Exam 24: Myeloproliferative Neoplasms

Which of the following test results is most consistent with a diagnosis of PMF?

Which of the following are criteria for systemic mastocytosis?

The myeloproliferative disorder best described by increased leukocytes,immature granulocytes,and decreased LAP with the Philadelphia chromosome present is which of the following?

Which of the following assays differentiate CNL from CML?

A known CML patient's blood is received in the lab for a routine CBC.The laboraty professional counts 55% blasts in the smear.The most likely reason for this occurrence is that the patient is in:

A patient's CBC revealed marked leukocytosis with an increased number of immature granulocytes.A few promyelocytes and blasts were seen.There were also an increased number of eosinophils and basophils with rare immature forms.The hemoglobin and hematocrit were normal,but platelets were slightly decreased.Which disorder is associated with these findings?

Which of the following tests would help differentiate primary polycythemia from secondary polycythemia?

Which of the following would differentiate a myeloproliferative disorder from a myelodysplastic disorder?

Which is a characteristic of ET that would help distinguish it from reactive thrombocytosis?

CML is characterized by which of the following:

The role of PDGF in PMF is to:

A 45-year-old male patient presents to his physician with a palpable spleen.A CBC reveals an absolute eosinophil count of 2.5 × 10⁹/L.After six weeks,the patient's CBC indicates an absolute eosinophil count of 2.9 × 10⁹/L.Which of the following is a likely diagnosis for this patient?

A physician strongly suspects CML in a patient and has already ordered a bone marrow differential and cytogenetic analysis for the Philadelphia chromosome.What other test would help confirm the CML picture for this patient?

The key factor to distinguish relative and absolute polycythemia is that a relative polycythemia is caused by:

What feature distinguishes CML from a leukemoid reaction?

The Philadelphia chromosome results from the fusion of which of the following?

Contrast primary polycythemia and secondary polycythemia based on pathophysiology.

A patient's laboratory results indicate a markedly increased hemoglobin,hematocrit,and red blood cell count.White blood cells and platelets are also slightly increased.The erythropoietin level is decreased.Which is most likely :

A patient presents with a moderate leukoerythroblastic anemia,striking anisocytosis,and poikilocytosis.The anemia is normocytic,normochromic.Large platelets are noted.Dacryocytes,elliptocytes,and ovalocytes are present.Basophilic stippling is present.What disease is associated with these findings?

The characteristic poikilocyte often seen in the peripheral blood of patients with PMF that indicates extramedullary hematopoiesis is: