Exam 26: Acute Myeloid Leukemias

All of the following AML subtypes have positive reactivity with myeloperoxidase stain except:

According to the WHO classification, when differentiating myelodysplastic syndromes and acute leukemia, acute leukemia's:

A patient presents with 25% blasts (nonerythroid), 34% monocytic cells, and 31% granulocytic cells in the bone marrow. The peripheral blood smear has 10% monocytes. The alpha-naphthyl esterase and chloroacete esterase are positive. What is the probable diagnosis based on these findings?

Which of the following markers are positive for monoblasts?

The WHO classification system of AML incorporates which of the following?

A laboratory professional is reviewing a peripheral blood smear of a 10-year-old patient and notes that 35% blasts are present. Which of the following diagnoses is likely based on these findings?

A patient presents with bleeding and is found to be in DIC. The peripheral smear contains hypergranular promyelocytes. The white count is slightly elevated. The bone marrow contains cells with multiple Auer rods with a clear blue cytoplasm. What is the probable type of AML?

What is the most likely diagnosis?

Traditional therapy in APL includes pharmacological concentration of retinoic acid (ATRA) and chemotherapy. What is the function of the chemotherapy component in this treatment protocol?

How is erythrocyte morphology likely to be described in patients with AML?

What is the most likely diagnosis?

Which of the following confirms that a blast of unknown lineage is myeloid?

Which of the following does not fall into the category of AML as defined by the WHO classification?

A patient presents with acute leukemia with blasts identified by a positive CD34, CD13, and CD33. Less than 3% of the blasts stain positive for MPO and SBB. Which category of AML is the most likely diagnosis for this patient?

Predict the results of the immunophenotyping panel based on the information already given.

A PAS stain is ordered on a leukemic patient. The test is performed, and the technologist confirms that the PAS stain is positive with coarse granularity. Based on these findings, from what is the patient most likely suffering?

A major complication of APL is DIC, explain why that occurs.

The M:E ratio of a patient with AML typically displays which of the following?

List the common cytochemical stains used in the detection of AML and predict their results in AML.

What is the definition of acute leukemia, according to the World Health Organization?