Question 1

Which of the following cytokines stimulate progenitor megakaryocytes to proliferate?

Accepted Answer

A) IL-6 and IL-11 
B) TPO and GM-CSF 
C) EPO and M-CSF 
D) IL-4 and IL-10 
A) IL-6 and IL-11 
B) TPO and GM-CSF 
C) EPO and M-CSF 
D) IL-4 and IL-10 B

Question 2

Platelets are derived from which of the following?

Accepted Answer

A) Monoblasts 
B) Pronormoblasts 
C) Lymphoblasts 
D) Megakaryocytes 
A) Monoblasts 
B) Pronormoblasts 
C) Lymphoblasts 
D) Megakaryocytes D

Question 3

What is the typical concentration of platelets in the blood?

Accepted Answer

A)   
B)    
C)    
D)    
A)   
B)    
C)    
D)    C

Question 4

Which of the following criteria describes giant platelets?

Accepted Answer

A) 8-12 fL in volume 
B) >5 mcM in size 
C) >2N in chromosome number 
D) >400 × 10⁹/L in number 
A) 8-12 fL in volume 
B) >5 mcM in size 
C) >2N in chromosome number 
D) >400 × 10⁹/L in number

Question 5

The effect of thrombopoietin (TPO)on megakaryocytic cells can be described by all of the following except:

Accepted Answer

A) Promote endomitosis 
B) Inhibit proliferation 
C) Increase the number in the bone marrow 
D) Advance the rate of maturation 
A) Promote endomitosis 
B) Inhibit proliferation 
C) Increase the number in the bone marrow 
D) Advance the rate of maturation

Question 6

Which of the following describes how platelet clumping artificially alters platelet parameters?

Accepted Answer

A) Increases both the PDW and the MPV 
B) Decreases both the PDW and the MPV 
C) Increases the PDW and decreases the MPV 
D) Decreases the PDW and increases the MPV 
A) Increases both the PDW and the MPV 
B) Decreases both the PDW and the MPV 
C) Increases the PDW and decreases the MPV 
D) Decreases the PDW and increases the MPV

Question 7

Increased DNA content in exact multiples that are contained within a single nuclear envelope defines cells that are:

Accepted Answer

A) Polyploid 
B) Proliferating 
C) Apoptotic 
D) Differentiated 
A) Polyploid 
B) Proliferating 
C) Apoptotic 
D) Differentiated

Question 8

During what stage of megakaryocyte development are the platelets released into the circulation?

Accepted Answer

A) Between stages III and IV 
B) At the end of stage II 
C) During the cycling phase 
D) At the point of proplatelet formation 
A) Between stages III and IV 
B) At the end of stage II 
C) During the cycling phase 
D) At the point of proplatelet formation

Question 9

Identify the major cytokines that regulate platelet production and describe their effects on megakaryocytic cells and circulating platelets.

Accepted Answer

All stages of megakaryocyte development

Question 10

Which of the following cells is defined as cytoplasmic extensions that are released in groups and fragmented into individual platelets?

Accepted Answer

A) Megakaryocyte 
B) Megakaryoblast 
C) Thrombocyte 
D) Proplatelet 
A) Megakaryocyte 
B) Megakaryoblast 
C) Thrombocyte 
D) Proplatelet

Question 11

Describe megakaryocyte development and the role of endomitosis and thrombopoietin in this process.

Accepted Answer

Platelets develop from megakaryocytes. M

Question 12

Nuclear replication without cytoplasmic division is defined as:

Accepted Answer

A) Asynchrony 
B) Dysmyelopoiesis 
C) Hematopoiesis 
D) Endomitosis 
A) Asynchrony 
B) Dysmyelopoiesis 
C) Hematopoiesis 
D) Endomitosis

Question 13

Which of the following represents a normal platelet number and morphology?

Accepted Answer

A) A platelet that is 10 mcM in size with a blood concentration of 200 × 10⁹/L 
B) A platelet that is 80 mcM in size with a blood concentration of 8 × 10⁹/L 
C) A platelet that is 2.5 mcM in size with a blood concentration of 250 × 10⁹/L 
D) A platelet that is 5 mcM in size with a blood concentration of 600 × 10⁹/L 
A) A platelet that is 10 mcM in size with a blood concentration of 200 × 10⁹/L 
B) A platelet that is 80 mcM in size with a blood concentration of 8 × 10⁹/L 
C) A platelet that is 2.5 mcM in size with a blood concentration of 250 × 10⁹/L 
D) A platelet that is 5 mcM in size with a blood concentration of 600 × 10⁹/L

Question 14

Laboratory results for a patient indicate that the platelet count is 89 × 10⁹/L.What is likely to be observed in the peripheral blood for this patient if the platelet count is the result of increased physiological platelet destruction?

Accepted Answer

A) Megakaryocytes 
B) Megakaryoblasts 
C) Reticulated platelets 
D) Megathrombocytes 
A) Megakaryocytes 
B) Megakaryoblasts 
C) Reticulated platelets 
D) Megathrombocytes

Question 15

On average,how long does a platelet live in the peripheral circulation?

Accepted Answer

A) 6 hours 
B) 120 days 
C) 5 days 
D) 10 days 
A) 6 hours 
B) 120 days 
C) 5 days 
D) 10 days

Question 16

The normal reference interval for the mean platelet volume (MPV)is:

Accepted Answer

A) 9-11 
B) 11-14 g/dL 
C) 150-450 * 10⁹/L 
D) 8-12 fL 
A) 9-11 
B) 11-14 g/dL 
C) 150-450 * 10⁹/L 
D) 8-12 fL

Exam 9: The Platelet

Which of the following cytokines stimulate progenitor megakaryocytes to proliferate?

Platelets are derived from which of the following?

What is the typical concentration of platelets in the blood?

Which of the following criteria describes giant platelets?

The effect of thrombopoietin (TPO)on megakaryocytic cells can be described by all of the following except:

Which of the following describes how platelet clumping artificially alters platelet parameters?

Increased DNA content in exact multiples that are contained within a single nuclear envelope defines cells that are:

During what stage of megakaryocyte development are the platelets released into the circulation?

Identify the major cytokines that regulate platelet production and describe their effects on megakaryocytic cells and circulating platelets.

Which of the following cells is defined as cytoplasmic extensions that are released in groups and fragmented into individual platelets?

Describe megakaryocyte development and the role of endomitosis and thrombopoietin in this process.

Nuclear replication without cytoplasmic division is defined as:

Which of the following represents a normal platelet number and morphology?

Laboratory results for a patient indicate that the platelet count is 89 × 10⁹/L.What is likely to be observed in the peripheral blood for this patient if the platelet count is the result of increased physiological platelet destruction?

On average,how long does a platelet live in the peripheral circulation?

The normal reference interval for the mean platelet volume (MPV)is:

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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