Exam 21: Genomes and Their Evolution

Barbara McClintock,who achieved fame for discovering that genes could move within genomes,had her meticulous work ignored for nearly four decades,but eventually won the Nobel Prize.Why was her work so distrusted?

Researchers at the University of British Columbia are working on a way to analyze gene expression within a single cell as it differentiates.This is significant because

Approximately how many bacterial genomes are in the process of being sequenced?

Human and chimpanzee share most of their nucleotide sequence yet exhibit significant phenotypic differences.What is likely to be the most important sequence differences between these two species?

What is metagenomics?

A multigene family is composed of

What characteristic of short tandem repeat DNA makes it useful for studying evolution?

What is proteomics?

A recent report has indicated several conclusions about comparisons of our genome with that of Neanderthals.This report concludes,in part,that,at some period in evolutionary history,there was a mixture of the two genomes.This is evidenced by

Bioinformatics includes all of the following except

Use the following figure to answer the next few questions. This figure shows a diagram of blocks of genes on human chromosome 16 and the locations of blocks of similar genes on four chromosomes of the mouse. -How might identical and obviously duplicated gene sequences have gotten from one chromosome to another?

Studies in knockout mice have demonstrated an important role of the FOXP2 transcription factor in the development of vocalizations.Recent sequence comparisons of the FOXP2 gene in Neanderthals and modern humans show that while the DNA sequence may be different,the protein sequence it codes for is identical.What might be logically inferred from this information?

Homeotic genes

Which of the following can be duplicated in a genome?

Use the following information to answer the questions below. You have isolated a gene sequence from the mustard plant Arabidopsis and have BLAST searched the NCBI database.Your sequence hit several EST sequences that were identified as transcription factors.These sequences were found in E.coli,Chlamydomonas (a green algae),yeast,mice,and humans and only had a few base pair differences. -What can be surmised about your transcription factor?

After finding a new medicinal plant,a pharmaceutical company decides to determine if the plant has genes similar to those of other known medicinal plants by annotating the genome of the new plant.Why does the company do this?

One of the characteristics of retrotransposons is that

Which of the following most correctly describes a shotgun technique for sequencing a genome?

In order to determine the probable function of a particular sequence of DNA in humans,what might be the most reasonable approach?

In comparing the genomes of humans and those of other higher primates,it is seen that humans have a large metacentric pair we call chromosome 2 among our 46 chromosomes,whereas the other primates of this group have 48 chromosomes and any pair like the human chromosome 2 pair is not present; instead,the primate groups each have two pairs of midsize acrocentric chromosomes.What is the most likely explanation?