Exam 19: Hemolytic Anemia: Immune Anemias

A patient on α-methyldopa could develop a type of drug-induced immune hemolysis that mimics what condition?

The most likely cause of immediate hemolytic transfusion reaction is from antibodies of which system?

Autoantibodies associated with CAD are directed against which antigen system?

2-14 days after a transfusion,a patient is cross-matched for another transfusion.Slight hemolysis and a positive DAT are found.What testing should follow?

During transfusion,a patient developed pain in the area of the needle,shortness of breath,and chest tightness.What is the most likely cause?

A newborn is left at a hospital emergency department.The baby appears lethargic and slightly jaundiced.Laboratory work on the baby shows a positive DAT with polyspecific AHG and anti-IgG.The hemoglobin is 7.3 gm/dl,and the peripheral blood smear shows marked polychromasia,macrocytosis,and an increased number of nucleated RBCs.The bilirubin is 4.4 mg/dl.What do you suspect is the underlying cause of these results?

Cold hemolytic anemia is usually caused by the presence of an:

Compare the three mechanisms of drug-induced immune hemolysis.

A patient is admitted with chest pain and extreme shortness of breath.Patient history is unremarkable except for ingestion of oral cefoxitin for the past 4 days.A DAT profile is positive with polyspecific AHG,negative with anti-IgG,and positive with anti-C3.The hemoglobin is 8.0 gm/dl.Based on these results,what mechanism of drug-induced hemolysis is present?

Explain why the DAT profile in CAD is reactive only with polyspecific AHG and anti-C3 but not with anti-IgG.

A patient's hemoglobin went from a value of 13.0 gm/dl after transfusion to 10.6 gm/dl 3 days after transfusion.What is the most likely type of transfusion reaction?

A sample demonstrates a DAT profile that is positive with polyspecific AHG,negative with anti-IgG,and positive with anti-C3.If the Donath-Landsteiner test was also positive,what should the clinical laboratory professional do?

ABO incompatibility is associated with which type of transfusion reaction?

Which of the following characterizes acute hemolytic transfusion reaction?

Mixed-type AIHA is typically characterized by autoantibodies of which classes?

Which of the following conditions is not paired with the correct autoantibody?

A 44-year-old female presents for her routine examination.She complains of tiredness and difficulty in breathing when she exerts herself.Her DAT is positive with polyspecific AHG and anti-IgG.Her hemoglobin is 7.5 gm/dl,and her indices suggest a normocytic,normochromic anemia.Her peripheral blood smear shows the presence of spherocytes.What is the most likely diagnosis?

Paroxysmal cold hemoglobinuria is confirmed by a positive:

Which of the following antibody specificities is associated with PCH?

Compare the differences in the activation of complement that can lead to intravascular hemolysis or extravascular hemolysis.