Exam 22: Myelodysplastic Syndromes

Explain the pathophysiology of MDS.

Explain the relationship between myelodysplastic syndromes and acute leukemia.

Give at least five morphologic indicators of dyserythropoiesis.

Myelodysplastic syndromes are sometimes called "pre-leukemias" because:

What is the major criterion for the diagnosis of acute leukemia?

A bone marrow specimen is received in the cytogenetics lab.FISH analysis has been ordered.The technologist performs the assay and notices that 96% of the patient cells contain both 5q- and 12q- deletions.These cytogenetic findings are characteristic of:

Which of the following tests would help differentiate between MDS/MPD disorders and CML?

All of the following are considered morphologic evidence of dyserythropoiesis except:

Patients with a low percentage of cells that express CD11b, and this marker have a shorter survival compared to patients whose cells do not have these characteristics?

Which of the following laboratory tests would not be helpful in identifying MDS/MPD-u?

A technologist is reviewing a blood smear, and finds a rare blast.Bone marrow analysis also shows dysplasia in 30% of the erythroblasts and myeloid precursors and 4% blasts.What is a possible diagnosis based on these findings?

A 58-year-old male visits his physician for extreme fatigue.After conducting a standard investigation, the physician strongly suspects that his patient is suffering from CML.Which one of the following lab results would confirm this picture?

What must be seen in the bone marrow to confirm refractory anemia with ringed sideroblasts?