Exam 24: Myeloproliferative Neoplasms

Which of the following genes is associated with clonal hypereosinophilia?

What substance(s)is(are)primarily responsible for stimulating the growth and proliferation of fibroblasts in PMF?

The most striking finding in the peripheral blood in this disease is extreme and consistent thrombocytosis.Giant,bizarre platelet forms are present in the peripheral blood.Megakaryocytes and megakaryocyte fragments can be present.Abnormalities in platelet aggregation and adhesion are common.What is this disease?

The major cell line involved in the pathogenesis of PMF is which of the following?

Which myeloproliferative disorder typically produces a dramatic increase in all cell lines?

Which of the following tests would help differentiate ET from other causes of thrombocytosis?

The presence of which of the following in the bone marrow would lead a clinician to the diagnosis of a myeloproliferative disorder rather than an acute leukemia?

CML is typically diagnosed in which patient population?

What is the first step in identifying a variant of CML?

What laboratory finding distinguishes leukemoid reaction from CML?

Interpret the following results: WBC count: 102 × 10⁹/L Differential: 13% segmented neutrophils 28% band neutrophils 15% metamyelocytes 8% myelocytes 6% promyelocytes 15% lymphocytes 8% basophils 7% monocytes LAP score: 15 (reference interval: 0-400) What disease is associated with this WBC differential and LAP score?

What cell appears to be the primary site for the defect in MPN?

Explain the significance of the Philadelphia chromosome in ALL.

A routine CBC is ordered on a patient.Results are as follows: WBC count: 22.0 × 10⁹/L PLT: 957 × 10⁹/L RBC: 5.00 × 10¹²/L PB smear: moderate platelet clumping and giant platelets noted These results are characteristic of which disorder?

Which is found in >90% of cases of PV and promotes EPO receptor activation?

Contrast MDS and MPN utilizing laboratory test result information.

Which of the following is described by the presence of circulating mast cells in the peripheral blood (≥ 10%),mast cells composing > 20% of the nucleated cells in bone marrow,and multiorgan failure:

Which age range is nearest to the peak incidence of CML?

Which CBC findings would suggest an MPN?

Increased sensitivity to which cytokine(s)is thought to be partially responsible for the increased megakaryocyte proliferation of ET?