Question 1

How does systemic fibrinolysis differ from physiologic fibrinolysis?

Accepted Answer

A) Systemic produces rapid fibrinolysis,whereas physiologic produces adequate fibrinolysis. 
B) Systemic results from improper plasminogen activation,whereas physiologic results from proper plasminogen activation. 
C) Physiologic is naturally occurring,whereas systemic results from an external trigger. 
D) Physiologic is localized to the fibrin clot,whereas systemic results in circulating plasmin. 
A) Systemic produces rapid fibrinolysis,whereas physiologic produces adequate fibrinolysis. 
B) Systemic results from improper plasminogen activation,whereas physiologic results from proper plasminogen activation. 
C) Physiologic is naturally occurring,whereas systemic results from an external trigger. 
D) Physiologic is localized to the fibrin clot,whereas systemic results in circulating plasmin.

Question 2

Which of the following is a role of thrombin?

Accepted Answer

A) Activates anticoagulant (protein 
C)  
B) Increases fibrinolysis 
C) Inhibits endothelial cell release of tissue plasminogen activator 
D) Inhibits the formation of fibrin monomers 
A) Activates anticoagulant (protein 
C)  
B) Increases fibrinolysis 
C) Inhibits endothelial cell release of tissue plasminogen activator 
D) Inhibits the formation of fibrin monomers

Question 3

Which domain of the blood coagulation protein is responsible for its distinctive identity?

Accepted Answer

A) Signal peptide domain 
B) Catalytic domain 
C) Epidermal growth factor domain 
D) Noncatalytic domain 
A) Signal peptide domain 
B) Catalytic domain 
C) Epidermal growth factor domain 
D) Noncatalytic domain

Question 4

The substance directly responsible for the physical breakdown of the thrombus is:

Accepted Answer

A) Plasmin 
B) Plasminogen 
C) Tissue plasminogen activator 
D) Fibrin 
A) Plasmin 
B) Plasminogen 
C) Tissue plasminogen activator 
D) Fibrin

Question 5

During activation of coagulation,all of the following bind to the phospholipid membrane surface forming a complex except:

Accepted Answer

A) Procoagulant zymogen (substrate) 
B) Coagulation inhibitors 
C) Procoagulant cofactors 
D) Activated serine protease 
A) Procoagulant zymogen (substrate) 
B) Coagulation inhibitors 
C) Procoagulant cofactors 
D) Activated serine protease

Question 6

Which of the following is responsible for cleaving ultra-large VWF multimers into functional units?

Accepted Answer

A) LRP 
B) ADAMTS-13 
C) EPCR 
D) UPAR 
A) LRP 
B) ADAMTS-13 
C) EPCR 
D) UPAR

Question 7

How do the following systems contribute to coagulation?
a.Complement
b.Fibrinolysis
c.Kinin

Accepted Answer

Complement: Plasmin activates

Question 8

Which of the following is primarily responsible for neutralizing the extrinsic tenase complex?

Accepted Answer

A) TFPI 
B) SERPINs 
C) Proteins C and S 
D) APS 
A) TFPI 
B) SERPINs 
C) Proteins C and S 
D) APS

Question 9

What factor does the extrinsic pathway require that the intrinsic and common pathways do not?

Accepted Answer

A) Vitamin K 
B) Zymogens 
C) Tissue factor 
D) tPA 
A) Vitamin K 
B) Zymogens 
C) Tissue factor 
D) tPA

Question 10

What reflex test should be done on a patient with an abnormal APTT who is suspected of having hemophilia?

Accepted Answer

A) Platelet function assay 
B) Factor assay 
C) Quantitative fibrinogen assay 
D) Assay for D-dimer 
A) Platelet function assay 
B) Factor assay 
C) Quantitative fibrinogen assay 
D) Assay for D-dimer

Question 11

Thrombin activity impacts coagulation by which of the following mechanism(s)?

Accepted Answer

A) Altering blood flow 
B) Positive feedback only 
C) Negative feedback only 
D) Positive and negative feedback 
A) Altering blood flow 
B) Positive feedback only 
C) Negative feedback only 
D) Positive and negative feedback

Question 12

Hemostasis depends on which of the following?

Accepted Answer

A) The interaction between coagulation and fibrinolysis inhibitors 
B) The interaction between platelets,coagulation proteins,and blood vessels 
C) The rate of platelet destruction 
D) the rate of endothelial cell turnover 
A) The interaction between coagulation and fibrinolysis inhibitors 
B) The interaction between platelets,coagulation proteins,and blood vessels 
C) The rate of platelet destruction 
D) the rate of endothelial cell turnover

Question 13

Compare and contrast systemic and physiologic fibrinolysis.

Accepted Answer

Physiologic fibrinolysis: highly fibrin-

Exam 32: Secondary Hemostasis and Fibrinolysis

How does systemic fibrinolysis differ from physiologic fibrinolysis?

Which of the following is a role of thrombin?

Which domain of the blood coagulation protein is responsible for its distinctive identity?

The substance directly responsible for the physical breakdown of the thrombus is:

During activation of coagulation,all of the following bind to the phospholipid membrane surface forming a complex except:

Which of the following is responsible for cleaving ultra-large VWF multimers into functional units?

How do the following systems contribute to coagulation? a.Complement b.Fibrinolysis c.Kinin

Which of the following is primarily responsible for neutralizing the extrinsic tenase complex?

What factor does the extrinsic pathway require that the intrinsic and common pathways do not?

What reflex test should be done on a patient with an abnormal APTT who is suspected of having hemophilia?

Thrombin activity impacts coagulation by which of the following mechanism(s)?

Hemostasis depends on which of the following?

Compare and contrast systemic and physiologic fibrinolysis.

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Filters