Question 1

What test can demonstrate the presence of alloantibody?

Accepted Answer

A) Antibody screen 
B) Agglutination in saline 
C) Direct antiglobulin test 
D) Indirect antiglobulin test 
A) Antibody screen 
B) Agglutination in saline 
C) Direct antiglobulin test 
D) Indirect antiglobulin test

Question 2

A patient with SLE shows evidence of decreased hemoglobin and ongoing hemolysis.The DAT is negative.Which of the following is the most likely explanation for these results?

Accepted Answer

A) The subclass of IgG is not recognized by the polyspecific AHG. 
B) The thermal amplitude of the antibody is <37°C. 
C) High-dose IVIG used in treatment is interfering with the binding of AHG. 
D) There is insufficient IgG for detection. 
A) The subclass of IgG is not recognized by the polyspecific AHG. 
B) The thermal amplitude of the antibody is <37°C. 
C) High-dose IVIG used in treatment is interfering with the binding of AHG. 
D) There is insufficient IgG for detection.

Question 3

Which of the following set of results is consistent with a diagnosis of WAIHA?

Accepted Answer

The answer of Which of the following set of results...

Question 4

Paroxysmal cold hemoglobinuria is associated with viral and bacterial infections in children.With what other disease(s)is it associated?

Accepted Answer

A) Lymphoproliferative diseases in adults 
B) Mixed-type AIHA 
C) CAD 
D) Warm autoimmune hemolytic anemia 
A) Lymphoproliferative diseases in adults 
B) Mixed-type AIHA 
C) CAD 
D) Warm autoimmune hemolytic anemia

Question 5

Which of the following is an example of an anemia that occurs as a result of antibody development to an antigen that the individual lacks?

Accepted Answer

A) Autoimmune hemolytic anemia 
B) Mixed-type autoimmune hemolytic anemia 
C) Drug-induced hemolysis 
D) Hemolytic disease of the newborn 
A) Autoimmune hemolytic anemia 
B) Mixed-type autoimmune hemolytic anemia 
C) Drug-induced hemolysis 
D) Hemolytic disease of the newborn

Question 6

Which of the following is consistent with a diagnosis of CAD?

Accepted Answer

A) MCHC 44 g/dL 
B) DAT positive with polyspecific AHG and anti-IgG 
C) Spherocytes on the peripheral blood smear 
D) MCV 104 fL 
A) MCHC 44 g/dL 
B) DAT positive with polyspecific AHG and anti-IgG 
C) Spherocytes on the peripheral blood smear 
D) MCV 104 fL

Question 7

The absence of spherocytes on the peripheral blood smear in a case of suspected HDFN usually indicates that which of the following is the most likely cause of the condition?

Accepted Answer

A) ABO HDFN 
B) Splenic hypertrophy 
C) Rh HDFN 
D) HDFN from other blood group antibodies 
A) ABO HDFN 
B) Splenic hypertrophy 
C) Rh HDFN 
D) HDFN from other blood group antibodies

Question 8

Which of the following has the greatest effect on the rate of hemolysis in immune hemolytic anemia?

Accepted Answer

A) Presence of IgG₂ on the erythrocyte 
B) Limited number of antigens 
C) Antibody that reacts at 37° C 
D) Presence of IgM antibody 
A) Presence of IgG₂ on the erythrocyte 
B) Limited number of antigens 
C) Antibody that reacts at 37° C 
D) Presence of IgM antibody

Question 9

Which of the following pairs of mother and fetus shows the most likely potential for initiating HDFN in the fetus?
Mother Fetus

Accepted Answer

A) Group A,Rh positiveGroup O,Rh positive 
B) Group B,Rh negativeGroup O,Rh positive 
C) Group AB,Rh positiveGroup A,Rh negative 
D) Group A,Rh negativeGroup AB,Rh negative 
A) Group A,Rh positiveGroup O,Rh positive 
B) Group B,Rh negativeGroup O,Rh positive 
C) Group AB,Rh positiveGroup A,Rh negative 
D) Group A,Rh negativeGroup AB,Rh negative

Question 10

A Group O,Rh-negative woman with no evidence of antibodies delivers her first child who shows a slightly decreased hemoglobin and the presence of spherocytes on the peripheral blood film.The DAT is positive with polyspecific AHG and anti-IgG.The baby is Group A,Rh negative and is slightly jaundiced with a bilirubin of 2.1 mg/dl.What is the most likely cause of the baby's jaundice?

Accepted Answer

A) Normal physiologic jaundice 
B) Rh HDFN 
C) ABO HDFN 
D) Other type HDFN 
A) Normal physiologic jaundice 
B) Rh HDFN 
C) ABO HDFN 
D) Other type HDFN

Exam 19: Hemolytic Anemia: Immune Anemias

What test can demonstrate the presence of alloantibody?

A patient with SLE shows evidence of decreased hemoglobin and ongoing hemolysis.The DAT is negative.Which of the following is the most likely explanation for these results?

Which of the following set of results is consistent with a diagnosis of WAIHA?

Paroxysmal cold hemoglobinuria is associated with viral and bacterial infections in children.With what other disease(s)is it associated?

Which of the following is an example of an anemia that occurs as a result of antibody development to an antigen that the individual lacks?

Which of the following is consistent with a diagnosis of CAD?

The absence of spherocytes on the peripheral blood smear in a case of suspected HDFN usually indicates that which of the following is the most likely cause of the condition?

Which of the following has the greatest effect on the rate of hemolysis in immune hemolytic anemia?

Which of the following pairs of mother and fetus shows the most likely potential for initiating HDFN in the fetus? Mother Fetus

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Filters