Exam 34: Disorders of Secondary Hemostasis

Which assay would assess for the presence of a circulating nonspecific inhibitor?

Hemophilia A is caused by a deficiency in which of the following proteins?

George Jones is admitted to the hospital with abdominal pain.Upon physical examination,the attending physician notices a yellow ring around his green eyes.George has a significant swelling in his abdomen and has been suffering from swollen joints for the last month.The physician runs a battery of labs.The results follow: Based on this information,from what is George most likely suffering?

Deficiencies of the fibrin-forming proteins often have a delayed bleeding symptom that results from which of the following?

A 5-year-old boy has his blood drawn for platelet aggregation studies.Ristocetin aggregation (RIPA)comes back abnormal with all other agonists displaying normal aggregation.VWF antigen is within normal limits.What is the most likely reason for this discrepancy?

F-VIII deficiency and F-IX deficiency are classified as what category of disorder?

What term describes hereditary or acquired disorders that relate to the absence of a coagulation protein or to a protein that is present in the plasma but is functionally defective?

An advantage of prenatal diagnosis by genotypic analysis for hemophilia over phenotypic analysis is:

From what disorder is the patient suffering?

Deficiency of coagulation proteins is defined as a decrease in:

Predict results that will confirm the patient's diagnosis.

Interpret the following results: PT: 11.8 sec (RR: 11.2-13.8 sec) INR: 1.07 APTT: 57 sec (RR: 23-32 sec) BT: 12 min Ristocetin aggregation: decreased aggregation Based on this information,from what is the patient most likely suffering?

What plasma factor levels of the deficient factor can be expected in a female carrier of FVIII or FIX deficiency?

A known hemophiliac has developed an inhibitor.The physician in charge of his care wants to know how much inhibitor is present to properly treat him.What two lab tests would be ordered to assess this?

Which is the most common FVIII mutation in patients with a severe phenotype (occurring in almost 50% of patients)?

A patient has a prolonged PT.Which deficiency can you infer from this result?

Which of the following clinical symptoms correlates with a severe form of hemophilia A or B?

Which of the following is used in the identification of a secondary hemostatic pathway anomaly?

Use this case to answer the following questions: ? A 5-year-old boy visits his primary care physician after an accident on his bike.It was his first accident,and he fell on his knees.His mother noticed severe swelling in his knees and elbows but thought that it was from the accident.She placed an ice pack on the affected areas and put him to rest.After a few days,the swelling had not improved,so she made an appointment to see his physician who asks him a few questions about the accident and then proceeds to perform a physical examination.The physician notes small hematomas on his elbows,knees,and his upper torso.The results from the blood draw follow. PT: 12.2 sec (RR: 11.3-12.8 sec) INR: 1.12 APTT: 72 sec (RR: 23-32 sec) Platelet aggregation studies: normal aggregation with all agonists The physician admits him to the area hospital.What should be the next course of action in investigating these results?

Explain why disseminated intravascular coagulation is not a primary disease state.Correlate etiology,pathophysiology,and laboratory analysis in your response.