question 2

Which of the following are formed on a phospholipid surface?

Accepted Answer

A) Extrinsic Xase 
B) Intrinsic Xase 
C) Prothrombinase 
D) All of the above 
A) Extrinsic Xase 
B) Intrinsic Xase 
C) Prothrombinase 
D) All of the above

Question 3

Interpret the results below: -Patient: 12-year-old boy with unexplained bruising, swollen knee joints, and prolonged bleeding from injuries
-Screening tests:
-PT = 12.2 sec (control: 11.5-13.3 sec)/INR: 1.09
-APTT = 57 sec (control: 23-32 sec)
-Bleeding time = 5 min (control: 2-10 min)
Pending results from confirmation tests, this patient could be suffering from:

Accepted Answer

A) An intrinsic pathway problem. 
B) An extrinsic pathway problem. 
C) A primary hemostasis problem. 
D) A common pathway problem. 
A) An intrinsic pathway problem. 
B) An extrinsic pathway problem. 
C) A primary hemostasis problem. 
D) A common pathway problem.

Question 4

Which of the following is primarily responsible for neutralizing the extrinsic tenase complex?

Accepted Answer

A) TFPI 
B) SERPINs 
C) Proteins C and S 
D) APS 
A) TFPI 
B) SERPINs 
C) Proteins C and S 
D) APS

Question 5

Thrombin activity impacts coagulation by which of the following mechanism(s)?

Accepted Answer

A) Altering blood flow 
B) Positive feedback only 
C) Negative feedback only 
D) positive and negative feedback 
A) Altering blood flow 
B) Positive feedback only 
C) Negative feedback only 
D) positive and negative feedback

Question 6

Which of the following is a role of thrombin?

Accepted Answer

A) Anticoagulant (protein C activation) 
B) Increases fibrinolysis 
C) Inhibits endothelial cell release of tissue plasminogen activator 
D) Inhibits the formation of fibrin monomers 
A) Anticoagulant (protein C activation) 
B) Increases fibrinolysis 
C) Inhibits endothelial cell release of tissue plasminogen activator 
D) Inhibits the formation of fibrin monomers

Question 7

Which of the following is responsible for urokinase-catalyzed PLG activation?

Accepted Answer

A) ADAMTS-13 
B) LRP 
C) UPAR 
D) EPCR 
A) ADAMTS-13 
B) LRP 
C) UPAR 
D) EPCR

Question 8

All of the following are necessary for a clot to form except:

Accepted Answer

A) Platelets. 
B) Coagulation protein. 
C) Plasmin. 
D) Endothelial cells. 
A) Platelets. 
B) Coagulation protein. 
C) Plasmin. 
D) Endothelial cells.

Question 9

Which of the following is responsible for cleaving ultra-large VWF multimers into functional units?

Accepted Answer

A) LRP 
B) ADAMTS-13 
C) EPCR 
D) UPAR 
A) LRP 
B) ADAMTS-13 
C) EPCR 
D) UPAR

Question 10

Which of the following are involved in "contact activation"?

Accepted Answer

A) Factor XII 
B) Factor XI 
C) PK 
D) All of the above 
A) Factor XII 
B) Factor XI 
C) PK 
D) All of the above

Question 11

Activation of circulating zymogens is achieved through:

Accepted Answer

A) Sympathetic nervous system stimulation. 
B) Endomitosis. 
C) Splenic sequestration. 
D) Proteolytic cleavage. 
A) Sympathetic nervous system stimulation. 
B) Endomitosis. 
C) Splenic sequestration. 
D) Proteolytic cleavage.

Question 12

How do the following systems contribute to coagulation?
A)Complement
B)Fibrinolysis
C)Kinin

Accepted Answer

Complement: Plasmin activates

Question 13

Which plasma PA is unique among the serine proteases because it does not circulate as a zymogen but is fully active toward its substrate plasminogen in a single-chain form?

Accepted Answer

A) uPA 
B) uPAR 
C) PLG 
D) tPA 
A) uPA 
B) uPAR 
C) PLG 
D) tPA

Exam 29: Secondary Hemostasis and Fibrinolysis

What factor does the extrinsic pathway require that the intrinsic and common do not?

Which of the following are formed on a phospholipid surface?

Which of the following is primarily responsible for neutralizing the extrinsic tenase complex?

Thrombin activity impacts coagulation by which of the following mechanism(s)?

Which of the following is a role of thrombin?

Which of the following is responsible for urokinase-catalyzed PLG activation?

All of the following are necessary for a clot to form except:

Which of the following is responsible for cleaving ultra-large VWF multimers into functional units?

Which of the following are involved in "contact activation"?

Activation of circulating zymogens is achieved through:

How do the following systems contribute to coagulation? A)Complement B)Fibrinolysis C)Kinin

Which plasma PA is unique among the serine proteases because it does not circulate as a zymogen but is fully active toward its substrate plasminogen in a single-chain form?

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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