Question 1

The presence of spherocytes in peripheral circulation indicates which of the following?

Accepted Answer

A) An intracorpuscular membrane defect 
B) An intracorpuscular enzyme defect 
C) An extracorpuscular membrane defect 
D) An extracorpuscular enzyme defect 
A) An intracorpuscular membrane defect 
B) An intracorpuscular enzyme defect 
C) An extracorpuscular membrane defect 
D) An extracorpuscular enzyme defect A

Question 2

The presence of schistocytes in the peripheral blood smear indicate:

Accepted Answer

A) Hemolysis due to extracorpuscular defects. 
B) Hemolysis due to intracorpuscular defects. 
C) Hemolysis due to both extracorpuscular and intracorpuscular defects. 
D) Hemolysis with prominent bone marrow response. 
A) Hemolysis due to extracorpuscular defects. 
B) Hemolysis due to intracorpuscular defects. 
C) Hemolysis due to both extracorpuscular and intracorpuscular defects. 
D) Hemolysis with prominent bone marrow response. A

Question 3

The presence of blood in the urine indicates:

Accepted Answer

A) Intravascular hemolysis. 
B) Extravascular hemolysis. 
C) Both intravascular and extravascular hemolysis. 
D) It cannot be determined. 
A) Intravascular hemolysis. 
B) Extravascular hemolysis. 
C) Both intravascular and extravascular hemolysis. 
D) It cannot be determined. A

Question 4

Intravascular hemolysis releases this component into the circulation.

Accepted Answer

A) Haptoglobin 
B) Hemoglobin 
C) Bilirubin 
D) Hemopexin 
A) Haptoglobin 
B) Hemoglobin 
C) Bilirubin 
D) Hemopexin

Question 5

Which results will help to differentiate between intravascular and extravascular hemolysis.

Accepted Answer

A) Low hemoglobin in extravascular; normal hemoglobin in intravascular 
B) Low unconjugated bilirubin in extravascular; high unconjugated bilirubin in intravascular 
C) Presence of splenomegaly in intravascular; absence of splenomegaly in extravascular 
D) Normal haptoglobin in extravascular; low haptoglobin in intravascular 
A) Low hemoglobin in extravascular; normal hemoglobin in intravascular 
B) Low unconjugated bilirubin in extravascular; high unconjugated bilirubin in intravascular 
C) Presence of splenomegaly in intravascular; absence of splenomegaly in extravascular 
D) Normal haptoglobin in extravascular; low haptoglobin in intravascular

Question 6

Infections with Plasmodium cause __________ hemolysis.

Accepted Answer

A) Intravascular 
B) Extravascular 
C) Both intravascular and extravascular 
D) It cannot be determined. 
A) Intravascular 
B) Extravascular 
C) Both intravascular and extravascular 
D) It cannot be determined.

Question 7

Free hemoglobin released in intravascular hemolysis is bound to this protein and transported to the liver.

Accepted Answer

A) Methemalbumin 
B) Carbon monoxide 
C) Haptoglobin 
D) Hemosiderin 
A) Methemalbumin 
B) Carbon monoxide 
C) Haptoglobin 
D) Hemosiderin

Question 8

Which of the following is associated with intravascular hemolysis and not extravascular hemolysis?

Accepted Answer

A) Hemosiderinuria 
B) Increased bilirubin 
C) Reticulocytosis 
D) Polychromasia on the blood smear 
A) Hemosiderinuria 
B) Increased bilirubin 
C) Reticulocytosis 
D) Polychromasia on the blood smear

Question 9

Explain how the tests below differ for acute hemolytic anemia and compensated hemolytic anemia.
A)PB smear
B)Hemoglobin
C)Bone changes

Accepted Answer

a.PB smear: acute: schistocytes and sphe

Question 10

Which of the following test results may help differentiate between intravascular hemolysis and extravascular hemolysis in the body?

Accepted Answer

A) Hemoglobin 
B) Unconjugated bilirubin 
C) Splenomegaly 
D) Haptoglobin 
A) Hemoglobin 
B) Unconjugated bilirubin 
C) Splenomegaly 
D) Haptoglobin

Question 11

This test result is helpful in assessing erythropoietic activity in the bone marrow in response to hemolysis in the peripheral blood.

Accepted Answer

A) Myeloid-to-erythroid relation 
B) Plasma iron-to-erythroid iron index 
C) Reticulocyte production index 
D) MCV 
A) Myeloid-to-erythroid relation 
B) Plasma iron-to-erythroid iron index 
C) Reticulocyte production index 
D) MCV

Question 12

All of the following support the diagnosis of hemolytic anemia except:

Accepted Answer

A) Low haptoglobin. 
B) Low hemoglobin. 
C) Reticulocyte count of 1%. 
D) Bilirubin above 2.5 mg/dL. 
A) Low haptoglobin. 
B) Low hemoglobin. 
C) Reticulocyte count of 1%. 
D) Bilirubin above 2.5 mg/dL.

Question 13

Prosthetic heart valves can lead to an ________ form of hemolysis in which the predominating cell seen is a __________.

Accepted Answer

A) Inherited; schistocyte 
B) Acquired; schistocyte 
C) Inherited; spherocyte 
D) Acquired; polychromasia 
A) Inherited; schistocyte 
B) Acquired; schistocyte 
C) Inherited; spherocyte 
D) Acquired; polychromasia

Question 14

Which of the following test results indicates that there is significant bone marrow turnover in response to hemolysis?

Accepted Answer

A) Thrombocytosis 
B) Low RBC count 
C) High IRF 
D) Elevated bilirubin 
A) Thrombocytosis 
B) Low RBC count 
C) High IRF 
D) Elevated bilirubin

Question 15

Extravascular hemolysis due to a high degree of ineffective erythropoiesis is associated with:

Accepted Answer

A) Cytoplasmic maturation defects. 
B) Autoimmune hemolytic anemia. 
C) Physical trauma to the erythrocyte. 
D) Snake venoms. 
A) Cytoplasmic maturation defects. 
B) Autoimmune hemolytic anemia. 
C) Physical trauma to the erythrocyte. 
D) Snake venoms.

Question 16

What limits the degree of increased erythropoiesis in the bone marrow in the presence of hemolytic anemia?

Accepted Answer

A) Amount of B₁₂ and folate stores 
B) Amount of iron that can be mobilized 
C) Quantity of stem cells in the BM 
D) Degree of extramedullary erythropoiesis 
A) Amount of B₁₂ and folate stores 
B) Amount of iron that can be mobilized 
C) Quantity of stem cells in the BM 
D) Degree of extramedullary erythropoiesis

Question 17

In severe intravascular hemolysis, synthesis of this protein may not be sufficient to what is being used to transport hemoglobin to the liver.

Accepted Answer

A) Bilirubin 
B) Haptoglobin 
C) Albumin 
D) Methemoglobin 
A) Bilirubin 
B) Haptoglobin 
C) Albumin 
D) Methemoglobin

Question 18

A patient's laboratory tests show an increased LDH, a decreased haptoglobin, schistocytes, spherocytes, and polychromasia on the peripheral blood smear.Physical exam revealed splenomegaly.Excessive destruction of erythrocytes may be occurring in the:

Accepted Answer

A) Blood vessels. 
B) Spleen. 
C) Marrow. 
D) Lymph nodes. 
A) Blood vessels. 
B) Spleen. 
C) Marrow. 
D) Lymph nodes.

Question 19

A laboratory professional is reviewing blood smears, and notices moderate spherocytes on one patient.What appropriate follow-up test would help determine the etiology of these cells?

Accepted Answer

A) MCV 
B) Hemoglobin electrophoresis 
C) Direct antiglobulin test 
D) Unconjugated bilirubin 
A) MCV 
B) Hemoglobin electrophoresis 
C) Direct antiglobulin test 
D) Unconjugated bilirubin

Question 20

A condition in which the rate of hemolysis equals the rate of bone marrow erythrocyte production is called:

Accepted Answer

A) Intrinsic hemolytic anemia. 
B) Compensated hemolytic anemia. 
C) Extrinsic hemolytic anemia. 
D) Extravascular hemolysis. 
A) Intrinsic hemolytic anemia. 
B) Compensated hemolytic anemia. 
C) Extrinsic hemolytic anemia. 
D) Extravascular hemolysis.

Exam 13: Introduction to Hemolytic Anemia

The presence of spherocytes in peripheral circulation indicates which of the following?

The presence of schistocytes in the peripheral blood smear indicate:

The presence of blood in the urine indicates:

Intravascular hemolysis releases this component into the circulation.

Which results will help to differentiate between intravascular and extravascular hemolysis.

Infections with Plasmodium cause __________ hemolysis.

Free hemoglobin released in intravascular hemolysis is bound to this protein and transported to the liver.

Which of the following is associated with intravascular hemolysis and not extravascular hemolysis?

Explain how the tests below differ for acute hemolytic anemia and compensated hemolytic anemia. A)PB smear B)Hemoglobin C)Bone changes

Which of the following test results may help differentiate between intravascular hemolysis and extravascular hemolysis in the body?

This test result is helpful in assessing erythropoietic activity in the bone marrow in response to hemolysis in the peripheral blood.

All of the following support the diagnosis of hemolytic anemia except:

Prosthetic heart valves can lead to an ________ form of hemolysis in which the predominating cell seen is a __________.

Which of the following test results indicates that there is significant bone marrow turnover in response to hemolysis?

Extravascular hemolysis due to a high degree of ineffective erythropoiesis is associated with:

What limits the degree of increased erythropoiesis in the bone marrow in the presence of hemolytic anemia?

In severe intravascular hemolysis, synthesis of this protein may not be sufficient to what is being used to transport hemoglobin to the liver.

A patient's laboratory tests show an increased LDH, a decreased haptoglobin, schistocytes, spherocytes, and polychromasia on the peripheral blood smear.Physical exam revealed splenomegaly.Excessive destruction of erythrocytes may be occurring in the:

A laboratory professional is reviewing blood smears, and notices moderate spherocytes on one patient.What appropriate follow-up test would help determine the etiology of these cells?

A condition in which the rate of hemolysis equals the rate of bone marrow erythrocyte production is called:

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

Filters

Prosthetic heart valves can lead to an form of hemolysis in which the predominating cell seen is a __.