Question 1

Name the type of immune response that the granulocytes and monocytes predominately participate in and explain their role in this response.

Accepted Answer

Innate Immune Response (IRR): This is the body's first response to pathogens. Pathogen-associated molecular patterns (PAMP) are recognized by a leukocyte's surface receptors for PAMP (pattern recognition receptors [PRR]). Once a pathogen has been recognized, neutrophils, monocytes, and macrophages can phagocytose and kill the organism. The innate IR is rapid but limited.

Question 2

Which cell line is the first line of defense against helminth infections?

Accepted Answer

A)  Neutrophil 
B)  Lymphocyte 
C)  Monocyte 
D)  Eosinophil 
A)  Neutrophil 
B)  Lymphocyte 
C)  Monocyte 
D)  Eosinophil D

Question 3

Which of the following peripheral blood pictures is likely to be seen if elevated levels of GM-CSF persist in the bone marrow?

Accepted Answer

A)  Monocytosis, neutropenia 
B)  Neutrophilia, eosinophilia 
C)  Monocytopenia, granulocytosis 
D)  Granulocytosis, monocytosis 
A)  Monocytosis, neutropenia 
B)  Neutrophilia, eosinophilia 
C)  Monocytopenia, granulocytosis 
D)  Granulocytosis, monocytosis D

Question 4

What characteristic that is present in promyelocytes morphologically differentiates a promyelocyte from a myeloblast?

Accepted Answer

A)  Primary granules 
B)  Secondary granules 
C)  Loss of nucleoli 
D)  Pink cytoplasm 
A)  Primary granules 
B)  Secondary granules 
C)  Loss of nucleoli 
D)  Pink cytoplasm

Question 5

Name the cells of the neutrophil lineage in order from earliest morphologically recognizable cell to most mature cell and include one unique morphologic characteristic of each cell.

Accepted Answer

Myeloblast, promyelocyte, myelocyte, met

Question 6

Differentiate between absolute and relative concentrations of specific types of leukocytes and give an example of a condition that typically produces abnormal absolute or relative concentrations.

Accepted Answer

The relative concentration is the percen

Question 7

Hematological analysis was performed on a 10-day-old baby who appeared to have difficulty breathing and had a temperature of 101.2°F. The WBC was 29.8 × 109/L. This finding represents a(n):

Accepted Answer

A)  Normal leukocyte count 
B)  Absolute leukocytosis 
C)  Relative leukopenia 
D)  Absolute leukopenia 
A)  Normal leukocyte count 
B)  Absolute leukocytosis 
C)  Relative leukopenia 
D)  Absolute leukopenia

Question 8

List and explain the steps that neutrophils take to leave the peripheral blood circulation and lead to the neutrophil kill function.

Accepted Answer

Step 1: Antigen causes the release of ch

Question 9

An instrument printout shows a normal WBC count with a neutrophil count of 30%. What can be concluded from this?

Accepted Answer

A)  The patient is suffering from an infection. 
B)  There is a normal neutrophil concentration. 
C)  The patient has a relative neutropenia. 
D)  The patient is an infant. 
A)  The patient is suffering from an infection. 
B)  There is a normal neutrophil concentration. 
C)  The patient has a relative neutropenia. 
D)  The patient is an infant.

Question 10

IL-5 is the cytokine that is required for which cell type to proliferate and terminally differentiate?

Accepted Answer

A)  Neutrophil 
B)  Eosinophil 
C)  Basophil 
D)  Monocyte 
A)  Neutrophil 
B)  Eosinophil 
C)  Basophil 
D)  Monocyte

Question 11

Which cell line does not have a large reserve pool in the marrow?

Accepted Answer

A)  Granulocytic 
B)  Eosinophilic 
C)  Monocytic 
D)  Lymphocytic 
A)  Granulocytic 
B)  Eosinophilic 
C)  Monocytic 
D)  Lymphocytic

Question 12

All of the following can cause a leukocytosis except:

Accepted Answer

A)  Malignancy 
B)  Viral infection 
C)  Exposure to radiation 
D)  Immune responses 
A)  Malignancy 
B)  Viral infection 
C)  Exposure to radiation 
D)  Immune responses

Question 13

The basophil is the least plentiful cell found in the peripheral blood. What can it indicate when it is increased in the blood?

Accepted Answer

A)  Infection 
B)  Malignancy 
C)  Inflammation 
D)  Allergic reaction 
A)  Infection 
B)  Malignancy 
C)  Inflammation 
D)  Allergic reaction

Question 14

Which of the following terms is used to describe an absolute increase in the number of eosinophils?

Accepted Answer

A)  Neutropenia 
B)  Eosinophilia 
C)  Leukocytosis 
D)  Lymphocytosis 
A)  Neutropenia 
B)  Eosinophilia 
C)  Leukocytosis 
D)  Lymphocytosis

Question 15

All of the following are included in the kill mechanism by neutrophils except:

Accepted Answer

A)  Chemoattraction of neutrophils to infectious agent 
B)  Diapedesis of neutrophils from blood into tissues 
C)  The formation of the phagolysosome by the neutrophil 
D)  The presentation of the infectious agent to a monocyte for phagocytosis 
A)  Chemoattraction of neutrophils to infectious agent 
B)  Diapedesis of neutrophils from blood into tissues 
C)  The formation of the phagolysosome by the neutrophil 
D)  The presentation of the infectious agent to a monocyte for phagocytosis

Question 16

Routine hematological analysis was performed on a 21-year-old adult. The WBC was 8.3 × 109/L. This finding represents a(n):

Accepted Answer

A)  Normal leukocyte count 
B)  Absolute leukocytosis 
C)  Relative leukopenia 
D)  Absolute leukopenia 
A)  Normal leukocyte count 
B)  Absolute leukocytosis 
C)  Relative leukopenia 
D)  Absolute leukopenia

Question 17

A(n) ________ has purple-black granules that obscure the cytoplasm, whereas a(n) ________ contains granules that orange to red in color.

Accepted Answer

A)  eosinophil; neutrophil 
B)  monocyte; lymphocyte 
C)  lymphocyte; basophil 
D)  basophil; eosinophil 
A)  eosinophil; neutrophil 
B)  monocyte; lymphocyte 
C)  lymphocyte; basophil 
D)  basophil; eosinophil

Question 18

The process by which neutrophils migrate through the VEC into the tissues is known as:

Accepted Answer

A)  Chemotaxis 
B)  Opsonization 
C)  Diapedesis 
D)  Phagocytosis 
A)  Chemotaxis 
B)  Opsonization 
C)  Diapedesis 
D)  Phagocytosis

Question 19

List 4 locations of neutrophils and the three sub-locations within the bone marrow. Explain the general purpose of these locations.

Accepted Answer

(1) Bone marrow with (s) mitotic pool, (

Question 20

What cell lineage is characterized by the presence of CD14 on its surface?

Accepted Answer

A)  Neutrophilic 
B)  Eosinophilic 
C)  Monocytic 
D)  Lymphocytic 
A)  Neutrophilic 
B)  Eosinophilic 
C)  Monocytic 
D)  Lymphocytic

Exam 7: Granulocytes and Monocytes

Name the type of immune response that the granulocytes and monocytes predominately participate in and explain their role in this response.

Which cell line is the first line of defense against helminth infections?

Which of the following peripheral blood pictures is likely to be seen if elevated levels of GM-CSF persist in the bone marrow?

What characteristic that is present in promyelocytes morphologically differentiates a promyelocyte from a myeloblast?

Name the cells of the neutrophil lineage in order from earliest morphologically recognizable cell to most mature cell and include one unique morphologic characteristic of each cell.

Differentiate between absolute and relative concentrations of specific types of leukocytes and give an example of a condition that typically produces abnormal absolute or relative concentrations.

Hematological analysis was performed on a 10-day-old baby who appeared to have difficulty breathing and had a temperature of 101.2°F. The WBC was 29.8 × 109/L. This finding represents a(n):

List and explain the steps that neutrophils take to leave the peripheral blood circulation and lead to the neutrophil kill function.

An instrument printout shows a normal WBC count with a neutrophil count of 30%. What can be concluded from this?

IL-5 is the cytokine that is required for which cell type to proliferate and terminally differentiate?

Which cell line does not have a large reserve pool in the marrow?

All of the following can cause a leukocytosis except:

The basophil is the least plentiful cell found in the peripheral blood. What can it indicate when it is increased in the blood?

Which of the following terms is used to describe an absolute increase in the number of eosinophils?

All of the following are included in the kill mechanism by neutrophils except:

Routine hematological analysis was performed on a 21-year-old adult. The WBC was 8.3 × 109/L. This finding represents a(n):

A(n) ________ has purple-black granules that obscure the cytoplasm, whereas a(n) ________ contains granules that orange to red in color.

The process by which neutrophils migrate through the VEC into the tissues is known as:

List 4 locations of neutrophils and the three sub-locations within the bone marrow. Explain the general purpose of these locations.

What cell lineage is characterized by the presence of CD14 on its surface?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

Filters

Hematological analysis was performed on a 10-day-old baby who appeared to have difficulty breathing and had a temperature of 101.2°F. The WBC was 29.8 × 10⁹/L. This finding represents a(n):

Routine hematological analysis was performed on a 21-year-old adult. The WBC was 8.3 × 10⁹/L. This finding represents a(n):

A(n) has purple-black granules that obscure the cytoplasm, whereas a(n) contains granules that orange to red in color.