Question 1

CMV infections complicate transplants by which of the following mechanisms?

Accepted Answer

A) Form antibodies to CMV-infected cells that cross-react with stem cells 
B) Suppress normal immune function and elicit the formation of autoantibodies that are lymphocytotoxic 
C) Impair mitotic division of normal hematopoietic cells and stimulate neoplastic cells to proliferate 
D) Stimulate antibodies against RBCs resulting in an autoimmune hemolytic anemia 
A) Form antibodies to CMV-infected cells that cross-react with stem cells 
B) Suppress normal immune function and elicit the formation of autoantibodies that are lymphocytotoxic 
C) Impair mitotic division of normal hematopoietic cells and stimulate neoplastic cells to proliferate 
D) Stimulate antibodies against RBCs resulting in an autoimmune hemolytic anemia A

Question 2

All of the following are expected findings of AIDS except:

Accepted Answer

A) Lymphocytopenia. 
B) Leukocytopenia. 
C) Anemia. 
D) Thrombocytosis. 
A) Lymphocytopenia. 
B) Leukocytopenia. 
C) Anemia. 
D) Thrombocytosis. D

Question 3

Which of the following statements best describes the pathogenesis of HIV infection?

Accepted Answer

A) HIV virus selectively infects T helper cells,incorporates its own DNA into the T helper's DNA,and lyses the cell. 
B) HIV virus infects all lymphocytes,incorporates its own DNA into the T helper's DNA,and changes the T helper's identity. 
C) HIV virus infects all cells involved in cell-mediated immunity,incorporates its own DNA into the DNA of the infected cells,and lyses the cells. 
D) HIV infects T-suppressor cells and initiates apoptosis. 
A) HIV virus selectively infects T helper cells,incorporates its own DNA into the T helper's DNA,and lyses the cell. 
B) HIV virus infects all lymphocytes,incorporates its own DNA into the T helper's DNA,and changes the T helper's identity. 
C) HIV virus infects all cells involved in cell-mediated immunity,incorporates its own DNA into the DNA of the infected cells,and lyses the cells. 
D) HIV infects T-suppressor cells and initiates apoptosis. A

Question 4

Correlate each disorder with the following: (1)population (s)most affected by it,(2)whether it produces a lymphocytosis or lymphocytopenia,(3)morphology associated with it,and (4)pathophysiology of the infection.
a.Infectious mononucleosis
b.Whooping cough
c.Toxoplasmosis
d.CMV infection

Accepted Answer

Infectious mononucleosis
1.Children,teen

Question 5

The prominent lymphocytosis in whooping cough is the result of:

Accepted Answer

A) An exacerbated immune response 
B) Cell-mediated immunity accompanying a neutrophilia 
C) Redistribution of lymphocytes from the lymphatics into peripheral circulation 
D) Increased cytokine stimulation of lymphopoiesis in the bone marrow 
A) An exacerbated immune response 
B) Cell-mediated immunity accompanying a neutrophilia 
C) Redistribution of lymphocytes from the lymphatics into peripheral circulation 
D) Increased cytokine stimulation of lymphopoiesis in the bone marrow

Question 6

A negative heterophile antibody test in a patient with symptoms of infectious mononucleosis could be caused by what factor if the patient is being treated for cancer?

Accepted Answer

A) Infection by another virus 
B) Level of the antibody not high enough to be detected 
C) Immunosuppressed antibody response 
D) CMV infection 
A) Infection by another virus 
B) Level of the antibody not high enough to be detected 
C) Immunosuppressed antibody response 
D) CMV infection

Question 7

What is the agent responsible for infectious mononucleosis?

Accepted Answer

A) Toxoplasmosis 
B) CMV 
C) EBV 
D) Bordetella pertussis 
A) Toxoplasmosis 
B) CMV 
C) EBV 
D) Bordetella pertussis

Question 8

Which of the following is expected to decrease as the HIV infection progresses into AIDS?

Accepted Answer

A) WBC count 
B) CD4:CD8 ratio 
C) Lymphocyte count 
D) All of the above 
A) WBC count 
B) CD4:CD8 ratio 
C) Lymphocyte count 
D) All of the above

Question 9

An unknown patient blood sample has the following results: WBC count = 5 × 10⁹/L with 70% lymphocytes.What term describes this condition?
 Name a disease in which this is seen.

Accepted Answer

The patient has an absolute ly

Question 10

Diagnosis of an active toxoplasmosis infection is established by?

Accepted Answer

A) Molecular tests 
B) Heterophile antibody test 
C) Biopsy of lymph nodes from various sites 
D) Rising titer and seroconversion of antibodies to Toxoplasma gondii 
A) Molecular tests 
B) Heterophile antibody test 
C) Biopsy of lymph nodes from various sites 
D) Rising titer and seroconversion of antibodies to Toxoplasma gondii

Question 11

Correlate antibody titers with the stage of infection.What antibody titer excludes current infection?

Accepted Answer

Current infection: EBV-CA IgG: >1:60;EBV

Question 12

The Epstein-Barr virus targets B cells that express _______.Once infected,they cause expression of the_______ marker.

Accepted Answer

A) CD21;CD23 
B) CD23;CD21 
C) CD22;CD23 
D) CD34;CD19 
A) CD21;CD23 
B) CD23;CD21 
C) CD22;CD23 
D) CD34;CD19

Question 13

Lymphocytosis is found about 1 week after symptoms appear in infectious mononucleosis and lymphocytes remain elevated for 2-8 weeks.What morphologic characteristics are present in the blood smear?

Accepted Answer

A) Leukemic lymphoblasts 
B) Reactive lymphocytes with mild thrombocytopenia 
C) Decreased lymphocytes 
D) Homogeneous lymphocyte population 
A) Leukemic lymphoblasts 
B) Reactive lymphocytes with mild thrombocytopenia 
C) Decreased lymphocytes 
D) Homogeneous lymphocyte population

Question 14

What are the most common laboratory findings in CMV infection in the newborn?

Accepted Answer

A) Thrombocytopenia and hemolytic anemia 
B) Leukocytosis 
C) Positive heterophile agglutinin test. 
D) Viral DNA assay is negative. 
A) Thrombocytopenia and hemolytic anemia 
B) Leukocytosis 
C) Positive heterophile agglutinin test. 
D) Viral DNA assay is negative.

Question 15

A patient with infectious mononucleosis is having serologic blood tests.Results are as follows: EBVCA IgG: 1:320;EBVCA IgM: not detected;EBNA: 1:20.What stage of infection is the patient in?

Accepted Answer

A) Acute 
B) Recent 
C) Past 
D) Cannot be determined 
A) Acute 
B) Recent 
C) Past 
D) Cannot be determined

Question 16

Which of the following disorders is associated with a lymphocytosis?

Accepted Answer

A) X-linked immunodeficiency syndrome 
B) AIDS 
C) Whooping cough 
D) SCID 
A) X-linked immunodeficiency syndrome 
B) AIDS 
C) Whooping cough 
D) SCID

Question 17

A 5-year-old patient is suspected of having infectious mononucleosis.The patient's blood smear reveals 55% reactive lymphocytes and a WBC count of 15 × 10⁹/L.The heterophile antibody test is negative.IgG and IgM antibodies to EBV both come back positive.What is the best explanation for these results?

Accepted Answer

A) When infected with EBV,50% of children under the age of 10 do not have a positive heterophile test. 
B) The patient does not have EBV but acute lymphoid leukemia. 
C) The serologic tests are false positive for IgG and IgM antibodies to EBV. 
D) The heterophile test is never positive in children under 10 years of age. 
A) When infected with EBV,50% of children under the age of 10 do not have a positive heterophile test. 
B) The patient does not have EBV but acute lymphoid leukemia. 
C) The serologic tests are false positive for IgG and IgM antibodies to EBV. 
D) The heterophile test is never positive in children under 10 years of age.

Question 18

A 5-year-old girl has a WBC count of 11 × 10⁹/L with 55% lymphocytes.Which of the following best describes this phenomenon?

Accepted Answer

A) Absolute lymphocytosis 
B) Relative lymphocytosis 
C) Normal leukocyte count 
D) Absolute lymphocytopenia 
A) Absolute lymphocytosis 
B) Relative lymphocytosis 
C) Normal leukocyte count 
D) Absolute lymphocytopenia

Question 19

Name five hematologic findings associated with HIV infections other than lymphocytopenia.

Accepted Answer

Anemia,thrombocytope

Question 20

Which of the following is an expected finding regarding the morphology of an activated lymphocyte that is different from a normal lymphocyte?

Accepted Answer

A) Oval nucleus 
B) Prominent nucleoli 
C) Abundant cytoplasm 
D) Clumped chromatin 
A) Oval nucleus 
B) Prominent nucleoli 
C) Abundant cytoplasm 
D) Clumped chromatin

Exam 22: Nonmalignant Lymphocyte Disorders

CMV infections complicate transplants by which of the following mechanisms?

All of the following are expected findings of AIDS except:

Which of the following statements best describes the pathogenesis of HIV infection?

Correlate each disorder with the following: (1)population (s)most affected by it,(2)whether it produces a lymphocytosis or lymphocytopenia,(3)morphology associated with it,and (4)pathophysiology of the infection. a.Infectious mononucleosis b.Whooping cough c.Toxoplasmosis d.CMV infection

The prominent lymphocytosis in whooping cough is the result of:

A negative heterophile antibody test in a patient with symptoms of infectious mononucleosis could be caused by what factor if the patient is being treated for cancer?

What is the agent responsible for infectious mononucleosis?

Which of the following is expected to decrease as the HIV infection progresses into AIDS?

An unknown patient blood sample has the following results: WBC count = 5 × 10⁹/L with 70% lymphocytes.What term describes this condition? Name a disease in which this is seen.

Diagnosis of an active toxoplasmosis infection is established by?

Correlate antibody titers with the stage of infection.What antibody titer excludes current infection?

The Epstein-Barr virus targets B cells that express _______.Once infected,they cause expression of the_______ marker.

Lymphocytosis is found about 1 week after symptoms appear in infectious mononucleosis and lymphocytes remain elevated for 2-8 weeks.What morphologic characteristics are present in the blood smear?

What are the most common laboratory findings in CMV infection in the newborn?

A patient with infectious mononucleosis is having serologic blood tests.Results are as follows: EBVCA IgG: 1:320;EBVCA IgM: not detected;EBNA: 1:20.What stage of infection is the patient in?

Which of the following disorders is associated with a lymphocytosis?

A 5-year-old girl has a WBC count of 11 × 10⁹/L with 55% lymphocytes.Which of the following best describes this phenomenon?

Name five hematologic findings associated with HIV infections other than lymphocytopenia.

Which of the following is an expected finding regarding the morphology of an activated lymphocyte that is different from a normal lymphocyte?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Filters

The Epstein-Barr virus targets B cells that express _.Once infected,they cause expression of the_ marker.