Question 1

Which of the following lineages are derived from the bipotential progenitor cell CFU-EMk?

Accepted Answer

A) Erythrocytes and megakaryocytes 
B) Eosinophils and megakaryocytes 
C) Erythrocytes and monocytes 
D) Eosinophils and monocytes 
A) Erythrocytes and megakaryocytes 
B) Eosinophils and megakaryocytes 
C) Erythrocytes and monocytes 
D) Eosinophils and monocytes

Question 2

All of the following are hematopoietic growth factor receptor subgroups except:

Accepted Answer

A) Unique ligand-specific alpha chains, with shared beta chains. 
B) Unique ligand-specific alpha chains that share GP130. 
C) Unique ligand-specific alpha chains, with shared gamma chains. 
D) Unique ligand-specific alpha chains, with shared zeta chains. 
A) Unique ligand-specific alpha chains, with shared beta chains. 
B) Unique ligand-specific alpha chains that share GP130. 
C) Unique ligand-specific alpha chains, with shared gamma chains. 
D) Unique ligand-specific alpha chains, with shared zeta chains.

Question 3

GM-CSF is considered a(n):

Accepted Answer

A) Early-acting cytokine. 
B) Late-acting cytokine. 
C) Lineage-specific cytokine. 
D) Early-acting and multilineage cytokine. 
A) Early-acting cytokine. 
B) Late-acting cytokine. 
C) Lineage-specific cytokine. 
D) Early-acting and multilineage cytokine.

Question 4

All of the following are negative regulators of hematopoiesis except:

Accepted Answer

A) TGFβ. 
B) TNF. 
C) Kit ligand. 
D) MIP1$\alpha$ 
A) TGFβ. 
B) TNF. 
C) Kit ligand. 
D) MIP1$\alpha$

Question 5

Which lineage promotes differentiation and maturation primarily with the use of interleukins?

Accepted Answer

A) Monocytes 
B) Erythrocytes 
C) Platelets 
D) Lymphocytes 
A) Monocytes 
B) Erythrocytes 
C) Platelets 
D) Lymphocytes

Question 6

What property primarily determines the specific targets of hematopoietic growth factors?

Accepted Answer

A) Unique transcription factors in the target cells 
B) Unique signaling pathways in the target cells 
C) Unique receptors in the membranes of the target cells 
D) Lack of inhibitors to the growth factor in question 
A) Unique transcription factors in the target cells 
B) Unique signaling pathways in the target cells 
C) Unique receptors in the membranes of the target cells 
D) Lack of inhibitors to the growth factor in question

Question 7

Which of the following gives rise to the lymphoid and myeloid cells?

Accepted Answer

A) Committed lymphoid progenitor cell 
B) Multipotential progenitor cell 
C) Committed myeloid progenitor cell 
D) CFU-GEMM 
A) Committed lymphoid progenitor cell 
B) Multipotential progenitor cell 
C) Committed myeloid progenitor cell 
D) CFU-GEMM

Question 8

Which term is used to describe when two cells from the same precursor take a separate route of development?

Accepted Answer

A) Maturation 
B) Differentiation 
C) Commitment 
D) Specialization 
A) Maturation 
B) Differentiation 
C) Commitment 
D) Specialization

Question 9

Several cytokines are used for clinical purposes.Which three cell lines are primarily increased by the injection of EPO, TPO, and CFU-GM?

Accepted Answer

A) Lymphocytes, monocytes, and platelets 
B) Erythrocytes, platelets, and granulocytes 
C) Monocytes, platelets, and stem cells 
D) Stem cells, precursor cells, and maturing cells 
A) Lymphocytes, monocytes, and platelets 
B) Erythrocytes, platelets, and granulocytes 
C) Monocytes, platelets, and stem cells 
D) Stem cells, precursor cells, and maturing cells

Question 10

Cytokine receptors that lack an intrinsic kinase domain transmit signals primarily through:

Accepted Answer

A) Transmembrane protein activation. 
B) Activation of cytoplasmic kinases. 
C) Heterodimer integral protein activation. 
D) None of the above. 
A) Transmembrane protein activation. 
B) Activation of cytoplasmic kinases. 
C) Heterodimer integral protein activation. 
D) None of the above.

Question 11

Which term is used to describe all cells antecedent to mature cells of a particular lineage?

Accepted Answer

A) Progenitor cells 
B) Stem cells 
C) Precursor cells 
D) Maturing cells 
A) Progenitor cells 
B) Stem cells 
C) Precursor cells 
D) Maturing cells

Question 12

Stem cells and progenitor cells can be measured by clonal assays in vitro.How are maturing cells measured?

Accepted Answer

A) Clonal assays 
B) Phenotyping 
C) Flow cytometry 
D) Morphologic analysis 
A) Clonal assays 
B) Phenotyping 
C) Flow cytometry 
D) Morphologic analysis

Question 13

Explain how hematopoiesis employs autocrine, paracrine, and juxtacrine signaling.Provide examples of each.

Accepted Answer

Autocrine signaling: produced by and act

Question 14

All of the following are characteristics of an optimal hematopoietic environment except:

Accepted Answer

A) Fibronectin. 
B) Extracellular matrix. 
C) Stromal cells. 
D) Synthetic cytokines. 
A) Fibronectin. 
B) Extracellular matrix. 
C) Stromal cells. 
D) Synthetic cytokines.

Question 15

Compare and contrast the HSC and the progenitor cells.How are they similar? How are they different?

Accepted Answer

The hematopoietic stem cell HSC) has cap

Exam 3: Hematopoiesis

Which of the following lineages are derived from the bipotential progenitor cell CFU-EMk?

All of the following are hematopoietic growth factor receptor subgroups except:

GM-CSF is considered a(n):

All of the following are negative regulators of hematopoiesis except:

Which lineage promotes differentiation and maturation primarily with the use of interleukins?

What property primarily determines the specific targets of hematopoietic growth factors?

Which of the following gives rise to the lymphoid and myeloid cells?

Which term is used to describe when two cells from the same precursor take a separate route of development?

Several cytokines are used for clinical purposes.Which three cell lines are primarily increased by the injection of EPO, TPO, and CFU-GM?

Cytokine receptors that lack an intrinsic kinase domain transmit signals primarily through:

Which term is used to describe all cells antecedent to mature cells of a particular lineage?

Stem cells and progenitor cells can be measured by clonal assays in vitro.How are maturing cells measured?

Explain how hematopoiesis employs autocrine, paracrine, and juxtacrine signaling.Provide examples of each.

All of the following are characteristics of an optimal hematopoietic environment except:

Compare and contrast the HSC and the progenitor cells.How are they similar? How are they different?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

The Leukocyte

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopaties: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Introduction to Hemolytic Anemia

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Granulocyte and Monocyte Disorders

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Disorders

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Acute Lymphoblastic Leukemias

Lymphoid Malignancies: Chronic Lymphoid Leukemias, Lymphomas, and Plasma Cell Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hematology Procedures and Hemostasis

Bone Marrow Examination

Automation in Hematology and Hemostasis

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Laboratory Testing in Coagulation

Quality Assessment in the Hematology Laboratory

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