Question 1

Name the type of immune response that the granulocytes and monocytes predominately participate in and explain their role in this response.

Accepted Answer

Innate Immune Response (IRR)
This is the body’s first response to pathogens.  Pathogen-associated molecular patterns (PAMP) are recognized by a leukocyte’s surface receptors for PAMP (pattern recognition receptors [PRR]). Once a pathogen has been recognized, neutrophils, monocytes, and macrophages can phagocytose and kill the organism. The innate IR is rapid but limited.

Question 2

List 4 locations of neutrophils and the three sub-locations within the bone marrow.Explain the general purpose of these locations.

Accepted Answer

(1) Bone marrow with (s) mitotic pool, (b) maturation pool, and (c)storage pool).  Cells proliferate and develop into functional cells waiting to be called out to circulation.
(2) Peripheral blood circulating waiting for chemotactic signal
(3) Peripheral blood marginating can easily diapedese
(4) Tissue  phagocytosis

Question 3

Which of the following is associated with an increased leukocyte concentration?

Accepted Answer

A) Birth,pregnancy,infection 
B) Older adults,birth 
C) Older adults,pregnancy 
D) Tissue necrosis,whole body irradiation 
A) Birth,pregnancy,infection 
B) Older adults,birth 
C) Older adults,pregnancy 
D) Tissue necrosis,whole body irradiation A

Question 4

Which cell line does not have a large reserve pool in the marrow?

Accepted Answer

A) Granulocytic 
B) Eosinophilic 
C) Monocytic 
D) Lymphocytic 
A) Granulocytic 
B) Eosinophilic 
C) Monocytic 
D) Lymphocytic

Question 5

What cell lineage is characterized by the presence of CD14 on its surface?

Accepted Answer

A) Neutrophilic 
B) Eosinophilic 
C) Monocytic 
D) Lymphocytic 
A) Neutrophilic 
B) Eosinophilic 
C) Monocytic 
D) Lymphocytic

Question 6

Differentiate between absolute and relative concentrations of specific types of leukocytes and give an example of a condition that typically produces abnormal absolute or relative concentrations.

Accepted Answer

The relative concentration is the percen

Question 7

Which of the following terms is used to describe an absolute increase in the number of eosinophils?

Accepted Answer

A) Neutropenia 
B) Eosinophilia 
C) Leukocytosis 
D) Lymphocytosis 
A) Neutropenia 
B) Eosinophilia 
C) Leukocytosis 
D) Lymphocytosis

Question 8

List and explain the steps that neutrophils take to leave the peripheral blood circulation and lead to the neutrophil kill function.

Accepted Answer

Step 1: Antigen causes the release of ch

Question 9

A(n)__________ has purple-black granules that obscure the cytoplasm,whereas a(n)__________ contains granules that orange to red in color.

Accepted Answer

A) eosinophil;neutrophil 
B) monocyte;lymphocyte 
C) lymphocyte;basophil 
D) basophil;eosinophil 
A) eosinophil;neutrophil 
B) monocyte;lymphocyte 
C) lymphocyte;basophil 
D) basophil;eosinophil

Question 10

Which of the following peripheral blood pictures is likely to be seen if elevated levels of GM-CSF persist in the bone marrow?

Accepted Answer

A) Monocytosis,neutropenia 
B) Neutrophilia,eosinophilia 
C) Monocytopenia,granulocytosis 
D) Granulocytosis,monocytosis 
A) Monocytosis,neutropenia 
B) Neutrophilia,eosinophilia 
C) Monocytopenia,granulocytosis 
D) Granulocytosis,monocytosis

Question 11

Phagocytosis consumes a large amount of energy provided by what process?

Accepted Answer

A) Diapedesis 
B) Erythrophagocytosis 
C) Innate immune response 
D) Aerobic and/or anaerobic glycolysis 
A) Diapedesis 
B) Erythrophagocytosis 
C) Innate immune response 
D) Aerobic and/or anaerobic glycolysis

Question 12

All of the following precursors are found in the mitotic pool except:

Accepted Answer

A) Promyelocyte 
B) Myeloblast 
C) Metamyelocyte 
D) Myelocyte 
A) Promyelocyte 
B) Myeloblast 
C) Metamyelocyte 
D) Myelocyte

Question 13

An instrument printout shows a WBC count of 4.5 × 10⁹/L with 75% neutrophils.What is the absolute neutrophil count?

Accepted Answer

A) 1.9 * 10⁹/L 
B) 3.8 * 10⁹/L 
C) 3.4 *10⁹/L 
D) 4.5 * 10⁹/L 
A) 1.9 * 10⁹/L 
B) 3.8 * 10⁹/L 
C) 3.4 *10⁹/L 
D) 4.5 * 10⁹/L

Question 14

What characteristic that is present in promyelocytes morphologically differentiates a promyelocyte from a myeloblast?

Accepted Answer

A) Primary granules 
B) Secondary granules 
C) Loss of nucleoli 
D) Pink cytoplasm 
A) Primary granules 
B) Secondary granules 
C) Loss of nucleoli 
D) Pink cytoplasm

Question 15

The induction of activation-dependent adhesion events depends on adhesion molecules and their ligands located on the leukocyte and what other cell?

Accepted Answer

A) Vascular endothelium cell 
B) Adipocyte 
C) Macrophage 
D) Hepatocyte 
A) Vascular endothelium cell 
B) Adipocyte 
C) Macrophage 
D) Hepatocyte

Question 16

Absolute cell count calculation adjusts for what variation(s)?

Accepted Answer

A) Total WBC count 
B) Differential count 
C) Total WBC and differential counts 
D) Total lymphocyte counts 
A) Total WBC count 
B) Differential count 
C) Total WBC and differential counts 
D) Total lymphocyte counts

Question 17

Basophils contribute to the induction and maintenance of allergic reactions by interacting with B lymphocytes through which molecule?

Accepted Answer

A) CD34 
B) SCF 
C) CD40L 
D) C5a 
A) CD34 
B) SCF 
C) CD40L 
D) C5a

Question 18

IL-5 is the cytokine that is required for which cell type to proliferate and terminally differentiate?

Accepted Answer

A) Neutrophil 
B) Eosinophil 
C) Basophil 
D) Monocyte 
A) Neutrophil 
B) Eosinophil 
C) Basophil 
D) Monocyte

Question 19

Name the cells of the neutrophil lineage in order from earliest morphologically recognizable cell to most mature cell and include one unique morphologic characteristic of each cell.

Accepted Answer

Myeloblast,promyelocyte,myelocyte,metamy

Question 20

All of the following are included in the kill mechanism by neutrophils except:

Accepted Answer

A) Chemoattraction of neutrophils to infectious agent. 
B) Diapedesis of neutrophils from blood into tissues. 
C) The formation of the phagolysosome by the neutrophil. 
D) The presentation of the infectious agent to a monocyte for phagocytosis. 
A) Chemoattraction of neutrophils to infectious agent. 
B) Diapedesis of neutrophils from blood into tissues. 
C) The formation of the phagolysosome by the neutrophil. 
D) The presentation of the infectious agent to a monocyte for phagocytosis.

Exam 7: Granulocytes and Monocytes

Name the type of immune response that the granulocytes and monocytes predominately participate in and explain their role in this response.

List 4 locations of neutrophils and the three sub-locations within the bone marrow.Explain the general purpose of these locations.

Which of the following is associated with an increased leukocyte concentration?

Which cell line does not have a large reserve pool in the marrow?

What cell lineage is characterized by the presence of CD14 on its surface?

Differentiate between absolute and relative concentrations of specific types of leukocytes and give an example of a condition that typically produces abnormal absolute or relative concentrations.

Which of the following terms is used to describe an absolute increase in the number of eosinophils?

List and explain the steps that neutrophils take to leave the peripheral blood circulation and lead to the neutrophil kill function.

A(n)__________ has purple-black granules that obscure the cytoplasm,whereas a(n)__________ contains granules that orange to red in color.

Which of the following peripheral blood pictures is likely to be seen if elevated levels of GM-CSF persist in the bone marrow?

Phagocytosis consumes a large amount of energy provided by what process?

All of the following precursors are found in the mitotic pool except:

An instrument printout shows a WBC count of 4.5 × 10⁹/L with 75% neutrophils.What is the absolute neutrophil count?

What characteristic that is present in promyelocytes morphologically differentiates a promyelocyte from a myeloblast?

The induction of activation-dependent adhesion events depends on adhesion molecules and their ligands located on the leukocyte and what other cell?

Absolute cell count calculation adjusts for what variation(s)?

Basophils contribute to the induction and maintenance of allergic reactions by interacting with B lymphocytes through which molecule?

IL-5 is the cytokine that is required for which cell type to proliferate and terminally differentiate?

Name the cells of the neutrophil lineage in order from earliest morphologically recognizable cell to most mature cell and include one unique morphologic characteristic of each cell.

All of the following are included in the kill mechanism by neutrophils except:

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Filters

A(n) has purple-black granules that obscure the cytoplasm,whereas a(n) contains granules that orange to red in color.