Question 1

Which of the following is a complication of leukemia treatment?

Accepted Answer

A) Increased uric acid levels 
B) Graft-versus-host disease 
C) DIC 
D) All of the above 
A) Increased uric acid levels 
B) Graft-versus-host disease 
C) DIC 
D) All of the above D

Question 2

Which of the following laboratory analyses can be used to diagnose hematopoietic neoplasms?

Accepted Answer

A) Cell morphology 
B) Immunophenotyping 
C) Cytogenetics 
D) All of the above 
A) Cell morphology 
B) Immunophenotyping 
C) Cytogenetics 
D) All of the above D

Question 3

Which two stains are used to differentiate the myeloid from the lymphoid blasts?

Accepted Answer

A) MPO and SBB 
B) PAS and LAP 
C) Acid phosphatase and LAP 
D) Toluidine blue and reticulin stain 
A) MPO and SBB 
B) PAS and LAP 
C) Acid phosphatase and LAP 
D) Toluidine blue and reticulin stain A

Question 4

How are oncogenes and proto-oncogenes different?

Accepted Answer

A) Proto-oncogenes are activated tumor genes,whereas oncogenes are inactivated tumor suppressor genes. 
B) Oncogenes can lead to tumor formation,whereas proto-oncogenes prevent tumor formation. 
C) Oncogenes can lead to tumor formation,whereas proto-oncogenes are inactivated forms of oncogenes. 
D) Oncogenes are tumor suppressors,whereas proto-oncogenes cause tumor formation. 
A) Proto-oncogenes are activated tumor genes,whereas oncogenes are inactivated tumor suppressor genes. 
B) Oncogenes can lead to tumor formation,whereas proto-oncogenes prevent tumor formation. 
C) Oncogenes can lead to tumor formation,whereas proto-oncogenes are inactivated forms of oncogenes. 
D) Oncogenes are tumor suppressors,whereas proto-oncogenes cause tumor formation.

Question 5

Name the two main classification systems that identify MDS and acute leukemia.Indicate how they are different.

Accepted Answer

Each can be classified by WHO

Question 6

Which of the following disorders is characterized by signs of dyshematopoiesis?

Accepted Answer

A) Acute leukemias 
B) Chronic leukemias 
C) Myelodysplastic syndromes 
D) Myeloproliferative disorders 
A) Acute leukemias 
B) Chronic leukemias 
C) Myelodysplastic syndromes 
D) Myeloproliferative disorders

Question 7

Which of the following does the World Health Organization use to classify hematopoietic neoplasms?

Accepted Answer

A) Lineage morphology 
B) Clinical presentation 
C) HIV status 
D) DNA profiling 
A) Lineage morphology 
B) Clinical presentation 
C) HIV status 
D) DNA profiling

Question 8

A routine CBC from a 5-year-old boy shows 90% blasts in peripheral circulation.Cytochemical staining with MPO and SBB was negative.Based on these findings,from what is the patient most likely suffering?

Accepted Answer

A) AML 
B) ALL 
C) CML 
D) CLL 
A) AML 
B) ALL 
C) CML 
D) CLL

Question 9

A malignant neoplasm is best described as which of the following?

Accepted Answer

A) A clone of normal,proliferating cells 
B) A clone of abnormal,anaplastic,proliferating cells that have the potential to metastasize 
C) A clone of highly organized,differentiated cells that have the potential to metastasize 
D) A clone of highly organized,differentiated cells that do not spread 
A) A clone of normal,proliferating cells 
B) A clone of abnormal,anaplastic,proliferating cells that have the potential to metastasize 
C) A clone of highly organized,differentiated cells that have the potential to metastasize 
D) A clone of highly organized,differentiated cells that do not spread

Question 10

Cell lineage of leukemic blasts can be determined by:

Accepted Answer

A) Morphology,cytochemical stains,cell concentration 
B) Cytochemical stains,immunophenotyping 
C) Presence of Auer rods and Pappenheimer bodies 
D) Immaturity of cytoplasm and presence of nuclear phi bodies 
A) Morphology,cytochemical stains,cell concentration 
B) Cytochemical stains,immunophenotyping 
C) Presence of Auer rods and Pappenheimer bodies 
D) Immaturity of cytoplasm and presence of nuclear phi bodies

Question 11

In what age group does chronic leukemia usually occur?

Accepted Answer

A) All 
B) Children 
C) Adults 
D) 15-20 years of age 
A) All 
B) Children 
C) Adults 
D) 15-20 years of age

Question 12

What is(are)the common complication(s)of chemotherapy?

Accepted Answer

A) Bleeding,infection,and anemia 
B) Bone marrow rejection 
C) Thrombocytosis 
D) Refractory anemia 
A) Bleeding,infection,and anemia 
B) Bone marrow rejection 
C) Thrombocytosis 
D) Refractory anemia

Question 13

A bone marrow differential is performed on a patient suspected of having leukemia.Cytochemical stains are performed.MPO and SBB are negative.Blasts appear homogeneous and small in size.What would you expect to find when performing immunophenotyping?

Accepted Answer

A) Positive reactivity with immature B-cell or T-cell markers 
B) Positive reactivity with immature myeloid markers 
C) Positive reactivity with mature myeloid markers 
D) Positive reactivity with plasma cell markers 
A) Positive reactivity with immature B-cell or T-cell markers 
B) Positive reactivity with immature myeloid markers 
C) Positive reactivity with mature myeloid markers 
D) Positive reactivity with plasma cell markers

Question 14

A patient has a WBC count of 250 × 10⁹/L,and a peripheral blood smear contains many granulocytes and granulocytic precursors including 2% blasts.Pending further tests,which of the following neoplastic conditions is the most likely diagnosis?

Accepted Answer

A) Chronic myeloid leukemia 
B) Lymphoblastic leukemia 
C) Chronic lymphocytic leukemia 
D) Acute myeloid leukemia 
A) Chronic myeloid leukemia 
B) Lymphoblastic leukemia 
C) Chronic lymphocytic leukemia 
D) Acute myeloid leukemia

Question 15

Leukemias are classified as:

Accepted Answer

A) Benign neoplasms 
B) Malignant neoplasms 
C) Neoplasms 
D) Benign tumors 
A) Benign neoplasms 
B) Malignant neoplasms 
C) Neoplasms 
D) Benign tumors

Question 16

Which of the following has the best prognosis?

Accepted Answer

A) ALL in children 
B) ALL in adults 
C) AML in adults 
D) AML in children 
A) ALL in children 
B) ALL in adults 
C) AML in adults 
D) AML in children

Question 17

Which patient population is most affected by acute lymphoblastic leukemia?

Accepted Answer

A) Children 
B) Adults 
C) Geriatrics 
D) Females 
A) Children 
B) Adults 
C) Geriatrics 
D) Females

Question 18

Bleeding,infections,and anemia are common complications of chemotherapy because:

Accepted Answer

A) Drugs are used kill normal cells as well as leukemic cells. 
B) Normal cells are more susceptible to drug-induced apoptosis than leukemic cells. 
C) Drugs bind preferentially to normal cells. 
D) Drugs induce the formation of autoantibodies to normal cells. 
A) Drugs are used kill normal cells as well as leukemic cells. 
B) Normal cells are more susceptible to drug-induced apoptosis than leukemic cells. 
C) Drugs bind preferentially to normal cells. 
D) Drugs induce the formation of autoantibodies to normal cells.

Question 19

Which of the following combinations leads to tumor formation?

Accepted Answer

A) Activation of oncogenes and suppression of proto-oncogenes 
B) Activation of proto-oncogenes with concurrent suppression of oncogenes 
C) Activation of oncogenes and suppression of tumor-suppressor genes 
D) Activation of tumor suppressor genes and suppression of proto-oncogenes 
A) Activation of oncogenes and suppression of proto-oncogenes 
B) Activation of proto-oncogenes with concurrent suppression of oncogenes 
C) Activation of oncogenes and suppression of tumor-suppressor genes 
D) Activation of tumor suppressor genes and suppression of proto-oncogenes

Question 20

Which of the following have the potential to progress into acute leukemia:

Accepted Answer

A) Myeloproliferative neoplasms 
B) Acute neutrophilia 
C) Megaloblastic anemias 
D) Reactive leukocytosis 
A) Myeloproliferative neoplasms 
B) Acute neutrophilia 
C) Megaloblastic anemias 
D) Reactive leukocytosis

Exam 23: Introduction to Hematopoietic Neoplasms

Which of the following is a complication of leukemia treatment?

Which of the following laboratory analyses can be used to diagnose hematopoietic neoplasms?

Which two stains are used to differentiate the myeloid from the lymphoid blasts?

How are oncogenes and proto-oncogenes different?

Name the two main classification systems that identify MDS and acute leukemia.Indicate how they are different.

Which of the following disorders is characterized by signs of dyshematopoiesis?

Which of the following does the World Health Organization use to classify hematopoietic neoplasms?

A routine CBC from a 5-year-old boy shows 90% blasts in peripheral circulation.Cytochemical staining with MPO and SBB was negative.Based on these findings,from what is the patient most likely suffering?

A malignant neoplasm is best described as which of the following?

Cell lineage of leukemic blasts can be determined by:

In what age group does chronic leukemia usually occur?

What is(are)the common complication(s)of chemotherapy?

A bone marrow differential is performed on a patient suspected of having leukemia.Cytochemical stains are performed.MPO and SBB are negative.Blasts appear homogeneous and small in size.What would you expect to find when performing immunophenotyping?

A patient has a WBC count of 250 × 10⁹/L,and a peripheral blood smear contains many granulocytes and granulocytic precursors including 2% blasts.Pending further tests,which of the following neoplastic conditions is the most likely diagnosis?

Leukemias are classified as:

Which of the following has the best prognosis?

Which patient population is most affected by acute lymphoblastic leukemia?

Bleeding,infections,and anemia are common complications of chemotherapy because:

Which of the following combinations leads to tumor formation?

Which of the following have the potential to progress into acute leukemia:

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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