Question 1

Which of the following is not involved in "contact activation"?

Accepted Answer

A) Factor XII 
B) Factor XI 
C) PK 
D) Factor X 
A) Factor XII 
B) Factor XI 
C) PK 
D) Factor X D

Question 2

The prothrombin group includes of which of the following?

Accepted Answer

A) Factor V 
B) Factor VII 
C) Factor XII 
D) Factor VIII 
A) Factor V 
B) Factor VII 
C) Factor XII 
D) Factor VIII B

Question 3

Thrombin activatable fibrinolysis inhibitor (TAFI)is defined as a:

Accepted Answer

A) Procoagulant 
B) Anticoagulant 
C) Profibrinolytic 
D) Antifibrinolytic 
A) Procoagulant 
B) Anticoagulant 
C) Profibrinolytic 
D) Antifibrinolytic D

Question 4

Interpret the following results: -Patient: 12-year-old boy with unexplained bruising,swollen knee joints,and prolonged bleeding from injuries
-Screening tests:
-PT = 12.2 sec (control: 11.5-13.3 sec)/INR: 1.09
-APTT = 57 sec (control: 23-32 sec)
-Bleeding time = 5 min (control: 2-10 min)
Pending results from confirmation tests,this patient could be suffering from:

Accepted Answer

A) An intrinsic pathway problem 
B) An extrinsic pathway problem 
C) A primary hemostasis problem 
D) A common pathway problem 
A) An intrinsic pathway problem 
B) An extrinsic pathway problem 
C) A primary hemostasis problem 
D) A common pathway problem

Question 5

Which plasminogen activator (PA)is distinctive among the serine proteases because it does not circulate as a zymogen but is fully active toward its substrate plasminogen in a single-chain form?

Accepted Answer

A) uPA 
B) uPAR 
C) PLG 
D) tPA 
A) uPA 
B) uPAR 
C) PLG 
D) tPA

Question 6

Triggering the contact activation factors of the intrinsic pathway does not require which of the following components?

Accepted Answer

A) Vitamin K 
B) Calcium 
C) Serine protease 
D) Kinins 
A) Vitamin K 
B) Calcium 
C) Serine protease 
D) Kinins

Question 7

Which of the following is not formed on a phospholipid surface?

Accepted Answer

A) Extrinsic Xase 
B) Intrinsic Xase 
C) Prothrombinase 
D) Factor VIIa 
A) Extrinsic Xase 
B) Intrinsic Xase 
C) Prothrombinase 
D) Factor VIIa

Question 8

On which chromosome does the factor VIII locus reside?

Accepted Answer

A) 3 
B) 4 
C) 11 
D) X 
A) 3 
B) 4 
C) 11 
D) X

Question 9

Which of the following is responsible for urokinase-catalyzed plasminogen (PLG)activation?

Accepted Answer

A) ADAMTS-13 
B) LRP 
C) UPAR 
D) EPCR 
A) ADAMTS-13 
B) LRP 
C) UPAR 
D) EPCR

Question 10

All of the following are necessary for a clot to form except:

Accepted Answer

A) Platelets 
B) Coagulation protein 
C) Plasmin 
D) Endothelial cells 
A) Platelets 
B) Coagulation protein 
C) Plasmin 
D) Endothelial cells

Question 11

Which of the following is not a role of high molecular weight kininogen?

Accepted Answer

A) Accelerate the rate of surface-dependent activation of F-XII 
B) Serves as a nonenzymatic cofactor in contact factor activation 
C) Provide bradykinin 
D) Accelerates the formation of Factor VIIa 
A) Accelerate the rate of surface-dependent activation of F-XII 
B) Serves as a nonenzymatic cofactor in contact factor activation 
C) Provide bradykinin 
D) Accelerates the formation of Factor VIIa

Question 12

Platelet activation and subsequent formation of the platelet plug are involved in:

Accepted Answer

A) Primary hemostasis 
B) Secondary hemostasis 
C) Fibrinolysis 
D) Inhibitory system 
A) Primary hemostasis 
B) Secondary hemostasis 
C) Fibrinolysis 
D) Inhibitory system

Question 13

What are the roles of thrombin in coagulation?

Accepted Answer

•Platelet aggregation
•Factor activation

Question 14

Which of the following coagulation factors is(are)found in the extrinsic pathway?

Accepted Answer

A) HK and FXII 
B) FXI and FIX 
C) FVII and TF 
D) FX 
A) HK and FXII 
B) FXI and FIX 
C) FVII and TF 
D) FX

Question 15

Activation of circulating zymogens is achieved through:

Accepted Answer

A) Sympathetic nervous system stimulation 
B) Endomitosis 
C) Splenic sequestration 
D) Proteolytic cleavage 
A) Sympathetic nervous system stimulation 
B) Endomitosis 
C) Splenic sequestration 
D) Proteolytic cleavage

Question 16

Which of the following is the smallest degradation product of fibrin?

Accepted Answer

A) Fragment X 
B) Fragment Y 
C) D-dimer 
D) E fragment 
A) Fragment X 
B) Fragment Y 
C) D-dimer 
D) E fragment

Question 17

Why is vitamin K necessary for some coagulation proteins to become functional?

Accepted Answer

A) Vitamin K activates coagulation zymogens. 
B) Vitamin K binds coagulation factors to a phospholipid surface. 
C) Vitamin K combines with VWF in the circulation. 
D) Vitamin K is required for gamma-carboxylation of glutamic acid residues. 
A) Vitamin K activates coagulation zymogens. 
B) Vitamin K binds coagulation factors to a phospholipid surface. 
C) Vitamin K combines with VWF in the circulation. 
D) Vitamin K is required for gamma-carboxylation of glutamic acid residues.

Question 18

Which of the following degrades factors V and VIII?

Accepted Answer

A) TFPI 
B) SERPINs 
C) Proteins C and S 
D) APS 
A) TFPI 
B) SERPINs 
C) Proteins C and S 
D) APS

Question 19

The role of vitamin K in hemostasis is to:

Accepted Answer

A) Promote contact factor activation 
B) Facilitate calcium binding to essential factors 
C) Initiate extrinsic pathway activation 
D) Cross-link the fibrin monomers 
A) Promote contact factor activation 
B) Facilitate calcium binding to essential factors 
C) Initiate extrinsic pathway activation 
D) Cross-link the fibrin monomers

Question 20

What is the key component in secondary hemostasis that binds the platelets into a solid plug?

Accepted Answer

A) Fibrin 
B) Tissue factor 
C) Plasminogen 
D) Thrombin 
A) Fibrin 
B) Tissue factor 
C) Plasminogen 
D) Thrombin

Exam 32: Secondary Hemostasis and Fibrinolysis

Which of the following is not involved in "contact activation"?

The prothrombin group includes of which of the following?

Thrombin activatable fibrinolysis inhibitor (TAFI)is defined as a:

Which plasminogen activator (PA)is distinctive among the serine proteases because it does not circulate as a zymogen but is fully active toward its substrate plasminogen in a single-chain form?

Triggering the contact activation factors of the intrinsic pathway does not require which of the following components?

Which of the following is not formed on a phospholipid surface?

On which chromosome does the factor VIII locus reside?

Which of the following is responsible for urokinase-catalyzed plasminogen (PLG)activation?

All of the following are necessary for a clot to form except:

Which of the following is not a role of high molecular weight kininogen?

Platelet activation and subsequent formation of the platelet plug are involved in:

What are the roles of thrombin in coagulation?

Which of the following coagulation factors is(are)found in the extrinsic pathway?

Activation of circulating zymogens is achieved through:

Which of the following is the smallest degradation product of fibrin?

Why is vitamin K necessary for some coagulation proteins to become functional?

Which of the following degrades factors V and VIII?

The role of vitamin K in hemostasis is to:

What is the key component in secondary hemostasis that binds the platelets into a solid plug?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Filters