Question 1

How is globin chain production regulated in the body?

Accepted Answer

A) By regulating the amount of heme produced 
B) By regulating the amount of iron incorporated into the heme moiety 
C) By regulating the number of RBCs produced 
D) By regulating the rate of transcription for protein synthesis 
A) By regulating the amount of heme produced 
B) By regulating the amount of iron incorporated into the heme moiety 
C) By regulating the number of RBCs produced 
D) By regulating the rate of transcription for protein synthesis

Question 2

Which of the following abnormal hemoglobins is formed when iron is in the ferric state?

Accepted Answer

A) Oxyhemoglobin 
B) Carboxyhemoglobin 
C) Methemoglobin 
D) Sulfhemoglobin 
A) Oxyhemoglobin 
B) Carboxyhemoglobin 
C) Methemoglobin 
D) Sulfhemoglobin

Question 3

Oxyhemoglobin is in the _______ configuration.This is achieved by the _______ of 2, 3 DPG.

Accepted Answer

A) Tense; presence 
B) Tense; absence 
C) Relaxed; presence 
D) Relaxed; absence 
A) Tense; presence 
B) Tense; absence 
C) Relaxed; presence 
D) Relaxed; absence

Question 4

Produce an oxygen dissociation curve that would reflect the following conditions and give an example of a condition that would cause these shifts.
A)A shift to the left
B)A shift to the right

Accepted Answer

A)Left shi

Question 5

What conditions may be caused by acquired nonfunctional hemoglobins?

Accepted Answer

A) Hypoxia and iron in ferric state 
B) Sulfhemoglobin production 
C) Hypoxia and cyanosis 
D) Decrease in deoxyhemoglobin 
A) Hypoxia and iron in ferric state 
B) Sulfhemoglobin production 
C) Hypoxia and cyanosis 
D) Decrease in deoxyhemoglobin

Question 6

Which of the following conditions will produce a favorable environment for hemoglobin to bind to oxygen? (Normal body temperature is <100°F; normal blood pH: 7.35-7.45.)

Accepted Answer

A) A body temperature of 102°F 
B) A high 2,3-BPG concentration 
C) A blood pH of 7.31 
D) High PO₂ 
A) A body temperature of 102°F 
B) A high 2,3-BPG concentration 
C) A blood pH of 7.31 
D) High PO₂

Question 7

Choose the hemoglobin that has the highest oxygen affinity.

Accepted Answer

A) Hb A 
B) Hb F 
C) Methemoglobin 
D) Sulfhemoglobin 
A) Hb A 
B) Hb F 
C) Methemoglobin 
D) Sulfhemoglobin

Question 8

What structure within hemoglobin identifies the type of hemoglobin?

Accepted Answer

A) Tetrameric molecule 
B) Globin chains 
C) Heme group 
D) Salt bonds 
A) Tetrameric molecule 
B) Globin chains 
C) Heme group 
D) Salt bonds

Question 9

A shift to the left is caused by which of the following? (normal blood pH: 7.35-7.45)

Accepted Answer

A) A blood pH of 7.54 
B) A body temperature of 103°F 
C) An increased 2, 3 BPG concentration 
D) An increased PCO₂ 
A) A blood pH of 7.54 
B) A body temperature of 103°F 
C) An increased 2, 3 BPG concentration 
D) An increased PCO₂

Question 10

To regulate the amount of heme produced, what enzyme must be regulated?

Accepted Answer

A) ALAS2 
B) PBG deaminase 
C) Uroporphyrinogen III 
D) Ferrochelatase 
A) ALAS2 
B) PBG deaminase 
C) Uroporphyrinogen III 
D) Ferrochelatase

Question 11

A high concentration of H+ ions will have what kind of effect on the oxygen dissociation curve?

Accepted Answer

A) A shift to the left 
B) No effect on the oxygen dissociation curve 
C) A shift to the right 
D) It cannot be determined based on the information given. 
A) A shift to the left 
B) No effect on the oxygen dissociation curve 
C) A shift to the right 
D) It cannot be determined based on the information given.

Question 12

Correlate embryonic/fetal hemoglobin production to stages of fetal hematopoiesis.

Accepted Answer

Fetal hematopoiesis:
Embryonic

Question 13

The majority of carbon dioxide is transported in the body by:

Accepted Answer

A) Dissolving in plasma. 
B) As carbonic acid. 
C) Binding to hemoglobin. 
D) Methemoglobin 
A) Dissolving in plasma. 
B) As carbonic acid. 
C) Binding to hemoglobin. 
D) Methemoglobin

Question 14

In the complete hemoglobin structure, where is iron located?

Accepted Answer

A) Attached to the alpha-globin chains 
B) Attached to the non alpha-globin chain 
C) In the mitochondria 
D) In the protoporphyrin ring 
A) Attached to the alpha-globin chains 
B) Attached to the non alpha-globin chain 
C) In the mitochondria 
D) In the protoporphyrin ring

Question 15

How can you detect methemoglobin in the laboratory?

Accepted Answer

A) By spectral analysis at 541 nm 
B) By spectral analysis at 630 nm 
C) By hemoglobin quantitation using acid elution techniques 
D) By looking at the patient's blood color-it will be blue. 
A) By spectral analysis at 541 nm 
B) By spectral analysis at 630 nm 
C) By hemoglobin quantitation using acid elution techniques 
D) By looking at the patient's blood color-it will be blue.

Exam 6: Hemoglobin

How is globin chain production regulated in the body?

Which of the following abnormal hemoglobins is formed when iron is in the ferric state?

Oxyhemoglobin is in the _______ configuration.This is achieved by the _______ of 2, 3 DPG.

Produce an oxygen dissociation curve that would reflect the following conditions and give an example of a condition that would cause these shifts. A)A shift to the left B)A shift to the right

What conditions may be caused by acquired nonfunctional hemoglobins?

Which of the following conditions will produce a favorable environment for hemoglobin to bind to oxygen? (Normal body temperature is <100°F; normal blood pH: 7.35-7.45.)

Choose the hemoglobin that has the highest oxygen affinity.

What structure within hemoglobin identifies the type of hemoglobin?

A shift to the left is caused by which of the following? (normal blood pH: 7.35-7.45)

To regulate the amount of heme produced, what enzyme must be regulated?

A high concentration of H+ ions will have what kind of effect on the oxygen dissociation curve?

Correlate embryonic/fetal hemoglobin production to stages of fetal hematopoiesis.

The majority of carbon dioxide is transported in the body by:

In the complete hemoglobin structure, where is iron located?

How can you detect methemoglobin in the laboratory?

Introduction

Cellular Homeostasis

Hematopoiesis

Structure and Function of Hematopoietic Organs

The Erythrocyte

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

Filters

Oxyhemoglobin is in the _ configuration.This is achieved by the _ of 2, 3 DPG.