Question 1

Which of the following statements describes the role of transcription factors (TF)in hematopoiesis?

Accepted Answer

A) TF expression does not change during hematopoiesis. 
B) TF function either to activate or suppress target gene expression. 
C) TF block the differentiation pathway for hematopoietic precursors. 
D) TF abnormalities are rarely seen in hematologic malignancies. 
A) TF expression does not change during hematopoiesis. 
B) TF function either to activate or suppress target gene expression. 
C) TF block the differentiation pathway for hematopoietic precursors. 
D) TF abnormalities are rarely seen in hematologic malignancies. B

Question 2

An unknown cell is positive for CD34 and negative for CD38,lineage markers,and HLA-DR.Identify the cell.

Accepted Answer

A) MPP 
B) Hematopoietic stem cell 
C) CLP 
D) CMP 
A) MPP 
B) Hematopoietic stem cell 
C) CLP 
D) CMP B

Question 3

Which components are included in the stromal cell compartment?

Accepted Answer

A) Matrix proteins and regulatory cytokines 
B) Adipocytes,endothelial cells,fibroblasts,T lymphocytes,and macrophages 
C) Stem cells 
D) Progenitor cells 
A) Matrix proteins and regulatory cytokines 
B) Adipocytes,endothelial cells,fibroblasts,T lymphocytes,and macrophages 
C) Stem cells 
D) Progenitor cells B

Question 4

Which lineage promotes differentiation and maturation primarily with the use of interleukins?

Accepted Answer

A) Monocytes 
B) Erythrocytes 
C) Platelets 
D) Lymphocytes 
A) Monocytes 
B) Erythrocytes 
C) Platelets 
D) Lymphocytes

Question 5

What property primarily determines the specific targets of hematopoietic growth factors?

Accepted Answer

A) Unique transcription factors in the target cells 
B) Unique signaling pathways in the target cells 
C) Unique receptors in the membranes of the target cells 
D) Lack of inhibitors to the growth factor in question 
A) Unique transcription factors in the target cells 
B) Unique signaling pathways in the target cells 
C) Unique receptors in the membranes of the target cells 
D) Lack of inhibitors to the growth factor in question

Question 6

Explain how hematopoiesis uses autocrine,paracrine,and juxtacrine signaling.Choose one and provide an example of signaling through that pathway.

Accepted Answer

Autocrine signaling: produced by and act

Question 7

Several cytokines are used for clinical purposes.Which three cell lines are primarily increased by the injection of EPO,TPO,and CFU-GM?

Accepted Answer

A) Lymphocytes,monocytes,and platelets 
B) Erythrocytes,platelets,and granulocytes 
C) Monocytes,platelets,and stem cells 
D) Stem cells,precursor cells,and maturing cells 
A) Lymphocytes,monocytes,and platelets 
B) Erythrocytes,platelets,and granulocytes 
C) Monocytes,platelets,and stem cells 
D) Stem cells,precursor cells,and maturing cells

Question 8

Which of the following is an example of a lineage-specific cytokine?

Accepted Answer

A) Kit ligand 
B) CFU-GEMM 
C) IL-3 
D) G-CSF 
A) Kit ligand 
B) CFU-GEMM 
C) IL-3 
D) G-CSF

Question 9

All of the following are key components of hematopoietic differentiation except:

Accepted Answer

A) The formation of mature blood components with a finite life span 
B) The differentiation of blood components when exposed to different cytokines 
C) The commitment to produce blood cells only 
D) The activation of programmed cell death 
A) The formation of mature blood components with a finite life span 
B) The differentiation of blood components when exposed to different cytokines 
C) The commitment to produce blood cells only 
D) The activation of programmed cell death

Question 10

Explain the role of stromal cells in the hematopoietic microenvironment.

Accepted Answer

Stromal cells express homing receptors f

Question 11

Compare and contrast the HSC and the progenitor cells.How are they similar?
 How are they different?

Accepted Answer

The hematopoietic stem cell (HSC) has ca

Question 12

Which of the following cytokines inhibits stem cell proliferation?

Accepted Answer

A) Interferon 
B) MIP-1α 
C) Lactoferrin 
D) TNF-a 
A) Interferon 
B) MIP-1α 
C) Lactoferrin 
D) TNF-a

Question 13

Which of the following types of cell signaling describes how SCF and Flt3 ligand predominately regulate stem cell homeostasis?

Accepted Answer

A) Autocrine 
B) Paracrine 
C) Juxtacrine 
D) Endocrine 
A) Autocrine 
B) Paracrine 
C) Juxtacrine 
D) Endocrine

Question 14

Which of the following lineages are derived from the bipotential progenitor cell CFU-EMk?

Accepted Answer

A) Erythrocytes and megakaryocytes 
B) Eosinophils and megakaryocytes 
C) Erythrocytes and monocytes 
D) Eosinophils and monocytes 
A) Erythrocytes and megakaryocytes 
B) Eosinophils and megakaryocytes 
C) Erythrocytes and monocytes 
D) Eosinophils and monocytes

Question 15

All of the following are hematopoietic growth factor receptor subgroups except:

Accepted Answer

A) Unique ligand-specific alpha chains with shared beta chains 
B) Unique ligand-specific alpha chains that share GP130 
C) Unique ligand-specific alpha chains with shared gamma chains 
D) Unique ligand-specific alpha chains with shared zeta chains 
A) Unique ligand-specific alpha chains with shared beta chains 
B) Unique ligand-specific alpha chains that share GP130 
C) Unique ligand-specific alpha chains with shared gamma chains 
D) Unique ligand-specific alpha chains with shared zeta chains

Question 16

Explain the JAK-STAT signaling pathway,and describe how it can contribute to disease.

Accepted Answer

JAK: Janus family PTKs (protein tyrosine

Question 17

All of the following are functions of the BM stroma except:

Accepted Answer

A) Adhesion of hematopoietic precursors 
B) Cell-to-cell interaction 
C) Synthesis of cytokines 
D) Incorporation of essential metals into mature cells 
A) Adhesion of hematopoietic precursors 
B) Cell-to-cell interaction 
C) Synthesis of cytokines 
D) Incorporation of essential metals into mature cells

Question 18

Which of the following classes of hematopoietic cells is committed to becoming an erythrocyte?

Accepted Answer

A) Hematopoietic stem cell 
B) Multipotential progenitor cell 
C) Committed lymphoid progenitor 
D) BFU-E 
A) Hematopoietic stem cell 
B) Multipotential progenitor cell 
C) Committed lymphoid progenitor 
D) BFU-E

Question 19

Which of the following molecules (synthetically generated)is administered to patients with renal disease to stimulate red cell production?

Accepted Answer

A) GM-CSF 
B) Interleukin-2 
C) EPO 
D) G-CSF 
A) GM-CSF 
B) Interleukin-2 
C) EPO 
D) G-CSF

Question 20

Which of the following best describes the phenotype of the hematopoietic stem cell?

Accepted Answer

A) CD34+ CD38+Lin-HLA-DR-Rh123Bright,SCF-R+,TPO-R+ 
B) CD34+ CD33+CD38+Lin- Rh123Lo 
C) CD34+ CD38-Lin-HLA-DR-Rh123Lo,SCF-R+,TPO-R+ 
D) CD3+,CD4+,CD5+,CD8+,CD38-,HLA-DR- 
A) CD34+ CD38+Lin-HLA-DR-Rh123Bright,SCF-R+,TPO-R+ 
B) CD34+ CD33+CD38+Lin- Rh123Lo 
C) CD34+ CD38-Lin-HLA-DR-Rh123Lo,SCF-R+,TPO-R+ 
D) CD3+,CD4+,CD5+,CD8+,CD38-,HLA-DR-

Exam 4: Hematopoiesis

Which of the following statements describes the role of transcription factors (TF)in hematopoiesis?

An unknown cell is positive for CD34 and negative for CD38,lineage markers,and HLA-DR.Identify the cell.

Which components are included in the stromal cell compartment?

Which lineage promotes differentiation and maturation primarily with the use of interleukins?

What property primarily determines the specific targets of hematopoietic growth factors?

Explain how hematopoiesis uses autocrine,paracrine,and juxtacrine signaling.Choose one and provide an example of signaling through that pathway.

Several cytokines are used for clinical purposes.Which three cell lines are primarily increased by the injection of EPO,TPO,and CFU-GM?

Which of the following is an example of a lineage-specific cytokine?

All of the following are key components of hematopoietic differentiation except:

Explain the role of stromal cells in the hematopoietic microenvironment.

Compare and contrast the HSC and the progenitor cells.How are they similar? How are they different?

Which of the following cytokines inhibits stem cell proliferation?

Which of the following types of cell signaling describes how SCF and Flt3 ligand predominately regulate stem cell homeostasis?

Which of the following lineages are derived from the bipotential progenitor cell CFU-EMk?

All of the following are hematopoietic growth factor receptor subgroups except:

Explain the JAK-STAT signaling pathway,and describe how it can contribute to disease.

All of the following are functions of the BM stroma except:

Which of the following classes of hematopoietic cells is committed to becoming an erythrocyte?

Which of the following molecules (synthetically generated)is administered to patients with renal disease to stimulate red cell production?

Which of the following best describes the phenotype of the hematopoietic stem cell?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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