Exam 21: Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

A patient presents with larger-than-normal neutrophils with hypersegmentation, oval macrocytes, and pancytopenia. This could be an indicator of:

A disorder characterized by a defect in glucocerebrosidase that results in a macrophage with cytoplasm appearing wrinkled or striated is:

Acute infection, inflammatory reaction, and administration of glucocorticosteroids can result in:

A patient has a high fever, leukopenia, thrombocytopenia, and elevated liver enzymes. A blood smear shows WBCs with large basophilic, spherical cellular inclusions. Which of the following is a likely cause for these findings?

Which of the following characteristics is associated with the neutrophilia that accompanies bacterial infection?

A patient presents with neutrophilia of 40 10⁹/L with many circulating immature cells. The blood contains many bands, metamyelocytes, myelocytes, promyelocytes, and a rare blast. No nucleated erythrocytes are present. What disease state is most likely with these results?

Name a type of condition that might cause the following alterations in morphology. a. Toxic granulation b. Vacuolization c. Morulae d. Eosinophilia

Interpret the following results: WBC count, 1.4 × 10⁹/L; bone marrow shows myeloid hypoplasia with a decreased M:E ratio of 1:1. There is no history of medications or drug exposure. What can be concluded from this?

Which of the following is associated with bacterial infections?

List three laboratory results that can distinguish a leukemoid reaction from CML.

A patient has an elevated WBC count with many circulating leukocyte precursors and a normal RBC count. Which of the following assays provides information that can best be used to diagnose this patient?

What causes sea-blue histiocytosis, and how is the sea-blue histiocyte identified?

A patient presents with a leukocyte count of 120 × 10⁹/L and splenomegaly. The blood smear reveals a shift to the left with promyelocytes and blasts. The platelets are increased, and the LAP is decreased. Which condition is associated with these results?

A peripheral blood smear examination shows many WBCs with many blue-staining round inclusions. Thrombocytopenia with giant platelets is present. What autosomal dominant disease is associated with these findings?

A laboratician is scanning a blood smear and notices that many of the neutrophils have more than six lobes. Which of the following would be consistent with that finding?

An adult patient's blood sample was collected in an EDTA blood collection tube for a CBC. The automated WBC count was 2.1 × 10⁹/L. Upon microscopic examination of the cells, the laboratory professional noted that the neutrophils adhered to the erythrocytes. What corrective action should be taken in this situation?

Which of the following is most likely able to distinguish a leukemoid reaction from CML?

Define leukoerythroblastosis, and name a condition in which this is seen.

A 45-year-old male visited his physician for a routine checkup. His absolute neutrophil count was 8.5 × 10⁹/L. Which of the following terms describes these results?

A 45-year-old female who returned from a trip abroad had nausea and diarrhea, and then later, muscle aches, fever, and chills. She was admitted to a local hospital and was diagnosed with the parasitic disease, trichinosis. Which of the following is most consistent with this disease?