Question 1

The type of anemia commonly associated with HUS is:

Accepted Answer

A) Microcytic, hypochromic. 
B) Macrocytic, normochromic. 
C) Normocytic, normochromic. 
D) Microcytic, normochromic. 
A) Microcytic, hypochromic. 
B) Macrocytic, normochromic. 
C) Normocytic, normochromic. 
D) Microcytic, normochromic.

Question 2

Which of the following analytes would be decreased in HUS?

Accepted Answer

A) Bilirubin 
B) Lactate dehydrogenase 
C) Haptoglobin 
D) BUN 
A) Bilirubin 
B) Lactate dehydrogenase 
C) Haptoglobin 
D) BUN

Question 3

Which of the following mechanisms is thought to cause exercise-induced hemoglobinuria?

Accepted Answer

A) Erythrocyte membrane protein changes 
B) Oxidative stress and erythrocyte age 
C) Excessive thermal buildup and damage to membranes 
D) Foot strike damage 
A) Erythrocyte membrane protein changes 
B) Oxidative stress and erythrocyte age 
C) Excessive thermal buildup and damage to membranes 
D) Foot strike damage

Question 4

A 7-year-old girl is brought to a physician due to a swollen hand with an ischemic lesion.The physician suspects a brown recluse spider bite.What is the suspected mechanism of erythrocyte damage caused by venom of this spider?

Accepted Answer

A) Changes in glycophorin on the erythrocyte membrane 
B) DIC 
C) Lysis caused by passage through the fibrin clot 
D) Changes in the permeability of the cell membrane 
A) Changes in glycophorin on the erythrocyte membrane 
B) DIC 
C) Lysis caused by passage through the fibrin clot 
D) Changes in the permeability of the cell membrane

Question 5

Which of the following results would typically be found in HUS?

$\begin{array}{ll}
{\text { PT }} & \text { PTT } \
  \hline\text { a. Prolonged } & \text { prolonged } \
\text { b. Normal } & \text { prolonged } \
\text { c. Prolonged } & \text { prolonged } \
\text { d. Normal } & \text { normal }
\end{array}$

Accepted Answer

Hemolytic Uremic Syndrome (HUS) is a con

Question 6

Which of the following analytes would be increased in MAHA?

Accepted Answer

A) BUN 
B) Haptoglobin 
C) Creatinine 
D) Bilirubin 
A) BUN 
B) Haptoglobin 
C) Creatinine 
D) Bilirubin

Question 7

A 20 year old disoriented female is brought to the hospital with a fever of 102°F.Results of the CBC demonstrate a platelet count of 68 x 109/L, a hemoglobin of 9.0 gm/dl, WBC count of 22x 109/L and the presence of polychromasia and schistocytes on the peripheral blood smear.Her husband indicated she had no recent episodes of diarrhea but had been taking penicillin for an ongoing infection.The most likely diagnosis for the patient is:

Accepted Answer

A) TTP 
B) D-HUS 
C) DIC 
D) HELLP syndrome 
A) TTP 
B) D-HUS 
C) DIC 
D) HELLP syndrome

Question 8

The underlying cause of TTP is:

Accepted Answer

A) An unregulated coagulation cascade. 
B) Deficiency in vWF multimers. 
C) Deficiency of ADAMTS13 protease. 
D) Overproduction of cryoprecipitate. 
A) An unregulated coagulation cascade. 
B) Deficiency in vWF multimers. 
C) Deficiency of ADAMTS13 protease. 
D) Overproduction of cryoprecipitate.

Question 9

A woman visits her obstetrician for a routine prenatal visit at 24 weeks.Her blood pressure is 180/100 and her urinalysis shows 3+ protein.The peripheral blood smear demonstrated the presence of schistocytes.What other elevated test results might be found?

Accepted Answer

A) Liver enzymes 
B) BUN and creatinine 
C) PT and APTT 
D) Haptoglobin 
A) Liver enzymes 
B) BUN and creatinine 
C) PT and APTT 
D) Haptoglobin

Question 10

Which of the following findings on the peripheral blood smear are typically associated with DIC?

Accepted Answer

A) Target cells 
B) Schistocytes and thrombocytopenia 
C) Helmet cells 
D) Spherocytes and polychromasia 
A) Target cells 
B) Schistocytes and thrombocytopenia 
C) Helmet cells 
D) Spherocytes and polychromasia

Question 11

Which of the following laboratory findings are similar in both HUS and TTP?

Accepted Answer

A) Increased reticulocytes; thrombocytopenia; decrease in haptoglobin 
B) Decreased reticulocytes; decrease in haptoglobin and thrombocytopenia 
C) Increased total and unconjugated serum bilirubin, and increase in haptoglobin 
D) Decreased total and unconjugated serum bilirubin, and decreased haptoglobin 
A) Increased reticulocytes; thrombocytopenia; decrease in haptoglobin 
B) Decreased reticulocytes; decrease in haptoglobin and thrombocytopenia 
C) Increased total and unconjugated serum bilirubin, and increase in haptoglobin 
D) Decreased total and unconjugated serum bilirubin, and decreased haptoglobin

Question 12

A runner is in training for the Chicago Marathon.After his most recent 26 mile run, he notices that his urine is reddish-brown.By the next morning his urine is clear and yellow but he decides to see his primary care physician.All of the hematology and chemistry results are within the reference range.What is the most likely reason for this scenario?

Accepted Answer

A) Initial dark color was due to dehydration. 
B) This is exercise induced hemoglobinuria. 
C) There were uric acid crystals precipitated in the initial urine. 
D) There is insufficient information to determine the reason. 
A) Initial dark color was due to dehydration. 
B) This is exercise induced hemoglobinuria. 
C) There were uric acid crystals precipitated in the initial urine. 
D) There is insufficient information to determine the reason.

Exam 17: Hemolytic Anemia: Nonimmune Defects

The type of anemia commonly associated with HUS is:

Which of the following analytes would be decreased in HUS?

Which of the following mechanisms is thought to cause exercise-induced hemoglobinuria?

A 7-year-old girl is brought to a physician due to a swollen hand with an ischemic lesion.The physician suspects a brown recluse spider bite.What is the suspected mechanism of erythrocyte damage caused by venom of this spider?

Which of the following results would typically be found in HUS? PT PTT a. Prolonged prolonged b. Normal prolonged c. Prolonged prolonged d. Normal normal

Which of the following analytes would be increased in MAHA?

The underlying cause of TTP is:

A woman visits her obstetrician for a routine prenatal visit at 24 weeks.Her blood pressure is 180/100 and her urinalysis shows 3+ protein.The peripheral blood smear demonstrated the presence of schistocytes.What other elevated test results might be found?

Which of the following findings on the peripheral blood smear are typically associated with DIC?

Which of the following laboratory findings are similar in both HUS and TTP?

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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