Exam 28: Mature Lymphoid Neoplasms

Which of the following lymphoproliferative disorders is most closely associated with Richter's transformation?

The specimen of choice to confirm a lymphoma is a:

Which of the following agents promotes the development of non-Hodgkin lymphoma through mucosa-associated lymphoid tissue (MALT)infiltration?

Which of the following contributes to the pathogenesis of lymphoid neoplasms?

A male of 65 years of age is seen at a local hospital with symptoms of enlarged lymph nodes and possible gastrointestinal tract problems.The peripheral blood smear revealed cells resembling diffuse large B-cell lymphoma.The FISH studies demonstrated the translocation of BCL-1.What is the probable disease?

Describe the WHO and Ann Arbor classification systems of lymphoid neoplasms.

In the subgroups of chronic leukemic lymphoid malignancies,which are the key features of Sézary syndrome?

A technologist is reviewing a blood smear and notices 35% lymphocytes with azurophilic granules and nuclei with mature clumped chromatin.These cells are typical of those found in:

Which of the following detects clonality in an unknown cell population?

Which of the Hodgkin lymphoma histologic subtypes is composed of numerous reactive small lymphocytes and rare tumor cells that grow in loose nodular aggregates or popcorn cells (i.e. ,L&H cells)?

Explain how ALL and Burkitt-type ALL are different morphologically.

A diagnosis of CLL requires morphologic and phenotypic findings of which of the following?

A 25-year-old male presents with an enlarged lymph node in his axillary region.Further testing confirms malignancy in the enlarged lymph node but nowhere else.In which stage of lymphoma,according to the Ann Arbor classification system,is the patient?

A physician is working up a patient.Based on physical examination,history,and initial screening tests,the physician suspects anaplastic large cell lymphoma (ALCL),but still needs to rule out classical Hodgkin lymophoma (HL).Which of the following test results would confirm ALCL?

Morphological differences between ALL and Burkitt-type ALL include which of the following?

Which test should be included when distinguishing between diffuse large B-cell lymphoma and blastic mantle cell lymphoma?

Explain the molecular and cytogenetic profile of a patient with Burkitt lymphoma.

The presence of which of the following cell types confirms the diagnosis of Hodgkin lymphoma?

Explain how environmental factors contribute to the pathogenesis of lymphoid neoplasms.

A lymph node biopsy from a patient with lymphadenopathy is performed.Which of the following findings would support the diagnosis of a reactive proliferation rather than a malignant lymphoma?