Question 1

Which of the following conditions is not characterized by the presence of schistocytes?

Accepted Answer

A) HUS 
B) TTP 
C) Malaria 
D) HELLP syndrome 
A) HUS 
B) TTP 
C) Malaria 
D) HELLP syndrome

Question 2

A mother brings her 3-year-old daughter to the emergency department because she is having trouble urinating.The child is not feverish.She has otherwise been healthy except for a bout of diarrhea about 10 days ago.Laboratory test results are as follows:  
Based on the history and the laboratory results,what is the most likely diagnosis?

Accepted Answer

A) DIC 
B) Bartonella sp.infection 
C) HUS 
D) Previous Clostridium sp.infection 
A) DIC 
B) Bartonella sp.infection 
C) HUS 
D) Previous Clostridium sp.infection

Question 3

Explain why infections with Clostridium perfringens lead to hemolysis of the RBCs.

Accepted Answer

C. perfringens releases an endotoxin (al

Question 4

A 7-year-old girl is brought to a physician because she has a swollen hand with an ischemic lesion.The physician suspects a brown recluse spider bite.What is the suspected mechanism of erythrocyte damage caused by venom of this spider?

Accepted Answer

A) Changes in glycophorin on the erythrocyte membrane 
B) DIC 
C) Lysis caused by passage through the fibrin clot 
D) Changes in the permeability of the cell membrane 
A) Changes in glycophorin on the erythrocyte membrane 
B) DIC 
C) Lysis caused by passage through the fibrin clot 
D) Changes in the permeability of the cell membrane

Question 5

Which of the following laboratory findings occur in both HUS and TTP?

Accepted Answer

A) Increased reticulocytes;thrombocytopenia;decrease in haptoglobin 
B) Decreased reticulocytes;decrease in haptoglobin and thrombocytopenia 
C) Increased total and unconjugated serum bilirubin;increase in haptoglobin 
D) Decreased total and unconjugated serum bilirubin;decreased haptoglobin 
A) Increased reticulocytes;thrombocytopenia;decrease in haptoglobin 
B) Decreased reticulocytes;decrease in haptoglobin and thrombocytopenia 
C) Increased total and unconjugated serum bilirubin;increase in haptoglobin 
D) Decreased total and unconjugated serum bilirubin;decreased haptoglobin

Question 6

Bone marrow response in MAHA is reflected in the peripheral blood smear by the presence of:

Accepted Answer

A) Spherocytes 
B) Reticulocytes 
C) Schistocytes 
D) Keratocytes 
A) Spherocytes 
B) Reticulocytes 
C) Schistocytes 
D) Keratocytes

Question 7

The underlying cause of TTP is:

Accepted Answer

A) An unregulated coagulation cascade 
B) Deficiency in VWF multimers 
C) Deficiency of ADAMTS-13 protease 
D) Overproduction of cryoprecipitate 
A) An unregulated coagulation cascade 
B) Deficiency in VWF multimers 
C) Deficiency of ADAMTS-13 protease 
D) Overproduction of cryoprecipitate

Question 8

Which of the following results are typically found in HUS?
PT aPTT

Accepted Answer

A) ProlongedProlonged 
B) NormalProlonged 
C) ProlongedNormal 
D) NormalNormal 
A) ProlongedProlonged 
B) NormalProlonged 
C) ProlongedNormal 
D) NormalNormal

Question 9

Plasmodium falciparum infection is accompanied by a severe form of anemia from what factor?

Accepted Answer

A) Toxins produced by P.falciparum 
B) High levels of parasitemia 
C) Lack of spleen removal of the infected cells (red blood cells) 
D) Production of exotoxins that affect host cell membranes 
A) Toxins produced by P.falciparum 
B) High levels of parasitemia 
C) Lack of spleen removal of the infected cells (red blood cells) 
D) Production of exotoxins that affect host cell membranes

Question 10

A patient who presents with DIC would most likely have which of the following sets of coagulation test results?
PT aPTT D-dimer Fibrinogen

Accepted Answer

A) ProlongedProlongedElevatedDecreased 
B) NormalProlongedNormalNormal 
C) ProlongedProlongedDecreasedIncreased 
D) NormalProlongedDecreasedDecreased 
A) ProlongedProlongedElevatedDecreased 
B) NormalProlongedNormalNormal 
C) ProlongedProlongedDecreasedIncreased 
D) NormalProlongedDecreasedDecreased

Exam 20: Hemolytic Anemia: Nonimmune Defects

Which of the following conditions is not characterized by the presence of schistocytes?

Explain why infections with Clostridium perfringens lead to hemolysis of the RBCs.

A 7-year-old girl is brought to a physician because she has a swollen hand with an ischemic lesion.The physician suspects a brown recluse spider bite.What is the suspected mechanism of erythrocyte damage caused by venom of this spider?

Which of the following laboratory findings occur in both HUS and TTP?

Bone marrow response in MAHA is reflected in the peripheral blood smear by the presence of:

The underlying cause of TTP is:

Which of the following results are typically found in HUS? PT aPTT

Plasmodium falciparum infection is accompanied by a severe form of anemia from what factor?

A patient who presents with DIC would most likely have which of the following sets of coagulation test results? PT aPTT D-dimer Fibrinogen

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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