Question 1

What is the difference between the HSC and the cancer stem cell?

Accepted Answer

The cancer stem cell has unlim

Question 2

How are the FAB and WHO classifications different with respect to acute leukemias?

Accepted Answer

A) FAB classifies acute leukemias by lineage morphology, whereas WHO classifies acute leukemias by immunophenotyping. 
B) FAB classifies acute leukemias by their precursor conditions, whereas WHO classifies acute leukemias by DNA profiling. 
C) Acute leukemia is classified by FAB as having greater than 30% blasts, whereas WHO classifies acute leukemia as having greater than 20% blasts. 
D) Both a and c 
A) FAB classifies acute leukemias by lineage morphology, whereas WHO classifies acute leukemias by immunophenotyping. 
B) FAB classifies acute leukemias by their precursor conditions, whereas WHO classifies acute leukemias by DNA profiling. 
C) Acute leukemia is classified by FAB as having greater than 30% blasts, whereas WHO classifies acute leukemia as having greater than 20% blasts. 
D) Both a and c

Question 3

In what age group does chronic leukemia usually occur?

Accepted Answer

A) All ages 
B) Children 
C) Adults 
D) 15-20 years of age 
A) All ages 
B) Children 
C) Adults 
D) 15-20 years of age

Question 4

Which of the following combinations leads to tumor formation?

Accepted Answer

A) Activation of oncogenes and suppression of proto-oncogenes 
B) Activation of proto-oncogenes with concurrent suppression of oncogenes 
C) Activation of oncogenes and suppression of tumor suppressor genes 
D) Activation of tumor suppressor genes and suppression of proto-oncogenes 
A) Activation of oncogenes and suppression of proto-oncogenes 
B) Activation of proto-oncogenes with concurrent suppression of oncogenes 
C) Activation of oncogenes and suppression of tumor suppressor genes 
D) Activation of tumor suppressor genes and suppression of proto-oncogenes

Question 5

Which of the following is a complication of leukemia treatment?

Accepted Answer

A) Increased uric acid levels 
B) Graft-versus-host disease 
C) DIC 
D) All of the above 
A) Increased uric acid levels 
B) Graft-versus-host disease 
C) DIC 
D) All of the above

Question 6

Somatic cell chromosome mutations resulting in hematologic neoplasms are associated with:

Accepted Answer

A) Chemicals, drugs, bacterial infection. 
B) Drugs, chemicals, renal disease. 
C) Therapeutic radiation, drugs and chemicals. 
D) Viral and bacterial infections, autoantibodies. 
A) Chemicals, drugs, bacterial infection. 
B) Drugs, chemicals, renal disease. 
C) Therapeutic radiation, drugs and chemicals. 
D) Viral and bacterial infections, autoantibodies.

Question 7

Which of the following disorders is characterized by signs of dyshematopoiesis?

Accepted Answer

A) Acute leukemias 
B) Chronic leukemias 
C) Myelodysplastic syndromes 
D) Myeloproliferative disorders 
A) Acute leukemias 
B) Chronic leukemias 
C) Myelodysplastic syndromes 
D) Myeloproliferative disorders

Question 8

TSG, or tumor suppressor gene, plays a role in neoplastic transformation of cells by what mechanism?

Accepted Answer

A) Suppressing the cellular proliferation and neoplastic transformation 
B) Initiating the cellular proliferation 
C) Triggering the proto-oncogenes to activate to oncogenes 
D) Initiating ttranslocation of genes 
A) Suppressing the cellular proliferation and neoplastic transformation 
B) Initiating the cellular proliferation 
C) Triggering the proto-oncogenes to activate to oncogenes 
D) Initiating ttranslocation of genes

Question 9

Which progenitor cells normally do not have the capacity for self-renewal?

Accepted Answer

A) CMP and CLP 
B) HSC 
C) Somatic cells 
D) Primitive hematopoietic precursor cells 
A) CMP and CLP 
B) HSC 
C) Somatic cells 
D) Primitive hematopoietic precursor cells

Question 10

An abundance of blasts and some mature forms with an apparent decrease in the intermediate maturational stages is referred to as:

Accepted Answer

A) Acute lymphoid leukemia. 
B) Chronic myelogenous leukemia. 
C) Chronic lymphocytic leukemia. 
D) Leukemic hiatus. 
A) Acute lymphoid leukemia. 
B) Chronic myelogenous leukemia. 
C) Chronic lymphocytic leukemia. 
D) Leukemic hiatus.

Question 11

Name the two main classification systems that identify the following leukemias.Indicate how they are different.
A)MDS
B)Acute leukemias

Accepted Answer

Each can be classified by WHO

Question 12

What is the purpose of the induction phase in chemotherapy?

Accepted Answer

A) To eradicate normal cells 
B) To eradicate tumor cells 
C) To initiate an immune response against tumors 
D) To help the patient tolerate the tumor 
A) To eradicate normal cells 
B) To eradicate tumor cells 
C) To initiate an immune response against tumors 
D) To help the patient tolerate the tumor

Question 13

Acute leukemias are classified as:

Accepted Answer

A) Benign neoplasms. 
B) Malignant neoplasms. 
C) Neoplasms. 
D) Benign tumors. 
A) Benign neoplasms. 
B) Malignant neoplasms. 
C) Neoplasms. 
D) Benign tumors.

Question 14

Which disease state has Auer bodies present on examination of the blood smear?

Accepted Answer

A) MDS 
B) MPD 
C) MDS/MPD 
D) AML 
A) MDS 
B) MPD 
C) MDS/MPD 
D) AML

Exam 20: Introduction to Hematopoietic Neoplasms

What is the difference between the HSC and the cancer stem cell?

How are the FAB and WHO classifications different with respect to acute leukemias?

In what age group does chronic leukemia usually occur?

Which of the following combinations leads to tumor formation?

Which of the following is a complication of leukemia treatment?

Somatic cell chromosome mutations resulting in hematologic neoplasms are associated with:

Which of the following disorders is characterized by signs of dyshematopoiesis?

TSG, or tumor suppressor gene, plays a role in neoplastic transformation of cells by what mechanism?

Which progenitor cells normally do not have the capacity for self-renewal?

An abundance of blasts and some mature forms with an apparent decrease in the intermediate maturational stages is referred to as:

Name the two main classification systems that identify the following leukemias.Indicate how they are different. A)MDS B)Acute leukemias

What is the purpose of the induction phase in chemotherapy?

Acute leukemias are classified as:

Which disease state has Auer bodies present on examination of the blood smear?

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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