Exam 41: Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Which of the following represents the location of the chromosomes during metaphase?

The presence of a chimerism after a bone marrow transplant indicates:

FISH is a molecular technique that can provide important clinical information that conventional cytogenetic analysis might not be able to provide.In CML,what can FISH identify that conventional cytogenetics cannot?

The cell cycle contains four phases: G₁,S,G₂,and mitosis.Which phase must be active to study human chromosomes?

Monosomy is an example of:

Acute myeloid leukemia patients have acquired clonal chromosome aberrations in the leukemic blast cells.One cytogenetic aberration is identified as 11q23 abnormality with an MLL gene rearrangement.What is the typical morphologic feature?

List at least five indications for performing FISH analysis in patients suspected of having a hematolymphoid disorder.

The patient who has the most favorable prognosis with acute lymphoblastic leukemia might have hyperdiploid karyotypes with a chromosome count ranging from 54-65 with what concurrence?

A 42-year-old female patient has a solid tumor in her left lung.The physician has ordered cytogenetic analysis.What type of specimen is needed?

Which of the following terms is used to describe a chromosomal aberration present in a human cell that is a multiple of n?

Which of the following chromosomal aberrations is associated with Burkitt lymphoma?

During the harvesting phase of sample preparation,the cells are arrested in metaphase by:

A 60-year-old patient was admitted to the local hospital presenting with petechiae on his upper torso.Physical examination revealed a thin,pale man.Admission labs came back,and the results revealed the presence of 50% blasts and 25% hypergranular promyelocytes.A bone marrow aspirate was ordered that confirmed the peripheral blood picture.Cytogenetic analysis revealed the following: t (11;17) ( q23;q21).How does this impact the patient's care?

Following a successful bone marrow transplant as treatment for a hematopoietic disorder,what is the term used if the recipient's cells have a normal karyotype?

Discuss the impact of FISH technology in hematolymphoid disorders and bone marrow transplant recipients.

A patient is receiving chemotherapy for Hodgkin lymphoma.When the treatment ends,a cytogenetic analysis is ordered to determine whether the treatment was successful.Which of the following would be the most appropriate specimen to collect for this?

The chromosome abnormality type that results in a daughter cell with an extra chromosome-or trisomy-or a daughter cell with a loss of chromosome is characterized as which of the following?

A 3-year-old girl is confirmed to have ALL by immunophenotyping.She is positive for the CALLA antigen.Cytogenetic analysis results indicate the presence of the Philadelphia chromosome.Which of the following applies to her?

Which of the following is an appropriate specimen source for cytogenetic analysis?

A cytogenetic analysis is performed,and the result is inv (7) ( q21q32).Name the structural aberration,and explain how it was formed.