Question 1

Which of the following best describes the role of "platelet factor 4"?

Accepted Answer

A) Stimulates platelet aggregation 
B) Contributes to fibrin formation 
C) Neutralizes heparin 
D) Mitogenic factor 
A) Stimulates platelet aggregation 
B) Contributes to fibrin formation 
C) Neutralizes heparin 
D) Mitogenic factor

Question 2

Platelet adhesion to collagen and the initiation of platelet aggregation are part of:

Accepted Answer

A) Primary hemostasis. 
B) Secondary hemostasis. 
C) Blood coagulation inhibition. 
D) Fibrinolysis. 
A) Primary hemostasis. 
B) Secondary hemostasis. 
C) Blood coagulation inhibition. 
D) Fibrinolysis.

Question 3

Which of the following substances endogenous to the dense bodies is responsible for continuous platelet activation of surrounding platelets?

Accepted Answer

A) Platelet factor 4 
B) Collagen 
C) ADP 
D) Epinephrine 
A) Platelet factor 4 
B) Collagen 
C) ADP 
D) Epinephrine

Question 4

Which of the following layers of blood vessels is responsible for secretion of procoagulant proteins to maintain tissue repair?

Accepted Answer

A) Tunica adventitia 
B) Tunica intima 
C) Tunica media 
D) All of the above 
A) Tunica adventitia 
B) Tunica intima 
C) Tunica media 
D) All of the above

Question 5

Explain the biochemistry involved in platelet function.

Accepted Answer

-Platelets become activated as a result

Question 6

Which of the following acts as a transport portal for granules to move from the organelle zone to the membrane zone?

Accepted Answer

A) Open canalicular system 
B) Dense tubular system 
C) Membrane glycoproteins 
D) Endoplasmic reticulum 
A) Open canalicular system 
B) Dense tubular system 
C) Membrane glycoproteins 
D) Endoplasmic reticulum

Question 7

Transient cessation of blood loss is achieved through which of the following?

Accepted Answer

A) Formation of secondary hemostatic plug 
B) Fibrinolysis of established thrombus 
C) Formation of primary platelet plug 
D) Inhibition of thrombus formation 
A) Formation of secondary hemostatic plug 
B) Fibrinolysis of established thrombus 
C) Formation of primary platelet plug 
D) Inhibition of thrombus formation

Question 8

All of the following are associated with shape change in platelet activation except:

Accepted Answer

A) Actin and myosin convert to a parallel arrangement from a random arrangement. 
B) The platelet converts to a spiked sphere appearance from a flattened disc appearance. 
C) Tubulin forms a circumferential band around the organelle zone and contracts. 
D) Organelles sequester granule contents. 
A) Actin and myosin convert to a parallel arrangement from a random arrangement. 
B) The platelet converts to a spiked sphere appearance from a flattened disc appearance. 
C) Tubulin forms a circumferential band around the organelle zone and contracts. 
D) Organelles sequester granule contents.

Question 9

Which of the following is a role of the platelets in secondary hemostasis?

Accepted Answer

A) To provide factors needed for serine protease activation 
B) To initiate cross-linking of the fibrin monomers 
C) To activate thrombin 
D) To initiate contact activation 
A) To provide factors needed for serine protease activation 
B) To initiate cross-linking of the fibrin monomers 
C) To activate thrombin 
D) To initiate contact activation

Question 10

During what stage of megakaryocyte development are the platelets released into the circulation?

Accepted Answer

A) Between stages III and IV 
B) At the end of stage II 
C) During the cycling phase 
D) At the point of proplatelet formation. 
A) Between stages III and IV 
B) At the end of stage II 
C) During the cycling phase 
D) At the point of proplatelet formation.

Question 11

After a blood vessel injury, hemostasis is initiated by which of the following?

Accepted Answer

A) Endothelial communication 
B) Platelet function inhibition 
C) Vasoconstriction 
D) Vasodilation 
A) Endothelial communication 
B) Platelet function inhibition 
C) Vasoconstriction 
D) Vasodilation

Question 12

Which of the following substances functions to stabilize platelet aggregates in the platelet plug?

Accepted Answer

A) PDGF 
B) Thrombospondin 
C) Factor V receptor 
D) PF4 
A) PDGF 
B) Thrombospondin 
C) Factor V receptor 
D) PF4

Question 13

Which function of the endothelial cell keeps cells and macromolecules in vessels, and allows nutrient and gas exchange?

Accepted Answer

A) Processing of blood-borne antigens 
B) Production of tissue factor 
C) Production of nitric oxide 
D) Selective blood/tissue barrier 
A) Processing of blood-borne antigens 
B) Production of tissue factor 
C) Production of nitric oxide 
D) Selective blood/tissue barrier

Question 14

What is the first step in coagulation that occurs after vascular trauma?

Accepted Answer

A) Vasoconstriction at the site of injury 
B) Platelet adhesion to collagen 
C) Platelet activation and shape change 
D) Platelet aggregation to more platelets 
A) Vasoconstriction at the site of injury 
B) Platelet adhesion to collagen 
C) Platelet activation and shape change 
D) Platelet aggregation to more platelets

Exam 28: Primary Hemostasis

Which of the following best describes the role of "platelet factor 4"?

Platelet adhesion to collagen and the initiation of platelet aggregation are part of:

Which of the following substances endogenous to the dense bodies is responsible for continuous platelet activation of surrounding platelets?

Which of the following layers of blood vessels is responsible for secretion of procoagulant proteins to maintain tissue repair?

Explain the biochemistry involved in platelet function.

Which of the following acts as a transport portal for granules to move from the organelle zone to the membrane zone?

Transient cessation of blood loss is achieved through which of the following?

All of the following are associated with shape change in platelet activation except:

Which of the following is a role of the platelets in secondary hemostasis?

During what stage of megakaryocyte development are the platelets released into the circulation?

After a blood vessel injury, hemostasis is initiated by which of the following?

Which of the following substances functions to stabilize platelet aggregates in the platelet plug?

Which function of the endothelial cell keeps cells and macromolecules in vessels, and allows nutrient and gas exchange?

What is the first step in coagulation that occurs after vascular trauma?

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

Filters