Question 1

Explain how EPO regulates RBC production.

Accepted Answer

Erythropoiesis is governed by a negative

Question 2

Which major integral protein is used in the mechanism to transport the chloride-bicarbonate exchange?

Accepted Answer

A) Glucose transporter 
B) Anion exchange protein 
C) Ankyrin 
D) Adducing 
A) Glucose transporter 
B) Anion exchange protein 
C) Ankyrin 
D) Adducing

Question 3

What analyte may help to differentiate between intravascular and extravascular hemolysis?

Accepted Answer

A) Hemoglobin 
B) Bilirubin 
C) Haptoglobin 
D) Reticulocytes 
A) Hemoglobin 
B) Bilirubin 
C) Haptoglobin 
D) Reticulocytes

Question 4

Increased hemoglobin affinity for oxygen correlates to which of the following?

Accepted Answer

A) An elevated 2,3-BPG 
B) A normal 2,3-BPG 
C) A decreased 2,3-BPG 
D) It cannot be determined. 
A) An elevated 2,3-BPG 
B) A normal 2,3-BPG 
C) A decreased 2,3-BPG 
D) It cannot be determined.

Question 5

Energy metabolism of the erythrocyte is achieved primarily through which of the following?

Accepted Answer

A) Aerobic glycolysis 
B) Anaerobic glycolysis 
C) Asexual replication 
D) Mitosis 
A) Aerobic glycolysis 
B) Anaerobic glycolysis 
C) Asexual replication 
D) Mitosis

Question 6

Which of the following "marks" the RBC as senescent?

Accepted Answer

A) A cluster of band 3 proteins on the RBC membrane 
B) An RBC with denatured hemoglobin on the RBC membrane 
C) An elongated RBC 
D) Hyperphosphorylation of integral proteins 
A) A cluster of band 3 proteins on the RBC membrane 
B) An RBC with denatured hemoglobin on the RBC membrane 
C) An elongated RBC 
D) Hyperphosphorylation of integral proteins

Question 7

What is the primary way in which erythropoietin affects RBC production?

Accepted Answer

A) It expedites the maturation time of RBCs. 
B) It prevents premature apoptosis of RBCs. 
C) It stimulates facilitated incorporation of hemoglobin into RBCs. 
D) It stimulates expulsion of nuclei from nucleated erythrocyte precursors at a quicker rate. 
A) It expedites the maturation time of RBCs. 
B) It prevents premature apoptosis of RBCs. 
C) It stimulates facilitated incorporation of hemoglobin into RBCs. 
D) It stimulates expulsion of nuclei from nucleated erythrocyte precursors at a quicker rate.

Question 8

Where does normal extravascular hemolysis take place?

Accepted Answer

A) Blood vessels and bone marrow 
B) Lymph nodes and spleen 
C) Spleen and liver 
D) Bone marrow and liver 
A) Blood vessels and bone marrow 
B) Lymph nodes and spleen 
C) Spleen and liver 
D) Bone marrow and liver

Question 9

Explain the effect of the following on RBC survival.Explain your answer.
a.An absence of G6PD
b.An absence of PK
c.A defect in spectrin
d.A defect in ankyrin

Accepted Answer

An absence of G6PD: RBC has a shortened

Question 10

What protein is the major membrane attachment point of the latticework that laminates the inner lining of the RBC membrane.?

Accepted Answer

A) Tropomodulin 
B) Troponyosin 
C) Ankycin 
D) Band 3 
A) Tropomodulin 
B) Troponyosin 
C) Ankycin 
D) Band 3

Question 11

Choose the correct order of normoblastic maturation from least mature to most mature.

Accepted Answer

A) Erythrocyte, reticulocyte, polychromatophilic normoblast, orthochromatic normoblast, basophilic normoblast, pronormoblast 
B) Pronormoblast, basophilic normoblast, polychromatophilic normoblast, orthochromatic normoblast, reticulocyte, erythrocyte 
C) Basophilic normoblast, pronormoblast, polychromatophilic normoblast, orthochromatic normoblast, erythrocyte 
D) pronormoblast, polychromatophilic normoblast, orthochromatic normoblast, reticulocyte, erythrocyte 
A) Erythrocyte, reticulocyte, polychromatophilic normoblast, orthochromatic normoblast, basophilic normoblast, pronormoblast 
B) Pronormoblast, basophilic normoblast, polychromatophilic normoblast, orthochromatic normoblast, reticulocyte, erythrocyte 
C) Basophilic normoblast, pronormoblast, polychromatophilic normoblast, orthochromatic normoblast, erythrocyte 
D) pronormoblast, polychromatophilic normoblast, orthochromatic normoblast, reticulocyte, erythrocyte

Question 12

Which of the following best correlates with an increased reticulocyte count?

Accepted Answer

A) An increased bilirubin 
B) The presence of schistocytes in the peripheral blood smear 
C) Increased polychromasia on the peripheral blood smear 
D) Anisocytosis and poikilocytosis 
A) An increased bilirubin 
B) The presence of schistocytes in the peripheral blood smear 
C) Increased polychromasia on the peripheral blood smear 
D) Anisocytosis and poikilocytosis

Question 13

What growth factor influences the production of the erythrocyte?

Accepted Answer

A) Transforming growth factor-β 
B) Interferon-γ 
C) Erythropoietin 
D) CFU-E 
A) Transforming growth factor-β 
B) Interferon-γ 
C) Erythropoietin 
D) CFU-E

Exam 5: The Erythrocyte

Explain how EPO regulates RBC production.

Which major integral protein is used in the mechanism to transport the chloride-bicarbonate exchange?

What analyte may help to differentiate between intravascular and extravascular hemolysis?

Increased hemoglobin affinity for oxygen correlates to which of the following?

Energy metabolism of the erythrocyte is achieved primarily through which of the following?

Which of the following "marks" the RBC as senescent?

What is the primary way in which erythropoietin affects RBC production?

Where does normal extravascular hemolysis take place?

Explain the effect of the following on RBC survival.Explain your answer. a.An absence of G6PD b.An absence of PK c.A defect in spectrin d.A defect in ankyrin

What protein is the major membrane attachment point of the latticework that laminates the inner lining of the RBC membrane.?

Choose the correct order of normoblastic maturation from least mature to most mature.

Which of the following best correlates with an increased reticulocyte count?

What growth factor influences the production of the erythrocyte?

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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