Question 1

What component is responsible for the accumulation of lymphocytes in the blood during a whooping cough infection?

Accepted Answer

A) Pertussis toxin 
B) Leukemoid reaction 
C) T lymphocytes 
D) VCA-IgG 
A) Pertussis toxin 
B) Leukemoid reaction 
C) T lymphocytes 
D) VCA-IgG

Question 2

A 19-year-old male visits his physician because of a persistent cough and progressive fatigue over the past month.Physical examination reveals prominent lymphadenopathy.Laboratory analysis reveals a WBC count of 20 × 10⁹/L with 23% reactive lymphocytes.Patient serum is positive for both IgG and IgM antibodies against EBV.Based on this information,from what is the patient most likely suffering?

Accepted Answer

A) Hodgkin lymphoma 
B) Reactive leukocytosis 
C) Infectious mononucleosis 
D) Malaria 
A) Hodgkin lymphoma 
B) Reactive leukocytosis 
C) Infectious mononucleosis 
D) Malaria

Question 3

Bordetella pertussis is characterized by rapid peripheral lymphocytosis and decreased cellularity of the lymph nodes.What can explain this phenomenon?

Accepted Answer

A) Loss of homing of B cells to lymphoid tissues 
B) Loss of homing of T cells to lymphoid tissue 
C) Abnormal homing of lymphocytes to the bone marrow 
D) Increase of L-selectin expression by T cells 
A) Loss of homing of B cells to lymphoid tissues 
B) Loss of homing of T cells to lymphoid tissue 
C) Abnormal homing of lymphocytes to the bone marrow 
D) Increase of L-selectin expression by T cells

Question 4

Bordetella pertussis and chronic lymphocytic leukemia have increased small lymphocytes with condensed nuclear chromatin on the blood smear.What laboratory test could distinguish whooping cough from CLL?

Accepted Answer

A) Heterophile testing 
B) Biopsy of lymph nodes 
C) Molecular testing 
D) Culture and serological antibody testing 
A) Heterophile testing 
B) Biopsy of lymph nodes 
C) Molecular testing 
D) Culture and serological antibody testing

Question 5

What clinical condition does the Centers for Disease Control and Prevention include in its case definition for HIV infection?

Accepted Answer

A) Bordetella pertussis 
B) Infectious mononucleosis 
C) Kaposi's sarcoma 
D) Plasmacytosis 
A) Bordetella pertussis 
B) Infectious mononucleosis 
C) Kaposi's sarcoma 
D) Plasmacytosis

Question 6

Compare and contrast X-linked SCID and autosomal SCID.

Accepted Answer

Classic X-linked SCID accounts for 45% o

Question 7

An 18-year old patient has a WBC count of 9 ×10⁹/L and 60% lymphs,30% neutrophils,6% monocytes,3% eosinophils,and 1% basophils.The following that best describe this condition are:

Accepted Answer

A) Relative and absolute neutrophilia. 
B) Absolute neutropenia and absolute lymphocytosis. 
C) Relative neutropenia and absolute lymphocytosis. 
D) Relative lymphocytopenia and relative neutropenia. 
A) Relative and absolute neutrophilia. 
B) Absolute neutropenia and absolute lymphocytosis. 
C) Relative neutropenia and absolute lymphocytosis. 
D) Relative lymphocytopenia and relative neutropenia.

Question 8

Which of the following infectious agents that can be transmitted from mother to a growing fetus can result in physically and mentally impaired development?

Accepted Answer

A) Bordetella pertussis 
B) Toxoplasma gondii 
C) Coxsackievirus A 
D) Clostridium botulinum 
A) Bordetella pertussis 
B) Toxoplasma gondii 
C) Coxsackievirus A 
D) Clostridium botulinum

Question 9

What characteristics are associated with reactive lymphocytes?

Accepted Answer

A) They can contain vacuoles,and chromatin pattern is very fine. 
B) They can contain vacuoles,deep blue abundant cytoplasm. 
C) Their nucleus has a fine chromatin pattern,and the N:C ratio is increased. 
D) They have high N:C ratio with a small amount of deep blue cytoplasm. 
A) They can contain vacuoles,and chromatin pattern is very fine. 
B) They can contain vacuoles,deep blue abundant cytoplasm. 
C) Their nucleus has a fine chromatin pattern,and the N:C ratio is increased. 
D) They have high N:C ratio with a small amount of deep blue cytoplasm.

Question 10

Which of the following is used as a screening test for infectious mononucleosis?

Accepted Answer

A) Heterophile antibody test 
B) EBV IgG and IgM tests 
C) HBsAg 
D) ANA IFA 
A) Heterophile antibody test 
B) EBV IgG and IgM tests 
C) HBsAg 
D) ANA IFA

Question 11

Which of the following cell types is commonly infected by the HIV-1 virus?

Accepted Answer

A) Cytotoxic T cell 
B) CD8 cell 
C) CD4 cell 
D) Neutrophil 
A) Cytotoxic T cell 
B) CD8 cell 
C) CD4 cell 
D) Neutrophil

Question 12

A 42-year-old HIV-positive patient recently was diagnosed with disseminated histoplasmosis.Which of the following should be ordered to monitor this patient's progression?

Accepted Answer

A) HIV antibody screen 
B) HBsAg 
C) CBC 
D) CD4:CD8 ratio 
A) HIV antibody screen 
B) HBsAg 
C) CBC 
D) CD4:CD8 ratio

Exam 22: Nonmalignant Lymphocyte Disorders

What component is responsible for the accumulation of lymphocytes in the blood during a whooping cough infection?

Bordetella pertussis is characterized by rapid peripheral lymphocytosis and decreased cellularity of the lymph nodes.What can explain this phenomenon?

Bordetella pertussis and chronic lymphocytic leukemia have increased small lymphocytes with condensed nuclear chromatin on the blood smear.What laboratory test could distinguish whooping cough from CLL?

What clinical condition does the Centers for Disease Control and Prevention include in its case definition for HIV infection?

Compare and contrast X-linked SCID and autosomal SCID.

An 18-year old patient has a WBC count of 9 ×10⁹/L and 60% lymphs,30% neutrophils,6% monocytes,3% eosinophils,and 1% basophils.The following that best describe this condition are:

Which of the following infectious agents that can be transmitted from mother to a growing fetus can result in physically and mentally impaired development?

What characteristics are associated with reactive lymphocytes?

Which of the following is used as a screening test for infectious mononucleosis?

Which of the following cell types is commonly infected by the HIV-1 virus?

A 42-year-old HIV-positive patient recently was diagnosed with disseminated histoplasmosis.Which of the following should be ordered to monitor this patient's progression?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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