Exam 15: Gene Mutation and Molecular Medicine

Electrophoresis separates DNA fragments of different sizes, but this technique does not indicate which of the fragments contains the DNA piece of interest. This problem is solved by

Phenylketonuria is an example of a genetic disease in which

"Mad cow disease" is most likely due to

In multicellular organisms

Knowledge of genes and the proteins they make is being used to design new drug treatments for genetic diseases. This new field is called _______.

Phenylketonuria

In gel electrophoresis of DNA fragments,

Since the 1990s, researchers have isolated a mutated gene and then characterized the protein. Because this process is opposite to the genetic analyses done before the mid-1980s, it is called _______.

Which of the following statements is true regarding short tandem repeats (STRs)?

Many restriction sites are _______; each strand contains the same sequence when read from the 5´ end or the 3´ end.

Fragile-X syndrome

A mutant strain of yeast grew well at 20°, but not at 37°C, whereas the wild-type strain grew well at both temperatures. The mutation is an example of a

Mutational "hot spots" in human DNA

Which of the following mutations would probably be the most deleterious?

People with PKU often have too much of the amino acid _______ and too little of the amino acid _______.

Restriction enzymes

Which of the following statements about prion diseases is true?

Most diseases that are genetic are _______; that is, they are caused by the interactions of many genes as well as by environmental factors.

A common method for sorting DNA by size is _______.

Benzopyrene, a component of cigarette smoke, can induce DNA mutations by