Exam 20: Hemolytic Anemia: Nonimmune Defects

A runner is in training for the Chicago Marathon.After his most recent 26 mile run,he notices that his urine was reddish-brown.The next morning,his urine is clear and yellow,but he decided to see his primary care physician.All of the hematology and chemistry results are within the reference range.What is the most likely reason for this scenario?

Laboratory testing in DIC helps distinguish this condition from others.Which of the following results would be expected in DIC?

The destruction of erythrocytes in MAHA is primarily the result of what mechanism?

Which of following is identified as an initiator of exercise-induced hemoglobinuria associated with running?

A woman visits her obstetrician for a routine prenatal visit at 24 weeks.Her blood pressure is 180/100 and her urinalysis shows 3+ proteins.The peripheral blood smear demonstrated the presence of schistocytes.What other elevated test results might be found?

The primary difference between D+ and D- forms of HUS is related to the:

Which of the following analytes is decreased in HUS?

A child presents to the hospital emergency department with clinical findings of bloody diarrhea and fever.Laboratory findings reveal an elevated neutrophil count,increased C-reactive protein,thrombocytopenia,and a decreased haptoglobin.With what diagnosis are these findings associated ?

A 20-year-old disoriented female is brought to the hospital with a fever of 102°F.Results of the CBC demonstrate a platelet count of 68 × 10⁹/L,a hemoglobin of 9.0 gm/dl,WBC count of 22 × 10⁹/L,and the presence of polychromasia and schistocytes on the peripheral blood smear.Her husband indicated she had no recent episodes of diarrhea but had been taking penicillin for an ongoing infection.The most likely diagnosis for the patient is:

What features are identified on the peripheral blood smear in TTP?

Which of the following analytes would be increased in MAHA?

Describe the mechanism that causes the production of schistocytes in microangiopathic hemolytic anemia.

What are typical findings on the blood smear in DIC?

A patient presented with fever,mild anemia,and thrombocytopenia.The peripheral blood smear showed the presence of intracellular organisms that were present as singles,doubles,and tetrads.What is the most likely identification of the organism?

Which of the following organisms causes erythrocyte damage by releasing hemolytic toxins?

In what type of hemolytic anemia does damage to the endothelial lining of the small vessels result in deposits of fibrin with the vessels?

The type of anemia commonly associated with HUS is:

Explain how the action of E.coli O157:H7 toxin is related to the development of HUS.

Hemolytic uremic syndrome and thrombotic thrombocytopenic purpura can present with similar initial clinical symptoms.Which of following distinguishes TTP?

Which of the following is found to be a factor in TTP?