Exam 19: Hemolytic Anemia: Immune Anemias

ABO incompatibility is associated with which type of transfusion reaction?

Paroxysmal cold hemoglobinuria is confirmed by a positive:

Compare cold hemolytic anemias to WAIHA by immunoglobin class, optimal reactivity temperature, and mechanism of hemolysis:

Which of the following pairs of mother and fetus shows the most likely potential for initiating HDFN in the fetus? Mother Fetus

A patient's hemoglobin went from a value of 13.0 gm/dl after transfusion to 10.6 gm/dl 3 days after transfusion. What is the most likely type of transfusion reaction?

A newborn is left at a hospital emergency department. The baby appears lethargic and slightly jaundiced. Laboratory work on the baby shows a positive DAT with polyspecific AHG and anti-IgG. The hemoglobin is 7.3 gm/dl, and the peripheral blood smear shows marked polychromasia, macrocytosis, and an increased number of nucleated RBCs. The bilirubin is 4.4 mg/dl. What do you suspect is the underlying cause of these results?

Compare the differences in the activation of complement that can lead to intravascular hemolysis or extravascular hemolysis.

Which of the following conditions is not paired with the correct autoantibody?

A patient presents with anemia and spherocytes on the peripheral smear. How would you differentiate between hereditary spherocytosis (HS) and WAIHA?

Autoantibodies associated with CAD are directed against which antigen system?

A patient with systemic lupus erythematosus (SLE) shows evidence of decreased hemoglobin and ongoing hemolysis. The DAT is negative. Which of the following is the most likely explanation for these results?

Which of the following is an example of an anemia that occurs as a result of antibody development to an antigen that the individual lacks?

A Group O, Rh-negative woman with no evidence of antibodies delivers her first child who shows a slightly decreased hemoglobin and the presence of spherocytes on the peripheral blood film. The DAT is positive with polyspecific AHG and anti-IgG. The baby is Group A, Rh negative and is slightly jaundiced with a bilirubin of 2.1 mg/dl. What is the most likely cause of the baby's jaundice?

A patient on α-methyldopa could develop a type of drug-induced immune hemolysis that mimics what condition?

Which of the following characterizes acute hemolytic transfusion reaction?

A sample demonstrates a DAT profile that is positive with polyspecific AHG, negative with anti-IgG, and positive with anti-C3. If the Donath-Landsteiner test was also positive, what should the clinical laboratory professional do?

Mixed-type AIHA is typically characterized by autoantibodies of which classes?

Cold autoimmune hemolytic anemia is usually caused by the presence of an:

Which of the following set of results is consistent with a diagnosis of WAIHA? Polyspecific AHG Anti-IgG Anti-C3

A patient is admitted with chest pain and extreme shortness of breath. Patient history is unremarkable except for ingestion of oral cefoxitin for the past 4 days. A DAT profile is positive with polyspecific AHG, negative with anti-IgG, and positive with anti-C3. The hemoglobin is 8.0 gm/dl. Based on these results, what mechanism of drug-induced hemolysis is present?