Question 1

Which laboratory test confirms the lineage of hematologic neoplasms?

Accepted Answer

A) Cytogenetic analysis 
B) Immunophenotyping 
C) Nuclear staining 
D) Bone marrow differential 
A) Cytogenetic analysis 
B) Immunophenotyping 
C) Nuclear staining 
D) Bone marrow differential

Question 2

The HSC and the cancer stem cell are similar in:

Accepted Answer

A) Morphology 
B) CD markers 
C) Cytochemical staining 
D) Replicating potential 
A) Morphology 
B) CD markers 
C) Cytochemical staining 
D) Replicating potential

Question 3

Explain how proto-oncogenes contribute to tumor formation.

Accepted Answer

Proto-oncogenes can become act

Question 4

The purpose of the induction phase in chemotherapy is to:

Accepted Answer

A) Eradicate normal cells 
B) Eradicate tumor cells 
C) Initiate an immune response against tumors 
D) Help the patient tolerate the tumor 
A) Eradicate normal cells 
B) Eradicate tumor cells 
C) Initiate an immune response against tumors 
D) Help the patient tolerate the tumor

Question 5

An abundance of blasts and some mature forms with an apparent decrease in the intermediate maturational stages is referred to as:

Accepted Answer

A) Acute lymphoid leukemia 
B) Chronic myelogenous leukemia 
C) Chronic lymphocytic leukemia 
D) Leukemic hiatus. 
A) Acute lymphoid leukemia 
B) Chronic myelogenous leukemia 
C) Chronic lymphocytic leukemia 
D) Leukemic hiatus.

Question 6

Which progenitor cells normally do not have the capacity for self-renewal?

Accepted Answer

A) CMP and CLP 
B) HSC 
C) Somatic cells 
D) Primitive hematopoietic precursor cells 
A) CMP and CLP 
B) HSC 
C) Somatic cells 
D) Primitive hematopoietic precursor cells

Question 7

TSG,or the tumor suppressor gene,plays a role in neoplastic transformation of cells by what mechanism?

Accepted Answer

A) Suppressing the cellular proliferation and neoplastic transformation 
B) Initiating the cellular proliferation 
C) Triggering the proto-oncogenes to activate to oncogenes 
D) Initiating translocation of genes 
A) Suppressing the cellular proliferation and neoplastic transformation 
B) Initiating the cellular proliferation 
C) Triggering the proto-oncogenes to activate to oncogenes 
D) Initiating translocation of genes

Question 8

A gene involved in regulating the growth of myeloid cells is hypermethylated,resulting in a block in transcription.This is an example of malignancy as a result of:

Accepted Answer

A) Post-translational modification 
B) DNA mutation 
C) Epigenetic change 
D) Genomic instability 
A) Post-translational modification 
B) DNA mutation 
C) Epigenetic change 
D) Genomic instability

Question 9

Which disease state has Auer bodies present on examination of the blood smear?

Accepted Answer

A) MDS 
B) MPD 
C) MDS/MPD 
D) AML 
A) MDS 
B) MPD 
C) MDS/MPD 
D) AML

Question 10

Somatic cell chromosome mutations resulting in hematologic neoplasms are associated with:

Accepted Answer

A) Chemicals,drugs,bacterial infection 
B) Drugs,chemicals,renal disease 
C) Therapeutic radiation,drugs and chemicals 
D) Viral and bacterial infections,autoantibodies 
A) Chemicals,drugs,bacterial infection 
B) Drugs,chemicals,renal disease 
C) Therapeutic radiation,drugs and chemicals 
D) Viral and bacterial infections,autoantibodies

Question 11

What is the difference between the HSC and the cancer stem cell?

Accepted Answer

The cancer stem cell has unlim

Question 12

Which of the following cytochemical stains can help differentiate AML from ALL?

Accepted Answer

A) PAS stain 
B) LAP stain 
C) MPO stain 
D) NSE stain 
A) PAS stain 
B) LAP stain 
C) MPO stain 
D) NSE stain

Question 13

For the following cytochemical stains,indicate (1)what they stain and (2)their disease correlation to a positive result.
a.MPO
b.SBB
c.NSE
d.PAS

Accepted Answer

MPO: (1)primary granules;(2)AML
SBB: (1)

Question 14

All of the following have been proposed as being leukemogenic except:

Accepted Answer

A) Therapeutic radiation 
B) Living in high altitude 
C) Chromosome translocation 
D) Benzene 
A) Therapeutic radiation 
B) Living in high altitude 
C) Chromosome translocation 
D) Benzene

Exam 23: Introduction to Hematopoietic Neoplasms

Which laboratory test confirms the lineage of hematologic neoplasms?

The HSC and the cancer stem cell are similar in:

Explain how proto-oncogenes contribute to tumor formation.

The purpose of the induction phase in chemotherapy is to:

An abundance of blasts and some mature forms with an apparent decrease in the intermediate maturational stages is referred to as:

Which progenitor cells normally do not have the capacity for self-renewal?

TSG,or the tumor suppressor gene,plays a role in neoplastic transformation of cells by what mechanism?

A gene involved in regulating the growth of myeloid cells is hypermethylated,resulting in a block in transcription.This is an example of malignancy as a result of:

Which disease state has Auer bodies present on examination of the blood smear?

Somatic cell chromosome mutations resulting in hematologic neoplasms are associated with:

What is the difference between the HSC and the cancer stem cell?

Which of the following cytochemical stains can help differentiate AML from ALL?

For the following cytochemical stains,indicate (1)what they stain and (2)their disease correlation to a positive result. a.MPO b.SBB c.NSE d.PAS

All of the following have been proposed as being leukemogenic except:

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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