Question 1

All of the following can cause a leukocytosis except:

Accepted Answer

A) Malignancy. 
B) Viral infection. 
C) Exposure to radiation. 
D) Immune responses. 
A) Malignancy. 
B) Viral infection. 
C) Exposure to radiation. 
D) Immune responses.

Question 2

Absolute cell count calculation adjusts for what variation(s)?

Accepted Answer

A) Total WBC count 
B) Differential count 
C) Total WBC and differential counts 
D) Total lymphocyte counts 
A) Total WBC count 
B) Differential count 
C) Total WBC and differential counts 
D) Total lymphocyte counts

Question 3

Compare and contrast the five isotypes of immunoglobulins.Include structure, function, and leukocyte interaction in your answer.

Accepted Answer

IgG: monomer with two heavy and two ligh

Question 4

Which cell line matures and differentiates upon exposure to antigen?

Accepted Answer

A) Neutrophilic 
B) Basophilic 
C) Monocytic 
D) Lymphocytic 
A) Neutrophilic 
B) Basophilic 
C) Monocytic 
D) Lymphocytic

Question 5

Reactive lymphocytes differ from normal lymphocytes in that the reactive form:

Accepted Answer

A) Is larger with an increase in basophilic cytoplasm, vacuoles and scalloped cell shape. 
B) Has a condensed nuclear pattern with light pink cytoplasm. 
C) Has many granules, deep basophilic cytoplasm and blast-like nucleus. 
D) Has a condensed nuclear chromatin, eccentric nucleus and deep blue cytoplasm. 
A) Is larger with an increase in basophilic cytoplasm, vacuoles and scalloped cell shape. 
B) Has a condensed nuclear pattern with light pink cytoplasm. 
C) Has many granules, deep basophilic cytoplasm and blast-like nucleus. 
D) Has a condensed nuclear chromatin, eccentric nucleus and deep blue cytoplasm.

Question 6

An instrument printout shows a normal WBC count with a lymphocyte count of 30%.What can be concluded from this?

Accepted Answer

A) The patient is suffering from an infection. 
B) There is a normal lymphocyte concentration. 
C) The patient is an infant. 
D) The patient has leukemia. 
A) The patient is suffering from an infection. 
B) There is a normal lymphocyte concentration. 
C) The patient is an infant. 
D) The patient has leukemia.

Question 7

Which of the following states are associated with an increased leukocyte concentration?

Accepted Answer

A) Birth, pregnancy, infection 
B) Older adults and at birth 
C) Older adults and pregnancy 
D) Tissue necrosis and whole body irradiation 
A) Birth, pregnancy, infection 
B) Older adults and at birth 
C) Older adults and pregnancy 
D) Tissue necrosis and whole body irradiation

Question 8

The identity of immunoglobulins is determined by:

Accepted Answer

A) The number of B cells containing the antibody. 
B) The complexity of the antibody. 
C) The isotype of the heavy chain. 
D) The specificity of the variable region. 
A) The number of B cells containing the antibody. 
B) The complexity of the antibody. 
C) The isotype of the heavy chain. 
D) The specificity of the variable region.

Question 9

A patient with infectious mononucleosis would most likely produce which of the following?

Accepted Answer

A) IgD antibodies 
B) Polyclonal antibodies 
C) Monoclonal antibodies 
D) IgE antibodies 
A) IgD antibodies 
B) Polyclonal antibodies 
C) Monoclonal antibodies 
D) IgE antibodies

Question 10

What is the difference between polyclonal antibodies and monoclonal antibodies? List examples of disorders that generate each type of antibody in your answer.

Accepted Answer

Polyclonal antibodies are a group of het

Question 11

Natural killer cells recognize and kill antigens with attached IgG.This mechanism is described as:

Accepted Answer

A) Phagocytosis. 
B) Cyanosis. 
C) Antibody-dependent cellular activity. 
D) Innate immune response. 
A) Phagocytosis. 
B) Cyanosis. 
C) Antibody-dependent cellular activity. 
D) Innate immune response.

Question 12

The induction of activation-dependent adhesion events depends on adhesion molecules and their ligands located on the leukocyte and what other cell?

Accepted Answer

A) Vascular endothelium cell 
B) Adipocyte 
C) Macrophage 
D) Hepatocyte 
A) Vascular endothelium cell 
B) Adipocyte 
C) Macrophage 
D) Hepatocyte

Question 13

The life span of the neutrophil is spent in three compartments.Which compartment is the primary site of host defense?

Accepted Answer

A) Bone marrow 
B) Liver 
C) Thymus 
D) Tissues 
A) Bone marrow 
B) Liver 
C) Thymus 
D) Tissues

Question 14

A blood sample from a 5-month-old infant indicates a WBC count of 12.5 x 109/L with 65% lymphocytes.What can you conclude from this?

Accepted Answer

A) The infant is normal. 
B) The infant has an infection, as indicated by the elevated WBC count. 
C) The infant has a malignancy in the lymphocyte lineage. 
D) There is not enough information to draw accurate conclusions. 
A) The infant is normal. 
B) The infant has an infection, as indicated by the elevated WBC count. 
C) The infant has a malignancy in the lymphocyte lineage. 
D) There is not enough information to draw accurate conclusions.

Question 15

A name for a plasma cell containing Russell bodies is:

Accepted Answer

A) Plasma cell. 
B) Flame cell. 
C) Mott cell. 
D) Dutcher body. 
A) Plasma cell. 
B) Flame cell. 
C) Mott cell. 
D) Dutcher body.

Question 16

Which cell line does NOT have a large reserve pool in the marrow?

Accepted Answer

A) Granulocytic 
B) Eosinophilic 
C) Monocytic 
D) Lymphocytic 
A) Granulocytic 
B) Eosinophilic 
C) Monocytic 
D) Lymphocytic

Question 17

Which cell line is the first line of defense against helminth infections?

Accepted Answer

A) Neutrophil 
B) Lymphocyte 
C) Monocyte 
D) Eosinophil 
A) Neutrophil 
B) Lymphocyte 
C) Monocyte 
D) Eosinophil

Exam 7: The Leukocyte

All of the following can cause a leukocytosis except:

Absolute cell count calculation adjusts for what variation(s)?

Compare and contrast the five isotypes of immunoglobulins.Include structure, function, and leukocyte interaction in your answer.

Which cell line matures and differentiates upon exposure to antigen?

Reactive lymphocytes differ from normal lymphocytes in that the reactive form:

An instrument printout shows a normal WBC count with a lymphocyte count of 30%.What can be concluded from this?

Which of the following states are associated with an increased leukocyte concentration?

The identity of immunoglobulins is determined by:

A patient with infectious mononucleosis would most likely produce which of the following?

What is the difference between polyclonal antibodies and monoclonal antibodies? List examples of disorders that generate each type of antibody in your answer.

Natural killer cells recognize and kill antigens with attached IgG.This mechanism is described as:

The induction of activation-dependent adhesion events depends on adhesion molecules and their ligands located on the leukocyte and what other cell?

The life span of the neutrophil is spent in three compartments.Which compartment is the primary site of host defense?

A blood sample from a 5-month-old infant indicates a WBC count of 12.5 x 109/L with 65% lymphocytes.What can you conclude from this?

A name for a plasma cell containing Russell bodies is:

Which cell line does NOT have a large reserve pool in the marrow?

Which cell line is the first line of defense against helminth infections?

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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