Question 1

What red cell morphology marks most types of thalassemia?

Accepted Answer

A) Target cells 
B) Basophilic stippling 
C) Polychromasia 
D) Normal findings 
A) Target cells 
B) Basophilic stippling 
C) Polychromasia 
D) Normal findings

Question 2

Which of the following disorders is characterized by an absence of beta and delta chain production and compensated for by increased gamma chain production?

Accepted Answer

A) Hemoglobin Lepore 
B) Alpha thal major 
C) Hydrops fetalis 
D) HPFH 
A) Hemoglobin Lepore 
B) Alpha thal major 
C) Hydrops fetalis 
D) HPFH

Question 3

List the predominating hemoglobins in each of the following disorders:
A)Hgb H disease
B)Alpha thal minor
C)Beta thal major
D)Beta thal intermedia

Accepted Answer

a.Hgb H disease: Hb H in adults; 25% Hb

Question 4

A promoter mutation of a globin chain gene in thalassemia has this effect on the globin chain:

Accepted Answer

A) Amino acid change. 
B) Longer globin chain. 
C) Shorter globin chain. 
D) Reduced or absent production. 
A) Amino acid change. 
B) Longer globin chain. 
C) Shorter globin chain. 
D) Reduced or absent production.

Question 5

Impaired alpha chain production in alpha thalassemias causes:

Accepted Answer

A) Overproduction of hemoglobin F and A2. 
B) Production of Hb Bart's and Hb H. 
C) Normal hemoglobin distribution. 
D) Fusion of alpha and gamma chains. 
A) Overproduction of hemoglobin F and A2. 
B) Production of Hb Bart's and Hb H. 
C) Normal hemoglobin distribution. 
D) Fusion of alpha and gamma chains.

Question 6

All of the following morphology are typically seen in beta thalassemia patients except:

Accepted Answer

A) Codocytes. 
B) Polychromasia. 
C) Microcytes. 
D) Drepanocytes. 
A) Codocytes. 
B) Polychromasia. 
C) Microcytes. 
D) Drepanocytes.

Question 7

Which of the following statements is true regarding hemoglobinopathies but false in thalassemia?

Accepted Answer

A) Abnormal hemoglobin will polymerize inside erythrocytes, altering red cell shape. 
B) Novel hemoglobins composed of abnormal combinations of normal globin chains can be detected on hemoglobin electrophoresis. 
C) Elevations in embryonic and fetal hemoglobins can be observed. 
D) The amino acid sequence of the globin chains of the abnormal hemoglobins is normal. 
A) Abnormal hemoglobin will polymerize inside erythrocytes, altering red cell shape. 
B) Novel hemoglobins composed of abnormal combinations of normal globin chains can be detected on hemoglobin electrophoresis. 
C) Elevations in embryonic and fetal hemoglobins can be observed. 
D) The amino acid sequence of the globin chains of the abnormal hemoglobins is normal.

Question 8

When a diagnosis of thalassemia is suspected, this test should always be done.

Accepted Answer

A) Hemoglobin electrophoresis 
B) Bone marrow aspiration 
C) Iron studies 
D) Vitamin B₁₂ assay 
A) Hemoglobin electrophoresis 
B) Bone marrow aspiration 
C) Iron studies 
D) Vitamin B₁₂ assay

Question 9

Choose the thalassemia with the best prognosis from the choices below.

Accepted Answer

A) Hgb H disease 
B) Silent carrier alpha thal 
C) Beta thal minor 
D) Beta thal intermedia 
A) Hgb H disease 
B) Silent carrier alpha thal 
C) Beta thal minor 
D) Beta thal intermedia

Question 10

Thalassemias are defined as:

Accepted Answer

A) Qualitative defects in globin chain synthesis. 
B) Quantitative defects in globin chain synthesis. 
C) Kinetic defects of iron in heme synthesis. 
D) Structural defects in heme synthesis. 
A) Qualitative defects in globin chain synthesis. 
B) Quantitative defects in globin chain synthesis. 
C) Kinetic defects of iron in heme synthesis. 
D) Structural defects in heme synthesis.

Question 11

What is the typical electrophoresis pattern in each of the disorders below?
A)Alpha thal minor
B)Hgb H disease
C)Beta thal major
D)Beta thal minor

Accepted Answer

a.Alpha thal minor: Hgb Bart's at birth;

Question 12

Alpha thalassemia major results from deletion in _____ alleles of the alpha chain gene.

Accepted Answer

A) 1 
B) 2 
C) 3 
D) 4 
A) 1 
B) 2 
C) 3 
D) 4

Exam 11: Thalassemia

What red cell morphology marks most types of thalassemia?

Which of the following disorders is characterized by an absence of beta and delta chain production and compensated for by increased gamma chain production?

List the predominating hemoglobins in each of the following disorders: A)Hgb H disease B)Alpha thal minor C)Beta thal major D)Beta thal intermedia

A promoter mutation of a globin chain gene in thalassemia has this effect on the globin chain:

Impaired alpha chain production in alpha thalassemias causes:

All of the following morphology are typically seen in beta thalassemia patients except:

Which of the following statements is true regarding hemoglobinopathies but false in thalassemia?

When a diagnosis of thalassemia is suspected, this test should always be done.

Choose the thalassemia with the best prognosis from the choices below.

Thalassemias are defined as:

What is the typical electrophoresis pattern in each of the disorders below? A)Alpha thal minor B)Hgb H disease C)Beta thal major D)Beta thal minor

Alpha thalassemia major results from deletion in _____ alleles of the alpha chain gene.

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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