Question 1

In multicellular organisms,gene _________ is critical for directing development and maintaining homeostasis.

Accepted Answer

A) expression 
B) duplication 
C) deletion 
D) regulation 
A) expression 
B) duplication 
C) deletion 
D) regulation

Question 2

Small RNAs,once thought to be of no importance in gene expression contain

Accepted Answer

A) between 21 to 28 nucleotides. 
B) exactly 64 nucleotides. 
C) between 15 and 20 codons. 
D) between 21 and 64 codons. 
A) between 21 to 28 nucleotides. 
B) exactly 64 nucleotides. 
C) between 15 and 20 codons. 
D) between 21 and 64 codons.

Question 3

All of the following are examples of shapes in regulatory proteins which are used to bind to DNA except the

Accepted Answer

A) zinc finger. 
B) TATA box. 
C) helix-turn-helix. 
D) homeodomain. 
E) leucine zipper. 
A) zinc finger. 
B) TATA box. 
C) helix-turn-helix. 
D) homeodomain. 
E) leucine zipper.

Question 4

Which of the following must happen for transcription to be initiated?

Accepted Answer

A) DNA polymerase must have access to the DNA double helix and also must be capable of binding to the gene's promoter. 
B) RNA polymerase must have access to the DNA double helix and also must be capable of binding to the gene's promoter. 
C) DNA polymerase must have access to the RNA and also must be capable of binding to the gene's promoter. 
D) DNA ligase must have access to the DNA double helix and also must be capable of binding to the gene's promoter. 
E) DNA kinase must have access to the DNA double helix and also must be capable of binding to the gene's promoter. 
A) DNA polymerase must have access to the DNA double helix and also must be capable of binding to the gene's promoter. 
B) RNA polymerase must have access to the DNA double helix and also must be capable of binding to the gene's promoter. 
C) DNA polymerase must have access to the RNA and also must be capable of binding to the gene's promoter. 
D) DNA ligase must have access to the DNA double helix and also must be capable of binding to the gene's promoter. 
E) DNA kinase must have access to the DNA double helix and also must be capable of binding to the gene's promoter.

Question 5

The enzyme dicer chops dsRNA molecules into small pieces of

Accepted Answer

A) mRNA and miRNA. 
B) miRNA and siRNA. 
C) siRNA and rRNA. 
D) mRNA and siRNA. 
A) mRNA and miRNA. 
B) miRNA and siRNA. 
C) siRNA and rRNA. 
D) mRNA and siRNA.

Question 6

The progesterone receptor (PR)is a steroid hormone receptor and transcription factor.The protein SRC-1,which does not bind DNA by itself,can bind to PR and increase expression of genes regulated by PR.Based on this information,SRC-1 is a(n)

Accepted Answer

A) coactivator. 
B) inducer. 
C) basal transcription factor. 
D) specific transcription factor. 
A) coactivator. 
B) inducer. 
C) basal transcription factor. 
D) specific transcription factor.

Question 7

RNA polymerase binds to a site on DNA called the

Accepted Answer

A) operator. 
B) repressor. 
C) footprint. 
D) promoter. 
E) operon. 
A) operator. 
B) repressor. 
C) footprint. 
D) promoter. 
E) operon.

Question 8

DNA methylation,adding a methyl group to DNA nucleotides,in vertebrates ensures that

Accepted Answer

A) the gene functions without interruption. 
B) no errors will be made during transcription. 
C) the nucleosome will quickly form,which assists in mRNA formation. 
D) once that gene is transcribed,the mRNA is saved and used over and over again. 
E) once a gene is turned off,it will remain off. 
A) the gene functions without interruption. 
B) no errors will be made during transcription. 
C) the nucleosome will quickly form,which assists in mRNA formation. 
D) once that gene is transcribed,the mRNA is saved and used over and over again. 
E) once a gene is turned off,it will remain off.

Question 9

A bacterial gene regulatory system is likely to have all of the following except

Accepted Answer

A) a coding sequence. 
B) an operator. 
C) a promoter. 
D) one or more introns. 
E) a ribosome recognition sitE. 
A) a coding sequence. 
B) an operator. 
C) a promoter. 
D) one or more introns. 
E) a ribosome recognition sitE.

Question 10

A site of negative genetic regulation;binding by repressor blocks transcription.

Accepted Answer

A) operon 
B) repressor 
C) promoter 
D) operator 
E) CAP 
A) operon 
B) repressor 
C) promoter 
D) operator 
E) CAP

Question 11

In eukaryotes,specific transcription factors have two distinct domains:

Accepted Answer

A) a DNA-binding domain and a RNA-binding domain. 
B) a DNA-binding domain and an activation domain. 
C) a DNA-binding domain and a repressor domain. 
D) a DNA-binding domain and an enhancer domain. 
E) a DNA-binding domain and an operator domain. 
A) a DNA-binding domain and a RNA-binding domain. 
B) a DNA-binding domain and an activation domain. 
C) a DNA-binding domain and a repressor domain. 
D) a DNA-binding domain and an enhancer domain. 
E) a DNA-binding domain and an operator domain.

Question 12

The basic tool of genetic regulation is the ability of certain proteins to bind to specific

Accepted Answer

A) regulatory RNA sequences. 
B) regulatory DNA sequences. 
C) repressor parts of the gene. 
D) promoter parts of the gene. 
E) enzymes of the cell. 
A) regulatory RNA sequences. 
B) regulatory DNA sequences. 
C) repressor parts of the gene. 
D) promoter parts of the gene. 
E) enzymes of the cell.

Question 13

Production of the iron-storing protein ferritin is regulated by aconitase,which binds to a 30-nucleotide sequence at the beginning of the ferritin mRNA and interferes with ribosome binding.Aconitase is a

Accepted Answer

A) transcription repressor protein. 
B) translation repressor protein. 
C) RNA interference protein. 
D) translation initiation protein. 
A) transcription repressor protein. 
B) translation repressor protein. 
C) RNA interference protein. 
D) translation initiation protein.

Question 14

Which of the following statements regarding control of the lac operon and lactose utilization in bacteria is false?

Accepted Answer

A) The lac operon will not be induced in the presence of both glucose and lactose. 
B) Control of the lac operon is negative,mediated by a repressor. 
C) The lac operon controls the expression of three downstream genes. 
D) Bacteria preferentially utilize lactose as a carbon source. 
A) The lac operon will not be induced in the presence of both glucose and lactose. 
B) Control of the lac operon is negative,mediated by a repressor. 
C) The lac operon controls the expression of three downstream genes. 
D) Bacteria preferentially utilize lactose as a carbon source.

Question 15

A site at the 5' end of a gene to which RNA polymerase attaches to initiate transcription.

Accepted Answer

A) operon 
B) repressor 
C) promoter 
D) operator 
E) CAP 
A) operon 
B) repressor 
C) promoter 
D) operator 
E) CAP

Question 16

Eukaryotic cell mRNA transcripts tend to be very ______ and can remain in the cell for hours.

Accepted Answer

A) stable 
B) long 
C) isolated 
D) analogous 
A) stable 
B) long 
C) isolated 
D) analogous

Question 17

You are performing a mutagenesis screen to isolate mutations in Drosophila.While looking through a batch of mutagenized flies,you find a fly in which its antenna had been transformed to a pair of extra legs.You surmise that this fly must have a mutation in regulatory protein that contains which type of DNA-binding motif?

Accepted Answer

A) helix-turn-helix 
B) homeodomain 
C) zinc finger 
D) leucine zipper 
A) helix-turn-helix 
B) homeodomain 
C) zinc finger 
D) leucine zipper

Question 18

The gene encoding apolipoprotein B exists in two isoforms,APOB100 and APOB48.These two forms are produced as a result of

Accepted Answer

A) tissue-specific expression. 
B) a gene mutation that results in a stop codon. 
C) RNA editing. 
D) alternative splicing. 
A) tissue-specific expression. 
B) a gene mutation that results in a stop codon. 
C) RNA editing. 
D) alternative splicing.

Question 19

A protein that regulates transcription by binding to the operator.

Accepted Answer

A) operon 
B) repressor 
C) promoter 
D) operator 
E) CAP 
A) operon 
B) repressor 
C) promoter 
D) operator 
E) CAP

Question 20

Vertebrate cells apparently possess a protein that by binding to clusters of 5-methylcytosine ensures that the bound gene will stay in the "off" position.This control on the role of gene regulation is a result of

Accepted Answer

A) translation. 
B) enhancer expression. 
C) methylation. 
D) promotor expression. 
E) operator suppression. 
A) translation. 
B) enhancer expression. 
C) methylation. 
D) promotor expression. 
E) operator suppression.

Exam 16: Control of Gene Expression

In multicellular organisms,gene _________ is critical for directing development and maintaining homeostasis.

Small RNAs,once thought to be of no importance in gene expression contain

All of the following are examples of shapes in regulatory proteins which are used to bind to DNA except the

Which of the following must happen for transcription to be initiated?

The enzyme dicer chops dsRNA molecules into small pieces of

The progesterone receptor (PR)is a steroid hormone receptor and transcription factor.The protein SRC-1,which does not bind DNA by itself,can bind to PR and increase expression of genes regulated by PR.Based on this information,SRC-1 is a(n)

RNA polymerase binds to a site on DNA called the

DNA methylation,adding a methyl group to DNA nucleotides,in vertebrates ensures that

A bacterial gene regulatory system is likely to have all of the following except

A site of negative genetic regulation;binding by repressor blocks transcription.

In eukaryotes,specific transcription factors have two distinct domains:

The basic tool of genetic regulation is the ability of certain proteins to bind to specific

Production of the iron-storing protein ferritin is regulated by aconitase,which binds to a 30-nucleotide sequence at the beginning of the ferritin mRNA and interferes with ribosome binding.Aconitase is a

Which of the following statements regarding control of the lac operon and lactose utilization in bacteria is false?

A site at the 5' end of a gene to which RNA polymerase attaches to initiate transcription.

Eukaryotic cell mRNA transcripts tend to be very ______ and can remain in the cell for hours.

The gene encoding apolipoprotein B exists in two isoforms,APOB100 and APOB48.These two forms are produced as a result of

A protein that regulates transcription by binding to the operator.

Vertebrate cells apparently possess a protein that by binding to clusters of 5-methylcytosine ensures that the bound gene will stay in the "off" position.This control on the role of gene regulation is a result of

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