Exam 32: Thrombophilia

A patient being treated with heparin therapy has a 65% decrease in platelet count from the baseline count after 6 days of being on the anticoagulant.What is the probable cause of the decrease?

Which of the following alterations would most likely be associated with a hypercoagulable state?

What are the physiological processes involved in hypercoagulability?

Explain why many patients with an inherited thrombophilia are misdiagnosed.

A postop heart transplant patient has been given unfractionated heparin.Five days postop, he develops petechiae, and needs multiple dressing changes over his wound site.What tests should be used to assess the patient's clinical status?

A patient is admitted to the local hospital with a pulmonary embolus.He was initially admitted to the Emergency Department unconscious.Ultrasound revealed a large clot in the patient's saphenous vein.Thrombolytic therapy is administered, and eventually the patient's condition stabilizes.Laboratory tests are performed upon hospital admission, and are seen below: PT: 15.5 sec INR: 2.85 APTT: 76 sec Protein C antigen: 14% Protein C functional activity: 18% Molecular studies: FV-R506Q present Based on this information, what is the most probable diagnosis for this patient?

Which of the following is thought to be a traditional risk factor associated with the formation of arterial thrombi?

Which of the following conditions is NOT associated with an increased tendency for thrombosis?

A tendency to favor thrombus formation that is produced from an imbalance in the major constituents of the hemostatic system is defined as:

Mutations in which of the following gene(s) lead to hyperhomocysteinemia?

Which of the following test results would help differentiate between type I and II protein C deficiencies?

A patient has been evaluated for a coagulopathy, and has been given Coumadin as a mode of treatment.What screening test(s) should be performed to monitor this treatment, and what effect will this therapy have on the coagulation pathway?

Why are thrombolytic agents not recommended for prolonged anticoagulation therapy?

Patients with protein C and/or S deficiencies are at risk for which type of complication?

A 30-year-old patient is diagnosed with a DVT.This is his third episode of DVTs.He is currently hospitalized and receiving heparin therapy.The physician orders a thrombotic risk battery of tests.What is the most appropriate action that the laboratory professional should take?