Question 1

Which of the following characteristics differentiates Hodgkin and non-Hodgkin lymphomas?

Accepted Answer

A) Molecular diagnostics and flow cytometry test results 
B) Cytochemical and cytogenetic findings 
C) Stage,distribution,mode of spread,extranodal disease,peripheral blood,cell type,and treatment regimen 
D) Nodular growth pattern,BCL expression,and CD19+ 
A) Molecular diagnostics and flow cytometry test results 
B) Cytochemical and cytogenetic findings 
C) Stage,distribution,mode of spread,extranodal disease,peripheral blood,cell type,and treatment regimen 
D) Nodular growth pattern,BCL expression,and CD19+

Question 2

Which of the following best represents the hematologic picture of a patient with lymphoma?

Accepted Answer

A) Prominent lymphocytosis 
B) Normal until later stages of the disease 
C) Prominent leukocytosis 
D) Low hemoglobin,hematocrit,and platelet count 
A) Prominent lymphocytosis 
B) Normal until later stages of the disease 
C) Prominent leukocytosis 
D) Low hemoglobin,hematocrit,and platelet count

Question 3

An increase in paraprotein concentration of a single isoform is defined as:

Accepted Answer

A) Immune response 
B) Monoclonal gammopathy 
C) Oligoclonal banding 
D) Hyperparaproteinemia. 
A) Immune response 
B) Monoclonal gammopathy 
C) Oligoclonal banding 
D) Hyperparaproteinemia.

Question 4

Identify the lab features of the following disorders:
a.Plasmacytoma
b.Multiple myeloma
c.MGUS
d.Waldenström's macroglobulinemia

Accepted Answer

Plasmacytoma: Localized tumor collection

Question 5

A technologist is reviewing a lymph node biopsy slide and notices a prominent lymphocytosis as well as the presence of a few tumor cells with the following characteristics: large,multilobated nucleus with delicate nuclear membranes;finely granular chromatin;and small,indistinct nucleoli.Based on this information,from what stage and disease is the patient most likely suffering?

Accepted Answer

A) Anaplastic large cell lymphoma 
B) Lymphocyte predominant Hodgkin lymphoma 
C) Monoclonal gammopathy of undetermined significance 
D) Lymphocyte-depleted Hodgkin lymphoma 
A) Anaplastic large cell lymphoma 
B) Lymphocyte predominant Hodgkin lymphoma 
C) Monoclonal gammopathy of undetermined significance 
D) Lymphocyte-depleted Hodgkin lymphoma

Question 6

The presence of which of the following cells in peripheral circulation strongly indicates Sézary syndrome?

Accepted Answer

A) Lymphocytes with nuclear clefting 
B) Lymphocytes with cerebriform convoluted nuclei 
C) Normal lymphocytes 
D) Lymphocytes with bilobed nuclei 
A) Lymphocytes with nuclear clefting 
B) Lymphocytes with cerebriform convoluted nuclei 
C) Normal lymphocytes 
D) Lymphocytes with bilobed nuclei

Question 7

Which of the following test results is most consistent with a diagnosis of multiple myeloma?

Accepted Answer

A) Increased plasma cell concentration in peripheral circulation 
B) Low calcium levels 
C) RBC aggregates on the peripheral blood smear 
D) Blasts in the peripheral blood 
A) Increased plasma cell concentration in peripheral circulation 
B) Low calcium levels 
C) RBC aggregates on the peripheral blood smear 
D) Blasts in the peripheral blood

Question 8

A 15-year-old patient has an active infection with Epstein-Barr virus,which will lead to which of the following?

Accepted Answer

A) Leukemia 
B) Lymphoma 
C) Multiple myeloma 
D) Lymphadenopathy 
A) Leukemia 
B) Lymphoma 
C) Multiple myeloma 
D) Lymphadenopathy

Question 9

Which protein is identified as a free light chain in the urine?

Accepted Answer

A) MGUS 
B) Heavy chains 
C) M spike 
D) Bence-Jones 
A) MGUS 
B) Heavy chains 
C) M spike 
D) Bence-Jones

Question 10

Which of the following statements is correct regarding monoclonal gammopathy of undetermined significance (MGUS)and multiple myeloma (MM)?

Accepted Answer

A) MGUS has a low level of monoclonal spike without an underlying neoplasm,whereas MM has a monoclonal spike with an underlying neoplasm. 
B) MGUS has a monoclonal spike that is IgM in nature,whereas MM has a monoclonal spike that is IgG in nature. 
C) MGUS exhibits tumor localization,whereas MM exhibits tumor dissemination. 
D) MGUS and MM are the same. 
A) MGUS has a low level of monoclonal spike without an underlying neoplasm,whereas MM has a monoclonal spike with an underlying neoplasm. 
B) MGUS has a monoclonal spike that is IgM in nature,whereas MM has a monoclonal spike that is IgG in nature. 
C) MGUS exhibits tumor localization,whereas MM exhibits tumor dissemination. 
D) MGUS and MM are the same.

Question 11

Large cells with abundant,intensely basophilic cytoplasm with prominent cytoplasmic vacuolization are identified on a peripheral smear.Multiple basophilic nucleoli are present.A starry sky appearance is seen with fields of basophilic leukemic blasts with benign macrophages that have ingested tumor cells.What leukemia should be suspected with this morphology?

Accepted Answer

A) Acute undifferentiated leukemia 
B) Acute lymphoblastic leukemia-Burkitt-type 
C) Acute leukemia with lineage heterogeneity 
D) Precursor T-cell leukemia 
A) Acute undifferentiated leukemia 
B) Acute lymphoblastic leukemia-Burkitt-type 
C) Acute leukemia with lineage heterogeneity 
D) Precursor T-cell leukemia

Question 12

A patient's symptoms include visual impairment,headache,dizziness,and deafness.The peripheral blood smear reveals lymphoplasmacytic lymphoma.What would rule out the diagnosis of Waldenström's macroglobulinemia?

Accepted Answer

A) Elevated plasma levels of IgM 
B) Increased serum viscosity levels 
C) Decreased plasma levels of IgM 
D) Plasma cell neoplasm with lytic bone lesions 
A) Elevated plasma levels of IgM 
B) Increased serum viscosity levels 
C) Decreased plasma levels of IgM 
D) Plasma cell neoplasm with lytic bone lesions

Question 13

A bone marrow aspirate is performed for staging purposes on a patient with Hodgkin lymphoma.The results come back positive for infiltration by Reed Sternberg cells.This means that the patient is:

Accepted Answer

A) In the early stages of the disease. 
B) In the late stages of the disease. 
C) Converting to non-Hodgkin lymphoma. 
D) Entering remission. 
A) In the early stages of the disease. 
B) In the late stages of the disease. 
C) Converting to non-Hodgkin lymphoma. 
D) Entering remission.

Question 14

In multiple myeloma,the erythrocytes have a distinct abnormality in the peripheral blood.Which of the following is that abnormality?

Accepted Answer

A) Rouleaux formation 
B) Moth-eaten appearance 
C) Agglutinates 
D) Polychromasia 
A) Rouleaux formation 
B) Moth-eaten appearance 
C) Agglutinates 
D) Polychromasia

Question 15

Hairy cell leukemia and chronic lymphocytic leukemia appear morphologically similar to the untrained eye.Which of the following tests would help differentiate the two?

Accepted Answer

A) Immunophenotyping 
B) Cytogenetic analysis 
C) TRAP stain 
D) PAS staining 
A) Immunophenotyping 
B) Cytogenetic analysis 
C) TRAP stain 
D) PAS staining

Question 16

Which of the following laboratory tests would best help differentiate multiple myeloma and Waldenstrom's macroglobulinemia?

Accepted Answer

A) Peripheral blood smear 
B) Isoelectric focusing 
C) Bone marrow aspirate 
D) Total protein measurement 
A) Peripheral blood smear 
B) Isoelectric focusing 
C) Bone marrow aspirate 
D) Total protein measurement

Question 17

Which subgroup of CLL reveals pancytopenia,TRAP+,CD19+,CD5−,CD20+ strong intensity,CD22+,CD103+,CD11c+,and CD25+ with circulating hairy cells?

Accepted Answer

A) B-cell chronic lymphocytic leukemia 
B) T-cell PLL 
C) Hairy cell leukemia 
D) Sézary syndrome 
A) B-cell chronic lymphocytic leukemia 
B) T-cell PLL 
C) Hairy cell leukemia 
D) Sézary syndrome

Question 18

Explain the major differences between Hodgkin and non-Hodgkin lymphomas.

Accepted Answer

Hodgkin lymphoma:
-Stage: localized
-Dis

Question 19

List and describe the five stages of Hodgkin lymphoma,focusing on laboratory features.

Accepted Answer

•	Lymphocyte predominant (LP): 4+ lympho

Exam 28: Mature Lymphoid Neoplasms

Which of the following characteristics differentiates Hodgkin and non-Hodgkin lymphomas?

Which of the following best represents the hematologic picture of a patient with lymphoma?

An increase in paraprotein concentration of a single isoform is defined as:

Identify the lab features of the following disorders: a.Plasmacytoma b.Multiple myeloma c.MGUS d.Waldenström's macroglobulinemia

The presence of which of the following cells in peripheral circulation strongly indicates Sézary syndrome?

Which of the following test results is most consistent with a diagnosis of multiple myeloma?

A 15-year-old patient has an active infection with Epstein-Barr virus,which will lead to which of the following?

Which protein is identified as a free light chain in the urine?

Which of the following statements is correct regarding monoclonal gammopathy of undetermined significance (MGUS)and multiple myeloma (MM)?

A patient's symptoms include visual impairment,headache,dizziness,and deafness.The peripheral blood smear reveals lymphoplasmacytic lymphoma.What would rule out the diagnosis of Waldenström's macroglobulinemia?

A bone marrow aspirate is performed for staging purposes on a patient with Hodgkin lymphoma.The results come back positive for infiltration by Reed Sternberg cells.This means that the patient is:

In multiple myeloma,the erythrocytes have a distinct abnormality in the peripheral blood.Which of the following is that abnormality?

Hairy cell leukemia and chronic lymphocytic leukemia appear morphologically similar to the untrained eye.Which of the following tests would help differentiate the two?

Which of the following laboratory tests would best help differentiate multiple myeloma and Waldenstrom's macroglobulinemia?

Which subgroup of CLL reveals pancytopenia,TRAP+,CD19+,CD5−,CD20+ strong intensity,CD22+,CD103+,CD11c+,and CD25+ with circulating hairy cells?

Explain the major differences between Hodgkin and non-Hodgkin lymphomas.

List and describe the five stages of Hodgkin lymphoma,focusing on laboratory features.

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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